dbPTM

GDE1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GDE1_SCHPO
UniProt AC	Q9C104
Protein Name	Glycerophosphodiester phosphodiesterase gde1
Gene Name	gde1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1076
Subcellular Localization	Cytoplasm .
Protein Description	Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline..
Protein Sequence	MLENDLQKVVNLFNTRIVQLDNYVTRLSTEKSPNTEITQALSSSYEAEEKAKQLKELDFRLQQLSSFCEWNKLAFEKLAANMDKHLGTERLVTFYEQKVCKLDFANSSKIYESMIALKALNSSQNDSEVKDKLEKLSIHHPLKKDLLAFIQLDIAAEVVTACINAPDSVLVDILAASIIAGAKACMREVIGRIGLRSECLASALRRAINNLCGPDEGVLYFLEVLKQICSVVYVDSYHSNRLLSRILLVERNSKGQSVMHSVAKLGWAGLCSKFCEIVSSIPDSEPLNWMLPCWRDVMHDTPLTLAIKGNHVEALHALLSAQDKETTSTKPGPVPPLVLTCCVGDYDLIVEELILAGFNPNEVDASSNTALHTAVRYNRPECVKMLLKLGANPSARDFLNSWTPLMLASATGLSEIVSILVASGASVDEVDSSGWTAMEQAVVRGYLHLADKLRTQVALSDKPVNLHTLYIKASSSEMRSRKRAMDLQLSRSVVIIRISDLAGRIRVSLQGDDAVYVSGRSPSFAASRPSSVDFMSQSTDSLSKNDTTASNGSMTPSSSQNNSVIIDIPRSHFDNAGEVCLENLAEPDEIADDSIHLHYDAAQENSPQPVNGSSPPYELVFVTRNTEEATITIDLLANRSHKILGRTVCCLTSLVSDLGNHMQSLKPLAPLPLLSSKTLKPIAHVNADVLISKVTVDDRFSSNDGISTPALSLEAVSNVSRTALEDAERSLHKSATTTSESGKSNGVAVIGHRGLGKNQPDRLSLQLGENTLQSFIKAADLGASYVELDVQMTKDMVPVVYHDFIVNETGTDAQVHSLTLEQFLGASHSPSEEIKDDASDIQQKRRPRAYSSSFTPSGSQVNFGEFAEENARLKPKVYKGNALGHTICAPFTTLKDVLKEVPQSVGLNVEFKYPMLSEAEEEKLLPIAYDYNFYVDTILSIIKKYGGKRKYIFSSFNPDICILLSLKSTNPVLFLTEGGTAYRTDVRAASLRQALKFASQWSFLGIVSACEPLIMCPRLIKAVKQLGLSCYTYGVLNNDVDNVRRQVRFGVDAVIVDNVLAIRRALNQYDESLESD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
521	Phosphorylation	AVYVSGRSPSFAASR EEEEECCCCCHHCCC	28.55	28889911
523	Phosphorylation	YVSGRSPSFAASRPS EEECCCCCHHCCCCC	28.85	28889911
527	Phosphorylation	RSPSFAASRPSSVDF CCCCHHCCCCCCCCC	41.09	25720772
530	Phosphorylation	SFAASRPSSVDFMSQ CHHCCCCCCCCCHHC	41.71	25720772
531	Phosphorylation	FAASRPSSVDFMSQS HHCCCCCCCCCHHCC	28.52	29996109
536	Phosphorylation	PSSVDFMSQSTDSLS CCCCCCHHCCCCCCC	22.44	29996109
548	Phosphorylation	SLSKNDTTASNGSMT CCCCCCCCCCCCCCC	30.83	28889911
553	Phosphorylation	DTTASNGSMTPSSSQ CCCCCCCCCCCCCCC	24.59	25720772
555	Phosphorylation	TASNGSMTPSSSQNN CCCCCCCCCCCCCCC	23.01	25720772
557	Phosphorylation	SNGSMTPSSSQNNSV CCCCCCCCCCCCCEE	33.19	29996109
701	Phosphorylation	VTVDDRFSSNDGIST CEECCCCCCCCCCCC	29.17	29996109
702	Phosphorylation	TVDDRFSSNDGISTP EECCCCCCCCCCCCC	35.91	29996109
707	Phosphorylation	FSSNDGISTPALSLE CCCCCCCCCCCCCHH	33.59	29996109
708	Phosphorylation	SSNDGISTPALSLEA CCCCCCCCCCCCHHH	15.62	29996109
738	Phosphorylation	LHKSATTTSESGKSN HHHCCCCCCCCCCCC	26.58	25720772
739	Phosphorylation	HKSATTTSESGKSNG HHCCCCCCCCCCCCC	27.89	25720772
850	Phosphorylation	QKRRPRAYSSSFTPS HHHCCCCCCCCCCCC	15.46	25720772
851	Phosphorylation	KRRPRAYSSSFTPSG HHCCCCCCCCCCCCC	20.65	28889911
852	Phosphorylation	RRPRAYSSSFTPSGS HCCCCCCCCCCCCCC	19.45	28889911
853	Phosphorylation	RPRAYSSSFTPSGSQ CCCCCCCCCCCCCCC	27.48	28889911
855	Phosphorylation	RAYSSSFTPSGSQVN CCCCCCCCCCCCCCC	20.63	25720772
857	Phosphorylation	YSSSFTPSGSQVNFG CCCCCCCCCCCCCHH	48.28	29996109
859	Phosphorylation	SSFTPSGSQVNFGEF CCCCCCCCCCCHHHH	34.98	25720772
1075	Phosphorylation	QYDESLESD------ HHHHHHHCC------	54.64	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GDE1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GDE1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GDE1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GDE1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GDE1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521; SER-523; SER-851;SER-852 AND SER-853, AND MASS SPECTROMETRY.	18257517 [Abstract]