dbPTM

GBRAP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GBRAP_MOUSE
UniProt AC	Q9DCD6
Protein Name	Gamma-aminobutyric acid receptor-associated protein
Gene Name	Gabarap
Organism	Mus musculus (Mouse).
Sequence Length	117
Subcellular Localization	Endomembrane system. Cytoplasm, cytoskeleton . Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle . Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Co
Protein Description	Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)..
Protein Sequence	MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	KEEHPFEKRRSEGEK CCCCCCHHCCCHHHH	54.19	22790023
23	Ubiquitination	SEGEKIRKKYPDRVP CHHHHHHHHCCCCCC	61.20	-
24	Ubiquitination	EGEKIRKKYPDRVPV HHHHHHHHCCCCCCE	52.76	22790023
35	Acetylation	RVPVIVEKAPKARIG CCCEEEEECCCCCCC	60.12	130601
116	Phosphatidylethanolamine amidation	YSDESVYGL------ ECCCCCCCC------	23.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GBRAP_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GBRAP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GBRAP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
CALR_MOUSE	Calr	physical	17916189

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GBRAP_MOUSE

Related Literatures of Post-Translational Modification