dbPTM

FYV1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FYV1_MOUSE
UniProt AC	Q9Z1T6
Protein Name	1-phosphatidylinositol 3-phosphate 5-kinase
Gene Name	Pikfyve
Organism	Mus musculus (Mouse).
Sequence Length	2097
Subcellular Localization	Cytoplasmic vesicle membrane Peripheral membrane protein . Endosome membrane. Associated with vesicle structures. Displays a peripheral vesicular punctate pattern. Mainly associated with membranes of the late endocytic pathway (By similarity)..
Protein Description	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole..
Protein Sequence	MATDDKSSPTLDSANDLPRSPASPSHLTHFKPLTPDQDEPPFKSAYSSFVNLFRFNKERGEGGQGEQQSPSSSWASPQIPSRTQSVRSPVPYKKQLNEELHRRSSVLDSRRKAEPACGGHDPRTAVQLRSLSTVLKRLKEIMEGKSQDSDLKQYWMPDSQCKECYDCSEKFTTFRRRHHCRLCGQIFCSRCCNQEIPGKFMGYTGDLRACTYCRKIALSYAHSTDSNSIGEDLNALSDSTCSVSILDPSEPRTPVGSRKASRNIFLEDDLAWQSLIHPDSSNSALSTRLVSVQEDAGKSPARNRSASITNLSLDRSGSPMVPSYETSVSPQANRNYIRTETTEDERKILLDSAQLKDLWKKICHHTSGMEFQDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRDEYALYRPLQSTEFSETPSPDSDSVNSVEGHSEPSWFKDIKFDDSDTEQIAEEGDDNLANSASPSKRTSVSSFQSTVDSDSAASISLNVELDNVNFHIKKPSKYPHVPPHPADQKEYLVSDTGGQQLSISDAFIKESLFNRRVEEKSKELPFTPLGWHHNNLELLREENEEKQAMERLLSANHNHMMALLQQLLQNESLSSSWRDIIVSLVCQVVQTVRPDVKHQDDDMDIRQFVHIKKIPGGKKFDSVVVNGFVCTKNIAHKKMNSCIKNPKILLLKCSIEYLYREETKFTCIDPIVLQEREFLKNYVQRIVDVRPTLVLVEKTVSRIAQDMLLEHGITLVINVKSQVLERISRMTQGDLVVSMDQLLTKPHLGTCHKFYMQIFQLPNEQTKTLMFFEGCPQHLGCTIKLRGGSDYELARVKEILIFMICVAYHSQLEISFLMDEFAMPPTLMQSPSFHLLTEGRGEEGASQEQVSGSSLPQDPECPREALSSEDSTLLESRTVLEKGELDNKSIPQAVASLKHQDYTTPTCPAGIPCALFALVPESLLPLHMDQQDAVGNEQPETSQQTDEQQDPKSQMKAFRDPLQDDTGMYVTEEVTSSEDQRKTYALTFKQELKDVILCISPVITFREPFLLTEKGMRCSTRDYFPEQIYWSPLLNKEVKEMESRRKKQLLRDLSGLQGMNGSVQAKSIQVLPSHELVSTRIAEHLGDSQTLGRMLADYRARGGRIQSKHLDPFVHSKDASCTSGGKSGNKTESDEERGLIPSDVIWPTKVDCLNPANHQRLCVLFSSSSAQSSNAPSACVSPWIVTMEFYGKNDLTLGIFLERYCFRSSYQCPSMFCDTPMVHHIRRFVHGQGCVQIILKELDSPVPGYQHTILTYSWCRICKQVTPVVALSNESWSMSFAKYLELRFYGHQYTRRANAEPCGHSIHHDYHQYFSYNQMVASFSYSPIRLLEVCVPLPKIFIKRQAPLKVSLLQDLKDFFQKVSQVYLAVDERLASLKTDTFSKTREEKMEDIFAQKEMEEGEFKNWTEKMQARLMSSSVDTPQQLQSIFESLIAKKQSLCEVLQAWNSRLQDLFQQEKGRKRPSVPPSPGRLRQGEESKINAMDTSPRNISPGLHNGEKEDRFLTTLSSQSSTSSTHLQLPTPPEALAEQVVGGPTDLDSASGSEDVFDGHLLGSTDSQVKEKSTMKAIFANLLPGNSYNPIPFPFDPDKHYLMYEHERVPIAVCEKEPSSIIAFALSCKEYRNALEELSKATLRNSAEEGLPANSALDNRPKSSSPIRLPEISGGQTNRTVEAEPQPTKKASGMLSFFRGTAGKSPDLSSQKRETLRGADSAYYQVGQAGKEGLESQGLEPQDEVDGGDTQKKQLTNPHVELQFSDANAKFYCRLYYAGEFHKMREVILGSSEEEFIRSLSHSSPWQARGGKSGAAFYATEDDRFILKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENLFYGRKMAQVFDLKGSLRNRNVKTDTGKESCDVVLLDENLLKMVRDNPLYIRSHSKSVLRTSIHSDAHFLSSHLIIDYSLLVGRDDTSNELVVGIIDYIRTFTWDKKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDKYFLMVPDHWTGLDLNC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATDDKSSP ------CCCCCCCCC	30.92	-
3	Phosphorylation	-----MATDDKSSPT -----CCCCCCCCCC	57.50	22006019
7	Phosphorylation	-MATDDKSSPTLDSA -CCCCCCCCCCCCCC	48.85	25521595
8	Phosphorylation	MATDDKSSPTLDSAN CCCCCCCCCCCCCCC	27.87	26824392
10	Phosphorylation	TDDKSSPTLDSANDL CCCCCCCCCCCCCCC	45.18	26643407
13	Phosphorylation	KSSPTLDSANDLPRS CCCCCCCCCCCCCCC	31.89	29472430
20	Phosphorylation	SANDLPRSPASPSHL CCCCCCCCCCCCHHC	23.91	30635358
23	Phosphorylation	DLPRSPASPSHLTHF CCCCCCCCCHHCCCC	30.25	26824392
25	Phosphorylation	PRSPASPSHLTHFKP CCCCCCCHHCCCCCC	28.74	26643407
28	Phosphorylation	PASPSHLTHFKPLTP CCCCHHCCCCCCCCC	21.60	26643407
34	Phosphorylation	LTHFKPLTPDQDEPP CCCCCCCCCCCCCCC	33.09	26643407
47	Phosphorylation	PPFKSAYSSFVNLFR CCCHHHHHHHHHHHH	19.60	21082442
48	Phosphorylation	PFKSAYSSFVNLFRF CCHHHHHHHHHHHHC	22.12	19060867
69	Phosphorylation	GGQGEQQSPSSSWAS CCCCCCCCCCCCCCC	26.83	26643407
71	Phosphorylation	QGEQQSPSSSWASPQ CCCCCCCCCCCCCCC	42.10	26643407
72	Phosphorylation	GEQQSPSSSWASPQI CCCCCCCCCCCCCCC	33.03	26643407
73	Phosphorylation	EQQSPSSSWASPQIP CCCCCCCCCCCCCCC	30.88	26643407
83	Phosphorylation	SPQIPSRTQSVRSPV CCCCCCCCCCCCCCC	29.54	29472430
85	Phosphorylation	QIPSRTQSVRSPVPY CCCCCCCCCCCCCCC	20.91	29472430
88	Phosphorylation	SRTQSVRSPVPYKKQ CCCCCCCCCCCCHHH	28.26	24899341
104	Phosphorylation	NEELHRRSSVLDSRR CHHHHHHHHHHHHHH	25.42	29472430
105 (in isoform 1)	Phosphorylation	-	25.53	29899451
105	Phosphorylation	EELHRRSSVLDSRRK HHHHHHHHHHHHHHH	25.53	27600695
211	Phosphorylation	TGDLRACTYCRKIAL CCCHHHHHHHHHHHH	25.35	-
212	Phosphorylation	GDLRACTYCRKIALS CCHHHHHHHHHHHHH	7.08	-
253	Phosphorylation	LDPSEPRTPVGSRKA CCCCCCCCCCCCCCC	32.80	19854140
257	Phosphorylation	EPRTPVGSRKASRNI CCCCCCCCCCCCCCE	30.73	19854140
291	Phosphorylation	ALSTRLVSVQEDAGK CCHHEEEEEECCCCC	23.75	25619855
299	Phosphorylation	VQEDAGKSPARNRSA EECCCCCCCCCCCCC	23.91	26824392
