GBGE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBGE_DROME
• UniProt AC: Q9NFZ3
• Protein Name: Guanine nucleotide-binding protein subunit gamma-e
• Gene Name: Ggamma30A {ECO:0000312|FlyBase:FBgn0267252}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 72
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye..
• Protein Sequence: MDPSALQNMDRDALKKQIENMKYQASMERWPLSKSIAEMRSFIEENEKNDPLINAPDKKNNPWAEKGKCVIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MDPSALQNM ------CCHHHHHHC	45.95	15205461
26	Phosphorylation	ENMKYQASMERWPLS HHHHHHHHHHHCCCH	12.97	27794539
41	Phosphorylation	KSIAEMRSFIEENEK HHHHHHHHHHHHHHC	29.30	27794539
69	Methylation	PWAEKGKCVIM---- CCHHCCCEEEC----	3.23	15205461
69	Farnesylation	PWAEKGKCVIM---- CCHHCCCEEEC----	3.23	15205461
69	Farnesylation	PWAEKGKCVIM---- CCHHCCCEEEC----	3.23	15205461

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GBGE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBGE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBGE_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of GBGE_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Targeted mutagenesis of the farnesylation site of Drosophila Ggammaedisrupts membrane association of the G protein betagamma complex andaffects the light sensitivity of the visual system.";
Schillo S., Belusic G., Hartmann K., Franz C., Kuhl B.,Brenner-Weiss G., Paulsen R., Huber A.;
J. Biol. Chem. 279:36309-36316(2004).
Cited for: ACETYLATION AT ASP-2, ISOPRENYLATION AT CYS-69, METHYLATION AT CYS-69,AND MUTAGENESIS OF CYS-69.
PubMed: 15205461

Methylation

"Targeted mutagenesis of the farnesylation site of Drosophila Ggammaedisrupts membrane association of the G protein betagamma complex andaffects the light sensitivity of the visual system.";
Schillo S., Belusic G., Hartmann K., Franz C., Kuhl B.,Brenner-Weiss G., Paulsen R., Huber A.;
J. Biol. Chem. 279:36309-36316(2004).
Cited for: ACETYLATION AT ASP-2, ISOPRENYLATION AT CYS-69, METHYLATION AT CYS-69,AND MUTAGENESIS OF CYS-69.
PubMed: 15205461

Prenylation

"Targeted mutagenesis of the farnesylation site of Drosophila Ggammaedisrupts membrane association of the G protein betagamma complex andaffects the light sensitivity of the visual system.";
Schillo S., Belusic G., Hartmann K., Franz C., Kuhl B.,Brenner-Weiss G., Paulsen R., Huber A.;
J. Biol. Chem. 279:36309-36316(2004).
Cited for: ACETYLATION AT ASP-2, ISOPRENYLATION AT CYS-69, METHYLATION AT CYS-69,AND MUTAGENESIS OF CYS-69.
PubMed: 15205461