GATA2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GATA2_RAT
• UniProt AC: Q924Y4
• Protein Name: Endothelial transcription factor GATA-2
• Gene Name: Gata2 {ECO:0000312|EMBL:AAK51128.1}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 480
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection..
• Protein Sequence: MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	ARARVSYSPAHARLT HHCCEECCCCHHHCC	14.22	-
86	Asymmetric dimethylarginine	LTGGQMCRPHLLHSP CCCCCCCCCHHCCCC	19.14	-
86	Methylation	LTGGQMCRPHLLHSP CCCCCCCCCHHCCCC	19.14	-
192	Phosphorylation	PSTTGAASPASPSAG CCCCCCCCCCCCCCC	22.06	-
195	Phosphorylation	TGAASPASPSAGGSV CCCCCCCCCCCCCCC	23.83	22108457
197	Phosphorylation	AASPASPSAGGSVAR CCCCCCCCCCCCCCC	36.73	22108457
409	Acetylation	SKSKKSKKGAECFEE CCCHHHHHHHHHHHH	71.14	26302492
419	Acetylation	ECFEELSKCMQEKSS HHHHHHHHHHHHCCC	46.48	26302492
424	Acetylation	LSKCMQEKSSPFSAA HHHHHHHCCCHHHHH	39.06	26302492

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GATA2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GATA2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GATA2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of GATA2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.