dbPTM

GCH1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GCH1_MOUSE
UniProt AC	Q05915
Protein Name	GTP cyclohydrolase 1
Gene Name	Gch1
Organism	Mus musculus (Mouse).
Sequence Length	241
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence..
Protein Sequence	MEKPRGVRCTNGFSERELPRPGASPPAEKSRPPEAKGAQPADAWKAGRHRSEEENQVNLPKLAAAYSSILLSLGEDPQRQGLLKTPWRAATAMQYFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	ELPRPGASPPAEKSR CCCCCCCCCCHHHCC	37.01	22942356
36	Ubiquitination	KSRPPEAKGAQPADA HCCCCCCCCCCCHHH	53.79	22790023
45	Ubiquitination	AQPADAWKAGRHRSE CCCHHHHHCCCCCCH	42.56	22790023
51	Phosphorylation	WKAGRHRSEEENQVN HHCCCCCCHHHHCCC	43.14	25521595
72	Phosphorylation	AYSSILLSLGEDPQR HHHHHHHHCCCCHHH	30.77	22817900
84	Ubiquitination	PQRQGLLKTPWRAAT HHHCCCCCCHHHHHH	58.55	22790023
151	Ubiquitination	HIGYLPNKQVLGLSK EEEECCCCHHHCHHH	39.58	22790023
157	Phosphorylation	NKQVLGLSKLARIVE CCHHHCHHHHHHHHH	24.67	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GCH1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GCH1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GCH1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
UBC_MOUSE	Ubc	physical	22984419

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GCH1_MOUSE

Related Literatures of Post-Translational Modification