GBRL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRL2_MOUSE
• UniProt AC: P60521
• Protein Name: Gamma-aminobutyric acid receptor-associated protein-like 2
• Gene Name: Gabarapl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 117
• Subcellular Localization: Golgi apparatus. Cytoplasmic vesicle, autophagosome.
• Protein Description: Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation..
• Protein Sequence: MKWMFKEDHSLEHRCVESAKIRAKYPDRVPVIVEKVSGSQIVDIDKRKYLVPSDITVAQFMWIIRKRIQLPSEKAIFLFVDKTVPQSSLTMGQLYEKEKDEDGFLYVAYSGENTFGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	WMFKEDHSLEHRCVE CCCCCCCCCCHHHHH	48.01	25521595
15	Glutathionylation	DHSLEHRCVESAKIR CCCCCHHHHHHHCHH	4.26	24333276
24	Acetylation	ESAKIRAKYPDRVPV HHHCHHHHCCCCCCE	47.68	-
24	Ubiquitination	ESAKIRAKYPDRVPV HHHCHHHHCCCCCCE	47.68	-
25	Phosphorylation	SAKIRAKYPDRVPVI HHCHHHHCCCCCCEE	14.91	25195567
35	Acetylation	RVPVIVEKVSGSQIV CCCEEEEECCCCCEE	30.70	129673
39	Phosphorylation	IVEKVSGSQIVDIDK EEEECCCCCEEECCC	14.82	-
74	Ubiquitination	RIQLPSEKAIFLFVD HCCCCCCCEEEEEEE	51.63	-
116	Phosphatidylethanolamine amidation	YSGENTFGF------ ECCCCCCCC------	25.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBRL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.