GAP2_DROME - dbPTM
GAP2_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GAP2_DROME
UniProt AC Q8T498
Protein Name Probable Ras GTPase-activating protein
Gene Name CG42684
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1580
Subcellular Localization Cytoplasm.
Protein Description Probable GTPase-activating protein, which may act as a negative regulator for some member of the Ras family. They decrease the signaling activity of Ras by stimulating its intinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras (By similarity)..
Protein Sequence MGRRTYLSRSSTISYPSRIEGWLDVCETEGELTRLIKTLPWGPLYCVLQQDDQTFTAYCSEEISLGDVCYEDIPRVRLDRVRRPAKALWDGPPTLVEENEDSDSCVGGSGGMSGINDIVLNTTLYSELGEYKSKTLPRIHFDTALNDTSLNEDTSYEKACRRGSAPTTPILGSKQHQTEHNATSRFTNFFSKKSNPLKRTKSVTKLERTKRGSGGLRGSRSHESLLSSHAVMSTIDLSCTGAVGVAPVHQSVLGRRHCFQVRGGPRGERYYSCGSRQERDLWIYSLRKSIAPNAEHTRRTDNSLKMWVYEAKNLPPKKRYFCELQLDKTLYGRTSVKLQTDLLFWGEHFDFPDIPEINVITVNVFREVDKKKKRDKYQFVGSVKIPVHDVTSRLPCEQWYPILSDKAGDSLGRTSGGGGSGSKDKEQLPTLRIKCRFQSTDILPINVYGNFLTYLKENYKRVCETLEPVIGVKAKEDIGQALVLLMHAQGLAGAFLTDVVALDLLRVGDQRLTFRGNSLATKSMEAFLKLTGEQYLQDTLSAPINELIQSERDCEVDPTKTSGSSAGSLQRQQAALRGAVRGAWQCIFESHKHFPAQLRNCFATFRERLQQLGRQDMADNLISASIFLRFLCPAILSPSLFNITSELPSARATRNLTLVAKTLQTLANFTRFQGKENFMEFLNDFLEQEAARMQQFLEIISTRPEHPAPDSILDWAGYIDQGKQLSILHSLLSESLAKLPEARQHELDPLQHILDEISRAKEHGMGTALPGGYLPATSSTHSIASENQENRNPGSSGSHAGSNSEQLLPQQSQLAQPQHAIVSKPLSAERGIMRGVLTPNSLEKNIFRYNDPTVNGLLQQQQQQQQQQQQQQQQHQQLQQHGHQQQPHHQHPLQMLSNSQTSIAGNQYMSSPGGLQHAQSQTSMASSSLNGSSSNLLHGHQQHAHHPQQLHPHHCPPAPQTSASSTMERMDRMNYPYMSHNGNDYETSTPSSTRSRTLPRNGNPNANGNVGSSNNNQSGSYDDMHGEFQIQISGFDTSSAFVCKSPTPMMKSSLGPAGAGRSHHKLNLGIPDHSGGYVRGNNLNPNSNMPKNLEDLDDLFKYAEEHDVAEPANHHNHNQGQQNHQGHLKPAAVPGKEQLSAKSSHCSSGYQSISTNPSPSQSSSPVESQLKAAMGSHNAPLAFKNPSYQLQPQTGSSRSSAQSNTHQQQQQQQQQQFGSRLKPIGGGLVAARAAFLNSGGALEAATLTPSSSDEQLSADNYFSYAAAAAAGAGIATKLEAQRSLSGGSSSSTSASASTSNLGKSGGSSAYGRLNGPLKREDVYGSGYGGSSGNVGYGLSTSSAAGHHQHPHQQQQNPMQQQQQRERDQEHKQYAGSVAGSVGSATSAAQRRLSLDSARTLSDSSTDTEGHCNQLQEGKRRRQLRSSGGSGGGGAGSEQGLGKSYDQNGEIQLLQQTLDTLCHTLDRDEAELRDSSDELFGLQRPAGSNGSNNLSLQSESTMRSIIDRLITMEEELRREQLKMSLALSHKQRVIEEQGQQIAALDAANSRLLSALTALRQRYETQQQQQQHQAPPKTQKPQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
140PhosphorylationSKTLPRIHFDTALND
CCCCCEEEECCCCCC		18.7918327897
143PhosphorylationLPRIHFDTALNDTSL
