GBRA1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRA1_RAT
• UniProt AC: P62813
• Protein Name: Gamma-aminobutyric acid receptor subunit alpha-1
• Gene Name: Gabra1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 455
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .
• Protein Description: Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel..
• Protein Sequence: MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	N-linked_Glycosylation	SQDELKDNTTVFTRI CHHHHCCCCHHHHHH	35.74	-
137	N-linked_Glycosylation	GKKSVAHNMTMPNKL CCCCCCCCCCCCCCE	20.20	-
366	Phosphorylation	PLIKKNNTYAPTATS CCCCCCCCCCCCCCC	30.38	16641100
367	Phosphorylation	LIKKNNTYAPTATSY CCCCCCCCCCCCCCC	16.83	-
374	Phosphorylation	YAPTATSYTPNLARG CCCCCCCCCCCCCCC	23.12	-
375	Phosphorylation	APTATSYTPNLARGD CCCCCCCCCCCCCCC	12.88	17013930
390	Ubiquitination	PGLATIAKSATIEPK CCCCHHHHCCCCCCC	36.45	-
400	Ubiquitination	TIEPKEVKPETKPPE CCCCCCCCCCCCCCC	37.92	-
404	Ubiquitination	KEVKPETKPPEPKKT CCCCCCCCCCCCCCC	57.84	-
410	Ubiquitination	TKPPEPKKTFNSVSK CCCCCCCCCCCCCHH	69.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
375	T	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRA1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRA1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GBRA1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.