GARL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GARL3_HUMAN
• UniProt AC: Q5VVW2
• Protein Name: GTPase-activating Rap/Ran-GAP domain-like protein 3
• Gene Name: GARNL3
• Organism: Homo sapiens (Human).
• Sequence Length: 1013
• Protein Sequence: MVVDFCRRFVARSLCIILMKHFCSSSVSEDLGCRRGDFSRKHYGSVELLISSDADGAIQRAGRFRVENGSSDENATALPGTWRRTDVHLENPEYHTRWYFKYFLGQVHQNYIGNDAEKSPFFLSVTLSDQNNQRVPQYRAILWRKTGTQKICLPYSPTKTLSVKSILSAMNLDKFEKGPREIFHPEIQKDLLVLEEQEGSVNFKFGVLFAKDGQLTDDEMFSNEIGSEPFQKFLNLLGDTITLKGWTGYRGGLDTKNDTTGIHSVYTVYQGHEIMFHVSTMLPYSKENKQQVERKRHIGNDIVTIVFQEGEESSPAFKPSMIRSHFTHIFALVRYNQQNDNYRLKIFSEESVPLFGPPLPTPPVFTDHQEFRDFLLVKLINGEKATLETPTFAQKRRRTLDMLIRSLHQDLMPDLHKNMLNRRSFSDVLPESPKSARKKEEARQAEFVRIGQALKLKSIVRGDAPSSLAASGICKKEPWEPQCFCSNFPHEAVCADPWGQALLVSTDAGVLLVDDDLPSVPVFDRTLPVKQMHVLETLDLLVLRADKGKDARLFVFRLSALQKGLEGKQAGKSRSDCRENKLEKTKGCHLYAINTHHSRELRIVVAIRNKLLLITRKHNKPSGVTSTSLLSPLSESPVEEFQYIREICLSDSPMVMTLVDGPAEESDNLICVAYRHQFDVVNESTGEAFRLHHVEANRVNFVAAIDVYEDGEAGLLLCYNYSCIYKKVCPFNGGSFLVQPSASDFQFCWNQAPYAIVCAFPYLLAFTTDSMEIRLVVNGNLVHTAVVPQLQLVASRSDIYFTATAAVNEVSSGGSSKGASARNSPQTPPGRDTPVFPSSLGEGEIQSKNLYKIPLRNLVGRSIERPLKSPLVSKVITPPTPISVGLAAIPVTHSLSLSRMEIKEIASRTRRELLGLSDEGGPKSEGAPKAKSKPRKRLEESQGGPKPGAVRSSSSDRIPSGSLESASTSEANPEGHSASSDQDPVADREGSPVSGSSPFQLTAFSDEDIIDLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	CRRFVARSLCIILMK HHHHHHHHHHHHHHH	20.18	25690035
25	Phosphorylation	LMKHFCSSSVSEDLG HHHHHHCCCCHHHCC	35.62	-
26	Phosphorylation	MKHFCSSSVSEDLGC HHHHHCCCCHHHCCC	17.23	-
45	Phosphorylation	FSRKHYGSVELLISS CCCCCCCEEEEEEEC	12.78	28348404
51	Phosphorylation	GSVELLISSDADGAI CEEEEEEECCCCCHH	23.33	-
52	Phosphorylation	SVELLISSDADGAIQ EEEEEEECCCCCHHH	29.80	-
124	Phosphorylation	EKSPFFLSVTLSDQN CCCCEEEEEEECCCC	14.11	24719451
126	Phosphorylation	SPFFLSVTLSDQNNQ CCEEEEEEECCCCCC	19.71	24719451
128	Phosphorylation	FFLSVTLSDQNNQRV EEEEEEECCCCCCCC	27.99	24719451
155	Phosphorylation	TQKICLPYSPTKTLS CCEEECCCCCCCCCC	17.84	-
156	Phosphorylation	QKICLPYSPTKTLSV CEEECCCCCCCCCCH	24.93	-
158	Phosphorylation	ICLPYSPTKTLSVKS EECCCCCCCCCCHHH	30.62	-
165	Phosphorylation	TKTLSVKSILSAMNL CCCCCHHHHHHHCCH	26.97	22210691
168	Phosphorylation	LSVKSILSAMNLDKF CCHHHHHHHCCHHHH	24.65	24719451
240	Phosphorylation	FLNLLGDTITLKGWT HHHHHCCEEEEECCC	17.67	24114839
242	Phosphorylation	NLLGDTITLKGWTGY HHHCCEEEEECCCCC	25.22	24114839
259	Phosphorylation	GLDTKNDTTGIHSVY CCCCCCCCCCCCEEE	35.99	28348404
260	Phosphorylation	LDTKNDTTGIHSVYT CCCCCCCCCCCEEEE	36.68	28348404
267	Phosphorylation	TGIHSVYTVYQGHEI CCCCEEEEEECCCEE	15.58	28348404
