GBRG2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRG2_RAT
• UniProt AC: P18508
• Protein Name: Gamma-aminobutyric acid receptor subunit gamma-2
• Gene Name: Gabrg2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 466
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cytoplasmic vesicle membrane .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
• Protein Sequence: MSSPNTWSTGSTVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	DYEDYASNKTWVLTP CHHHHHHCCEEEECC	37.29	-
128	N-linked_Glycosylation	YDRRLKFNSTIKVLR HHHHHHCCCEEEEEE	36.33	-
246	N-linked_Glycosylation	FSFVGLRNTTEVVKT EEEECCCCCEEEEEE	57.29	-
365	Phosphorylation	FVSNRKPSKDKDKKK HHCCCCCCCCCCCCC	57.43	-
403	Phosphorylation	LQERDEEYGYECLDG CCCCHHHHCCCCCCC	23.98	11640929
405	Phosphorylation	ERDEEYGYECLDGKD CCHHHHCCCCCCCCC	11.54	11640929

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBRG2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRG2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRG2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRG2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.