GDH2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GDH2_SCHPO
• UniProt AC: Q9USN5
• Protein Name: Probable NAD-specific glutamate dehydrogenase
• Gene Name: gdh2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1106
• Subcellular Localization: Cytoplasm .
• Protein Description: NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate..
• Protein Sequence: MYLTKQIPHYSRIHTTQLLTVVNHRTIPFKIRGSFSNCRRYSNFATVPLLERPFKNKSKHNTARASRPFSTQKMLLTKSHPPNMYKDSVFFGYRPIVFSGKQDQKSKVIQCLRTERKTIPDDLVEDEVDRFYNKLGLDDYYFQMEPVSIIADHIEIIYAAKIAAHASHAKEELNIHVKNENEDLAIYLDSSPVTQPELDQSSAVEESISTRYLDPFKLTDPTAYRVESFTSVTNIDRTSTENSNIYTYFVTKCDFVDNPKKDASPDVPTDIASVSDKTFLEKASDNTIEMYQDVMNSVLTRFGPVVRLFDYQGRSEIRLVVGYRRGSIFQYFPSLSKLFRYYGLHSTRTYVEQFSNGVTIISYNFKPELFKNAAVTSINELFSQITREASLLYCLPSTDFQPLFVSEKLSIQEVTYAHCVRIFCEHVMNKLGPEYSSLSAILDHSNNIHAEILETIKRRLSTLAFTRTKIHDTIMQYPGLVHTLFEQFYLEHAINHNSTPHLHRAKSATSLADEASTYSITPMSATALMDLIQKTCTNEEDVSVMEMFVKFNTHLLKTNFFQTTKVALSFRFDPSFLDSTQYKDPLYAMIMSIGNEFRGFHLRFRDVARGGIRLIKSANPEAFGLNARGLFDENYNLAKTQMLKNKDIPEGGAKGVILLGKDCQDKPELAFMKYIDSIIDLLIVNKSQPLVDKLGKPEILFMGPDENTADLVNWATIHAHRRNAPWWKSFFTGKKPTMGGIPHDKYGMTSLSVRCYVEGIYKKLNITDPSKLTKVQTGGPDGDLGSNEIKLSNEKYIAVIDGSGVLYDPAGLDRTELLRLADERKTIDHFDAGKLSPEGYRVLVKDTNLKLPNGEIVRNGTIFRNTAHLRYKADTFVPCGGRPNAININNVEQLIDDHGRPAFKYLVEGANLFITQDAKSVLEKAGVIVIRDASANKGGVTSSSLEVLASLSFDDASFKENMCVHDGKVPTFYADYVNEVKRIIQRNANLEFEAIWKGHSENKIPYTSLSNHLSTEIVKLDHDIYNYEKLWADVGFRNAVLRASIPKTLQAKIGLEKMLERIPESYLRAIFSTYLASRFVYQHVVSSDPFAFFDYISTEMKMLKDA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
461	Phosphorylation	ETIKRRLSTLAFTRT HHHHHHHHHHHHCCC		25720772
507	Phosphorylation	PHLHRAKSATSLADE CCHHHCCCCCCCCHH		29996109
509	Phosphorylation	LHRAKSATSLADEAS HHHCCCCCCCCHHHC		25720772
510	Phosphorylation	HRAKSATSLADEAST HHCCCCCCCCHHHCC		29996109
516	Phosphorylation	TSLADEASTYSITPM CCCCHHHCCCCCCCC		29996109
518	Phosphorylation	LADEASTYSITPMSA CCHHHCCCCCCCCCH		27738172

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GDH2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GDH2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GDH2_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of GDH2_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.