dbPTM

GAP2_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GAP2_CAEEL
UniProt AC	Q8MLZ5
Protein Name	Ras GTPase-activating protein gap-2
Gene Name	gap-2
Organism	Caenorhabditis elegans.
Sequence Length	1207
Subcellular Localization	Cytoplasm.
Protein Description	GTPase-activating protein, which acts as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. The different isoforms may play a distinct role in specific tissues..
Protein Sequence	MKVIDEKPEDEEEEKDSGSKCKTPSSCTKKRVREKEEDLPPICHGWLIVCEGNPTKMMNKEVKLPWHAGYCVFEPRQSTMSCYKQEYPFIAGRMLHRNRTVRMDGDRSAFARHWGLLPEHYPSPPITGPHTIARSYTRPPKDRLPTKERFFSISRIPSRLTKFSTVRGMSIEFFDAIHDETNSGGAQVGGESLDRRGWSGASTGNRTTLTASVHNNLMNGRMSSSSHNLSTRLSGSTQNLNQPTNAYGNLLSRPFRSNPLKRTKSVSKMEKSLAEANQHSLHRVDASNTPSRDSSLYAQPPARRHLSQPAREGSLRACRSHESLLSSAHSTHMIELNEDNRLHPVHPSIFEVPNCFRLASTYYSCRTPLERAKWMENLRKTMNPRRDQQRRTENSMLIWILEAKGLPAKRKYYCEMTLDKTLYAKTSSKARTDNVFWGENFEFMMLPKIDEVCVSLFRESDSKKKKDTLIGYVTIGIDQLSSRSPVERWYTVNTSHSDSGTSRIASALGGKSSSQESPSLRIKARWQSVHILPLRAYDNLLETLCYNYLPLCEQLEPVLNVRDKEDLATSLVRVMYKHNLAKEFLCDLIMKEVEKLDNDHLMFRGNTLATKAMESFMKLVADDYLDSTLSDFIKTVLQCEDSCEVDPQKLGNVSNSSLEKNRALLMRYVEVAWTKILNNVHQLPKNLRDVFSALRCRLEAQNREALADTLISSSIFLRFLCPAILSPSLFNLVSEYPSPTNARNLTLIAKTLQNLANFSKFGGKEPHMEFMNEFVDREWHRMKDFLLRISSESKSGPEKNADAIVDAGKELSLIATYLEEAWTPLLQEKNGNKHPLSNVKSVLSELAECKRRSDNGVFHSPMVQQPSSDYENSPQQHVVPRHENVPAYRSTPPTGQATVLGRSTNRPATHLLTSDDYVLSSAFQTPSLRPGGTRLSDETGTSSSRTSDKTTSSAEIRDDTDSDFELREDRGRGGRNRKRLPRTDASPSSSQQASSGYLSNNPSRSSYSNSSSSSPVERMAALSIANPVFGPGPSSGYAIPAEPKEIVYQKRASPPPYDPDVHNYHYQPMQVYAVPPDCQVSPRTQATGGVNAQNRLSLPRTNPRASRNSTLLRPSVVNVPDDWDRTSDYWRDRGENNYRSQLESQVESQAREIERLMRENIELKSKMMSSTKTVDSKRSDSGASEDSYDSLSSLDRPSRQSLVVVPN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
917	Phosphorylation	HLLTSDDYVLSSAFQ EEECCCCEEECCCCC	14.31	27067626

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GAP2_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GAP2_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GAP2_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GAP2_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GAP2_CAEEL

Related Literatures of Post-Translational Modification