269	Phosphorylation	IHSVYTVYQGHEIMF CCEEEEEECCCEEEE	10.85	28348404
284	Phosphorylation	HVSTMLPYSKENKQQ EEHHCCCCCHHHHHH	28.54	24719451
285	Phosphorylation	VSTMLPYSKENKQQV EHHCCCCCHHHHHHH	31.39	24719451
389	Phosphorylation	GEKATLETPTFAQKR CCCCCCCCCCHHHHH	30.64	23917254
395	Acetylation	ETPTFAQKRRRTLDM CCCCHHHHHHHHHHH	44.43	26822725
399	Phosphorylation	FAQKRRRTLDMLIRS HHHHHHHHHHHHHHH	25.87	-
424	Phosphorylation	KNMLNRRSFSDVLPE HHHHHCCCHHHHCCC	26.35	29978859
426	Phosphorylation	MLNRRSFSDVLPESP HHHCCCHHHHCCCCC	28.23	29978859
432	Phosphorylation	FSDVLPESPKSARKK HHHHCCCCCCHHHHH	35.37	21815630
591	Phosphorylation	KTKGCHLYAINTHHS HCCCCEEEEEECCCC	5.03	29052541
595	Phosphorylation	CHLYAINTHHSRELR CEEEEEECCCCCHHH	18.17	29052541
617	Acetylation	KLLLITRKHNKPSGV EEEEEECCCCCCCCC	42.77	164389
817	Ubiquitination	VSSGGSSKGASARNS CCCCCCCCCCCCCCC	61.26	-
820	Phosphorylation	GGSSKGASARNSPQT CCCCCCCCCCCCCCC	36.11	-
824	Phosphorylation	KGASARNSPQTPPGR CCCCCCCCCCCCCCC	16.90	27251275
827	Phosphorylation	SARNSPQTPPGRDTP CCCCCCCCCCCCCCC	34.53	21082442
869	Phosphorylation	SIERPLKSPLVSKVI CCCCCCCCCCCCCCC	31.02	27251275
892	Phosphorylation	GLAAIPVTHSLSLSR EEEECCCCCCCCCCH	10.61	28348404
894	Phosphorylation	AAIPVTHSLSLSRME EECCCCCCCCCCHHH	15.41	28348404
896	Phosphorylation	IPVTHSLSLSRMEIK CCCCCCCCCCHHHHH	27.58	24719451
898	Phosphorylation	VTHSLSLSRMEIKEI CCCCCCCCHHHHHHH	26.63	27251275
965	Phosphorylation	IPSGSLESASTSEAN CCCCCCCCCCCCCCC	32.58	27732954
967	Phosphorylation	SGSLESASTSEANPE CCCCCCCCCCCCCCC	41.57	27732954
968	Phosphorylation	GSLESASTSEANPEG CCCCCCCCCCCCCCC	30.24	27732954
969	Phosphorylation	SLESASTSEANPEGH CCCCCCCCCCCCCCC	32.01	27732954
977	Phosphorylation	EANPEGHSASSDQDP CCCCCCCCCCCCCCC	40.48	27732954
979	Phosphorylation	NPEGHSASSDQDPVA CCCCCCCCCCCCCCC	37.15	27732954
980	Phosphorylation	PEGHSASSDQDPVAD CCCCCCCCCCCCCCC	38.72	27732954
991	Phosphorylation	PVADREGSPVSGSSP CCCCCCCCCCCCCCC	19.85	27732954
994	Phosphorylation	DREGSPVSGSSPFQL CCCCCCCCCCCCCEE	36.02	27732954
996	Phosphorylation	EGSPVSGSSPFQLTA CCCCCCCCCCCEEEE	27.60	27732954
997	Phosphorylation	GSPVSGSSPFQLTAF CCCCCCCCCCEEEEC	33.00	27732954
1002	Phosphorylation	GSSPFQLTAFSDEDI CCCCCEEEECCCCCC	18.18	27732954
1005	Phosphorylation	PFQLTAFSDEDIIDL CCEEEECCCCCCCCC	37.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GARL3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GARL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GARL3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of GARL3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-827, AND MASSSPECTROMETRY.
PubMed: 17081983