GCDH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCDH_MOUSE
• UniProt AC: Q60759
• Protein Name: Glutaryl-CoA dehydrogenase, mitochondrial
• Gene Name: Gcdh
• Organism: Mus musculus (Mouse).
• Sequence Length: 438
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor..
• Protein Sequence: MSLRGVSARLLSRRSGLRFPRFPRTWSSAAAHTEKTQIRPAKSSRPVFDWKDPLILEEQLTADEKLIRDTFRNYCQERLMSRILLANRNEVFHRDIVYEMGELGVLGPTIKGYGCAGVSSVAYGLLTRELERVDSGYRSMMSVQSSLVMHPIYTYGSEEQRQKYLPGLAKGELLGCFGLTEPNHGSDPGGMETRARHNPSNQSYTLSGTKTWITNSPVADLFIVWARCEDNCIRGFILEKGMRGLSAPRIEGKFSLRASATGMIIMDSVEVPEENVLPNVSSLAGPFGCLNTARYGITWGVLGAAEFCLHTARQYALDRIQFGVPLARNQLVQKKLADMLTEITLGLHACLQLGRLKDQDKATPEMVSMLKRNNCGKALDIARQARDILGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTVGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Acetylation	SAAAHTEKTQIRPAK CCCCCCCCCCCCCCC	47.05	23576753
43	Phosphorylation	TQIRPAKSSRPVFDW CCCCCCCCCCCCCCC	33.41	23140645
44	Phosphorylation	QIRPAKSSRPVFDWK CCCCCCCCCCCCCCC	39.64	23140645
51	Acetylation	SRPVFDWKDPLILEE CCCCCCCCCCCHHHH	51.84	23576753
51	Succinylation	SRPVFDWKDPLILEE CCCCCCCCCCCHHHH	51.84	23806337
51	Succinylation	SRPVFDWKDPLILEE CCCCCCCCCCCHHHH	51.84	-
65	Acetylation	EQLTADEKLIRDTFR HHCCCCHHHHHHHHH	50.16	23576753
115	S-palmitoylation	PTIKGYGCAGVSSVA CCCCCCCCCCHHHHH	1.93	28526873
163	Acetylation	GSEEQRQKYLPGLAK CCHHHHHHHCCCCCC	51.44	23576753
170	Acetylation	KYLPGLAKGELLGCF HHCCCCCCCCEEEEE	58.94	23864654
176	S-nitrosocysteine	AKGELLGCFGLTEPN CCCCEEEEEECCCCC	2.17	-
176	S-nitrosylation	AKGELLGCFGLTEPN CCCCEEEEEECCCCC	2.17	21278135
176	S-palmitoylation	AKGELLGCFGLTEPN CCCCEEEEEECCCCC	2.17	28526873
200	Phosphorylation	TRARHNPSNQSYTLS CCCCCCCCCCCEEEE	53.47	29472430
240	Acetylation	IRGFILEKGMRGLSA EEHHHHHCCCCCCCC	55.34	23576753
240	Succinylation	IRGFILEKGMRGLSA EEHHHHHCCCCCCCC	55.34	23806337
253	Acetylation	SAPRIEGKFSLRASA CCCCEECCEEECCCC	20.99	23576753
289	S-palmitoylation	SLAGPFGCLNTARYG HHCCCCCHHHHHHHC	2.44	28526873
334	Acetylation	ARNQLVQKKLADMLT HHHHHHHHHHHHHHH	42.13	23864654
357	Acetylation	CLQLGRLKDQDKATP HHHHCCCCCCCCCCH	52.57	23864654
361	Acetylation	GRLKDQDKATPEMVS CCCCCCCCCCHHHHH	48.83	23864654
371	Succinylation	PEMVSMLKRNNCGKA HHHHHHHHHCCHHHH	44.42	23954790
371	Acetylation	PEMVSMLKRNNCGKA HHHHHHHHHCCHHHH	44.42	23864654
438	Succinylation	IQAFTVGK------- EEEEECCC-------	53.48	24315375
438	Acetylation	IQAFTVGK------- EEEEECCC-------	53.48	23864654

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCDH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCDH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCDH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GCDH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.