305	Phosphorylation	KSPARNRSASITNLS CCCCCCCCCCCEEEE	29.89	24925903
307	Phosphorylation	PARNRSASITNLSLD CCCCCCCCCEEEEEC	31.06	24925903
309	Phosphorylation	RNRSASITNLSLDRS CCCCCCCEEEEECCC	27.84	24925903
312	Phosphorylation	SASITNLSLDRSGSP CCCCEEEEECCCCCC	30.23	24925903
316	Phosphorylation	TNLSLDRSGSPMVPS EEEEECCCCCCCCCC	43.20	24899341
318	Phosphorylation	LSLDRSGSPMVPSYE EEECCCCCCCCCCCC	15.86	24899341
323	Phosphorylation	SGSPMVPSYETSVSP CCCCCCCCCCCCCCC	24.96	29899451
324	Phosphorylation	GSPMVPSYETSVSPQ CCCCCCCCCCCCCCC	19.70	26643407
326	Phosphorylation	PMVPSYETSVSPQAN CCCCCCCCCCCCCCC	26.62	26643407
327	Phosphorylation	MVPSYETSVSPQANR CCCCCCCCCCCCCCC	14.52	28066266
329	Phosphorylation	PSYETSVSPQANRNY CCCCCCCCCCCCCCC	15.86	25521595
336	Phosphorylation	SPQANRNYIRTETTE CCCCCCCCCCCCCCH	6.64	29514104
454	Phosphorylation	TPSPDSDSVNSVEGH CCCCCCCCCCCCCCC	27.44	21183079
457	Phosphorylation	PDSDSVNSVEGHSEP CCCCCCCCCCCCCCC	21.27	21183079
462	Phosphorylation	VNSVEGHSEPSWFKD CCCCCCCCCCCCCCC	63.16	21183079
475	Phosphorylation	KDIKFDDSDTEQIAE CCCCCCCCCHHHHHH	48.56	25521595
477	Phosphorylation	IKFDDSDTEQIAEEG CCCCCCCHHHHHHHC	33.47	25521595
486	Phosphorylation	QIAEEGDDNLANSAS HHHHHCCCCCCCCCC	64.00	24719451
491	Phosphorylation	GDDNLANSASPSKRT CCCCCCCCCCCCCCC	25.23	25619855
493	Phosphorylation	DNLANSASPSKRTSV CCCCCCCCCCCCCCH	29.53	25619855
495	Phosphorylation	LANSASPSKRTSVSS CCCCCCCCCCCCHHH	32.07	25619855
784	Phosphorylation	SQVLERISRMTQGDL HHHHHHHHHCCCCCE	23.40	24759943
902	Phosphorylation	GRGEEGASQEQVSGS CCCCCCCCCHHCCCC	45.14	30635358
907	Phosphorylation	GASQEQVSGSSLPQD CCCCHHCCCCCCCCC	32.43	30635358
909	Phosphorylation	SQEQVSGSSLPQDPE CCHHCCCCCCCCCCC	22.61	30635358
910	Phosphorylation	QEQVSGSSLPQDPEC CHHCCCCCCCCCCCC	47.82	30635358
923	Phosphorylation	ECPREALSSEDSTLL CCCHHHHCCCCCHHH	38.44	30635358
924	Phosphorylation	CPREALSSEDSTLLE CCHHHHCCCCCHHHH	46.39	30635358
927	Phosphorylation	EALSSEDSTLLESRT HHHCCCCCHHHHHCC	19.53	30635358
928	Phosphorylation	ALSSEDSTLLESRTV HHCCCCCHHHHHCCH	47.92	30635358
1146	Phosphorylation	EHLGDSQTLGRMLAD HHHCCCHHHHHHHHH	34.82	25338131
1176	Phosphorylation	FVHSKDASCTSGGKS CCCCCCCCCCCCCCC	28.23	21183079
1178	Phosphorylation	HSKDASCTSGGKSGN CCCCCCCCCCCCCCC	28.10	21183079
1183	Phosphorylation	SCTSGGKSGNKTESD CCCCCCCCCCCCCCH	51.37	26643407
