GATM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATM_MOUSE
• UniProt AC: Q9D964
• Protein Name: Glycine amidinotransferase, mitochondrial
• Gene Name: Gatm
• Organism: Mus musculus (Mouse).
• Sequence Length: 423
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development..
• Protein Sequence: MLRVRCLRGGSRGAEAVHYIGSRLGGSLTGWVQRTFQSTQAATASSRNSCAAEDKATHPLPKDCPVSSYNEWDPLEEVIVGRAENACVPPFTVEVKANTYEKYWPFYQKNGGLYFPKDHLKKAVAEVEEMCNILSMEGVTVRRPDPIDWSLKYKTPDFESTGLYSAMPRDILMVVGNEIIEAPMAWRSRFFEYRAYRSIIKDYFHRGAKWTTAPKPTMADELYDQNYPIHSVEDRHKLAAQGKFVTTEFEPCFDAADFIRAGRDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFKDPNPMHIDATFNIIGPGLVLSNPDRPCHQIDLFKKAGWTIVTPPTPVIPDDHPLWMSSKWLSMNVLMLDEKRVMVDANEVPIQKMFEKLGISTIKVNIRNANSLGGGFHCWTCDVRRRGTLQSYFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	TQAATASSRNSCAAE HHHHHHHCCCCCCCC	32.77	-
49	Phosphorylation	ATASSRNSCAAEDKA HHHHCCCCCCCCCCC	12.20	-
50	Glutathionylation	TASSRNSCAAEDKAT HHHCCCCCCCCCCCC	4.80	24333276
64	Glutathionylation	THPLPKDCPVSSYNE CCCCCCCCCCCCCCC	4.47	24333276
131	Glutathionylation	VAEVEEMCNILSMEG HHHHHHHHCCCCEEC	3.03	24333276
135	Phosphorylation	EEMCNILSMEGVTVR HHHHCCCCEECCEEE	15.81	26643407
140	Phosphorylation	ILSMEGVTVRRPDPI CCCEECCEEECCCCC	21.10	26643407
154	Ubiquitination	IDWSLKYKTPDFEST CCEEEEECCCCHHHC	52.58	22790023
212	Phosphorylation	HRGAKWTTAPKPTMA HCCCCCCCCCCCCCH	39.59	-
223	Phosphorylation	PTMADELYDQNYPIH CCCHHHHHCCCCCCC	17.27	-
381	Acetylation	ANEVPIQKMFEKLGI CCCCCHHHHHHHHCC	46.40	23806337
381	Succinylation	ANEVPIQKMFEKLGI CCCCCHHHHHHHHCC	46.40	23806337
385	Acetylation	PIQKMFEKLGISTIK CHHHHHHHHCCCEEE	40.52	-
407	Glutathionylation	SLGGGFHCWTCDVRR CCCCCEEEEECCCCC	2.76	24333276
417	Phosphorylation	CDVRRRGTLQSYFD- CCCCCCCCHHHHCC-	21.58	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GATM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GATM_HUMAN	GATM	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-417, AND MASSSPECTROMETRY.
PubMed: 17242355