GCR_CAVPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCR_CAVPO
• UniProt AC: P49115
• Protein Name: Glucocorticoid receptor
• Gene Name: NR3C1
• Organism: Cavia porcellus (Guinea pig).
• Sequence Length: 771
• Subcellular Localization: Cytoplasm . Nucleus . Mitochondrion . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . After ligand activation, translocates from the cytoplasm to the nucleus.
• Protein Description: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression..
• Protein Sequence: MDLKESVTSSKEVPSSVLGSERRNVIDFYKTVRGGATVKVSASSPSLAAAAQSDSKQRRLLVDFPKGSGSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLPSGETDFRLLEESIANLSRSTSVPENPKNSASAVSGTPTEEFPKTQSDLSSEQENLKSQAGTNGGNVKFPPDQSTFDILKDLEFSSGSPGKERSESPWRPDLLMDESCLLSPLAGEDDPFLLEGNSNEDCKPLILPDTKPKIKDNGDGILSSSNSVPQPQVKIGKEDFIELCTPGVIKQEKLGPVYCQASFSGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGEDNLTSLGTVNFPGRSVFSNGYSSPGLRPDVSSPPSSSSTTTGPPPKLCLVCSDELSGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRENCPACRYRKCLQAGMNLQARKTKKKIKGIQQATTGVSQNTSENPNKTIVPATLPQLTPTLVSLLEVIEPEVIHSGYDSTSPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFKNLHLDDQMTLLQYSWMFLMAFALGWRSYKQSNGSLLCFAPDLIINEQRMSLPWMYDQCRYMLYVSSELKRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSLHEIVGNLLNICFKTFLDKTMNIEFPEMLAEIITNQLPKYSNGDIKKLLFHQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MDLKESVTSSKEVPS CCHHHHCCCCCCCCH	36.24	-
22	Methylation	SSVLGSERRNVIDFY HHHCCCCCCCCHHHH	36.85	-
44	Phosphorylation	TVKVSASSPSLAAAA EEEEECCCHHHHHHH	20.44	-
133	Phosphorylation	ANLSRSTSVPENPKN HHHHCCCCCCCCCCC	36.60	-
199	Phosphorylation	DLEFSSGSPGKERSE HCCCCCCCCCCCCCC	32.21	-
207	Phosphorylation	PGKERSESPWRPDLL CCCCCCCCCCCCCCC	30.89	-
222	Phosphorylation	MDESCLLSPLAGEDD CCCHHCCCCCCCCCC	12.62	-
263	Phosphorylation	NGDGILSSSNSVPQP CCCCCCCCCCCCCCC	30.05	-
303	Phosphorylation	VYCQASFSGANIIGN EEEEEECCCCEECCC	34.20	-
400	Phosphorylation	GLRPDVSSPPSSSST CCCCCCCCCCCCCCC	40.45	-
475	Acetylation	CPACRYRKCLQAGMN CCHHHHHHHHHHCCC	30.29	-
487	Acetylation	GMNLQARKTKKKIKG CCCHHHHHHHHHHCH	68.65	-
489	Acetylation	NLQARKTKKKIKGIQ CHHHHHHHHHHCHHH	55.92	-
490	Acetylation	LQARKTKKKIKGIQQ HHHHHHHHHHCHHHH	66.03	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCR_CAVPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCR_CAVPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCR_CAVPO !!

Protein-Protein Interaction

Oops, there are no PPI records of GCR_CAVPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.