| UniProt ID | GANC_HUMAN | |
|---|---|---|
| UniProt AC | Q8TET4 | |
| Protein Name | Neutral alpha-glucosidase C | |
| Gene Name | GANC | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 914 | |
| Subcellular Localization | ||
| Protein Description | Has alpha-glucosidase activity.. | |
| Protein Sequence | MEAAVKEEISLEDEAVDKNIFRDCNKIAFYRRQKQWLSKKSTYQALLDSVTTDEDSTRFQIINEASKVPLLAEIYGIEGNIFRLKINEETPLKPRFEVPDVLTSKPSTVRLISCSGDTGSLILADGKGDLKCHITANPFKVDLVSEEEVVISINSLGQLYFEHLQILHKQRAAKENEEETSVDTSQENQEDLGLWEEKFGKFVDIKANGPSSIGLDFSLHGFEHLYGIPQHAESHQLKNTGDGDAYRLYNLDVYGYQIYDKMGIYGSVPYLLAHKLGRTIGIFWLNASETLVEINTEPAVEYTLTQMGPVAAKQKVRSRTHVHWMSESGIIDVFLLTGPTPSDVFKQYSHLTGTQAMPPLFSLGYHQCRWNYEDEQDVKAVDAGFDEHDIPYDAMWLDIEHTEGKRYFTWDKNRFPNPKRMQELLRSKKRKLVVISDPHIKIDPDYSVYVKAKDQGFFVKNQEGEDFEGVCWPGLSSYLDFTNPKVREWYSSLFAFPVYQGSTDILFLWNDMNEPSVFRGPEQTMQKNAIHHGNWEHRELHNIYGFYHQMATAEGLIKRSKGKERPFVLTRSFFAGSQKYGAVWTGDNTAEWSNLKISIPMLLTLSITGISFCGADIGGFIGNPETELLVRWYQAGAYQPFFRGHATMNTKRREPWLFGEEHTRLIREAIRERYGLLPYWYSLFYHAHVASQPVMRPLWVEFPDELKTFDMEDEYMLGSALLVHPVTEPKATTVDVFLPGSNEVWYDYKTFAHWEGGCTVKIPVALDTIPVFQRGGSVIPIKTTVGKSTGWMTESSYGLRVALSTKGSSVGELYLDDGHSFQYLHQKQFLHRKFSFCSSVLINSFADQRGHYPSKCVVEKILVLGFRKEPSSVTTHSSDGKDQPVAFTYCAKTSILSLEKLSLNIATDWEVRII | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 40 | Ubiquitination | QKQWLSKKSTYQALL HHHHHCCHHHHHHHH | 44.66 | - | |
| 93 | Ubiquitination | INEETPLKPRFEVPD ECCCCCCCCCCCCCC | 35.04 | - | |
| 198 | Ubiquitination | DLGLWEEKFGKFVDI HHCHHHHHHCEEEEE | 48.15 | - | |
| 419 | Acetylation | KNRFPNPKRMQELLR CCCCCCHHHHHHHHH | 68.12 | 20167786 | |
| 428 | Acetylation | MQELLRSKKRKLVVI HHHHHHHCCCCEEEE | 50.60 | 12437947 | |
| 428 | Ubiquitination | MQELLRSKKRKLVVI HHHHHHHCCCCEEEE | 50.60 | - | |
| 429 | Acetylation | QELLRSKKRKLVVIS HHHHHHCCCCEEEEC | 56.88 | 12437957 | |
| 453 | Ubiquitination | YSVYVKAKDQGFFVK CEEEEEECCCCEEEE | 44.88 | - | |
| 608 | Phosphorylation | MLLTLSITGISFCGA EEEEEECCCEEECCC | 25.70 | - | |
| 611 | Phosphorylation | TLSITGISFCGADIG EEECCCEEECCCCCC | 18.81 | - | |
| 626 | Phosphorylation | GFIGNPETELLVRWY CCCCCCCHHHHHHHH | 32.94 | - | |
| 707 | Acetylation | VEFPDELKTFDMEDE EECCCHHCCCCCCCC | 45.13 | 30588879 | |
| 750 | Phosphorylation | EVWYDYKTFAHWEGG CCEEEEEEEECCCCC | 21.59 | - | |
| 833 | Ubiquitination | QKQFLHRKFSFCSSV HHHHHHHHHCCHHHH | 34.31 | 21906983 | |
| 872 | Phosphorylation | GFRKEPSSVTTHSSD EECCCCCCCEEECCC | 33.91 | - | |
| 878 | Phosphorylation | SSVTTHSSDGKDQPV CCCEEECCCCCCCCE | 42.66 | - | |
| 888 | Phosphorylation | KDQPVAFTYCAKTSI CCCCEEEEEEECCCE | 14.14 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GANC_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GANC_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GANC_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of GANC_HUMAN !! | ||||
| Kegg Disease | |
|---|---|
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| DrugBank | |
| DB00491 | Miglitol |
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