CCEEEECCCCCCCCC		31.9118327897
164PhosphorylationEKACRRGSAPTTPIL
HHHHHCCCCCCCCCC		29.3019429919
167PhosphorylationCRRGSAPTTPILGSK
HHCCCCCCCCCCCCC		44.9419429919
168PhosphorylationRRGSAPTTPILGSKQ
HCCCCCCCCCCCCCH		13.7919429919
197PhosphorylationFSKKSNPLKRTKSVT
HCCCCCCCCCCCCCC		7.3918327897
200PhosphorylationKSNPLKRTKSVTKLE
CCCCCCCCCCCCCHH		26.5318327897
221PhosphorylationGGLRGSRSHESLLSS
CCCCCCCCHHHHHHH		33.0518327897
224PhosphorylationRGSRSHESLLSSHAV
CCCCCHHHHHHHCCC		29.2318327897
568PhosphorylationTSGSSAGSLQRQQAA
CCCCCHHHHHHHHHH		22.5021082442
838PhosphorylationGIMRGVLTPNSLEKN
CCCCCCCCCCHHHCC		20.3021082442
1052PhosphorylationSPTPMMKSSLGPAGA
CCCCCCCCCCCCCCC		16.9521082442
1053PhosphorylationPTPMMKSSLGPAGAG
CCCCCCCCCCCCCCC		31.6521082442
1134PhosphorylationHLKPAAVPGKEQLSA
CCCCCCCCCHHHHCC		43.3318327897
1140PhosphorylationVPGKEQLSAKSSHCS
CCCHHHHCCCCCCCC		33.0918327897
1158PhosphorylationQSISTNPSPSQSSSP
CCCCCCCCCCCCCCC		38.9718327897
1164PhosphorylationPSPSQSSSPVESQLK
CCCCCCCCCHHHHHH		37.9118327897
1199PhosphorylationPQTGSSRSSAQSNTH
CCCCCCCHHHHHHHH		31.7921082442
1200PhosphorylationQTGSSRSSAQSNTHQ
CCCCCCHHHHHHHHH		29.2621082442
1377PhosphorylationHKQYAGSVAGSVGSA
HHHHHHHHHHHHHHH		7.3718327897
1379PhosphorylationQYAGSVAGSVGSATS
HHHHHHHHHHHHHHH		22.2518327897
1393PhosphorylationSAAQRRLSLDSARTL
HHHHHHHCHHCCCCC		28.4619429919
1396PhosphorylationQRRLSLDSARTLSDS
HHHHCHHCCCCCCCC		25.5819429919
1401PhosphorylationLDSARTLSDSSTDTE
HHCCCCCCCCCCCCC		34.5318327897
1403PhosphorylationSARTLSDSSTDTEGH
CCCCCCCCCCCCCCH		31.5912537569
1425PhosphorylationKRRRQLRSSGGSGGG
HHHHHHHHCCCCCCC		41.7619060867
1426PhosphorylationRRRQLRSSGGSGGGG
HHHHHHHCCCCCCCC		40.5125749252
1429PhosphorylationQLRSSGGSGGGGAGS
HHHHCCCCCCCCCCC		37.4829892262
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GAP2_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GAP2_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GAP2_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ORB2_DROMEorb2physical
14605208
MED4_DROMEMED4physical
14605208
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GAP2_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-164; THR-167; SER-221;SER-224; SER-1158; SER-1164; SER-1401 AND SER-1403, AND MASSSPECTROMETRY.

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