1187	Phosphorylation	GGKSGNKTESDEERG CCCCCCCCCCHHHCC	44.73	26643407
1189	Phosphorylation	KSGNKTESDEERGLI CCCCCCCCHHHCCCC	56.40	27180971
1300	Phosphorylation	IILKELDSPVPGYQH HHHHCCCCCCCCCHH	40.18	22802335
1305	Phosphorylation	LDSPVPGYQHTILTY CCCCCCCCHHEHHHH	7.34	22802335
1308	Phosphorylation	PVPGYQHTILTYSWC CCCCCHHEHHHHHHH	11.36	22802335
1312	Phosphorylation	YQHTILTYSWCRICK CHHEHHHHHHHHHCC	9.20	22802335
1313	Phosphorylation	QHTILTYSWCRICKQ HHEHHHHHHHHHCCC	17.92	22802335
1435	Phosphorylation	ERLASLKTDTFSKTR HHHHHCCCCCCCHHH	45.63	29472430
1437	Phosphorylation	LASLKTDTFSKTREE HHHCCCCCCCHHHHH	34.73	27818261
1439	Phosphorylation	SLKTDTFSKTREEKM HCCCCCCCHHHHHHH	34.90	27818261
1441	Phosphorylation	KTDTFSKTREEKMED CCCCCCHHHHHHHHH	41.96	29472430
1473	Phosphorylation	KMQARLMSSSVDTPQ HHHHHHHCCCCCCHH	24.85	21149613
1474	Phosphorylation	MQARLMSSSVDTPQQ HHHHHHCCCCCCHHH	22.03	21149613
1475	Phosphorylation	QARLMSSSVDTPQQL HHHHHCCCCCCHHHH	19.39	21149613
1478	Phosphorylation	LMSSSVDTPQQLQSI HHCCCCCCHHHHHHH	22.35	21149613
1521	Phosphorylation	EKGRKRPSVPPSPGR HCCCCCCCCCCCCCC	51.82	23684622
1525	Phosphorylation	KRPSVPPSPGRLRQG CCCCCCCCCCCCCCC	33.64	21454597
1542	Phosphorylation	SKINAMDTSPRNISP CCCCCCCCCCCCCCC	27.78	23684622
1543	Phosphorylation	KINAMDTSPRNISPG CCCCCCCCCCCCCCC	20.00	26824392
1548	Phosphorylation	DTSPRNISPGLHNGE CCCCCCCCCCCCCCC	19.23	26824392
1690	Phosphorylation	LEELSKATLRNSAEE HHHHHHHHHHHHHHH	29.95	26060331
1694	Phosphorylation	SKATLRNSAEEGLPA HHHHHHHHHHHCCCC	30.53	26060331
1711	Phosphorylation	ALDNRPKSSSPIRLP CCCCCCCCCCCCCCC	38.44	26643407
1712	Phosphorylation	LDNRPKSSSPIRLPE CCCCCCCCCCCCCCC	46.38	25266776
1713	Phosphorylation	DNRPKSSSPIRLPEI CCCCCCCCCCCCCCC	31.28	22942356
1721	Phosphorylation	PIRLPEISGGQTNRT CCCCCCCCCCCCCCC	34.90	28066266
1725	Phosphorylation	PEISGGQTNRTVEAE CCCCCCCCCCCEECC	29.91	20531401
1740	Phosphorylation	PQPTKKASGMLSFFR CCCCCCCCCCHHHHC	33.35	19060867
1749	Phosphorylation	MLSFFRGTAGKSPDL CHHHHCCCCCCCCCC	28.16	23984901
1753	Phosphorylation	FRGTAGKSPDLSSQK HCCCCCCCCCCCHHH	23.80	26824392
1757	Phosphorylation	AGKSPDLSSQKRETL CCCCCCCCHHHHHHH	37.80	25777480
1758	Phosphorylation	GKSPDLSSQKRETLR CCCCCCCHHHHHHHC	47.20	25266776
1771	Phosphorylation	LRGADSAYYQVGQAG HCCHHHHHHHHHHHH	9.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
48	S	Phosphorylation	Kinase	PRKAA1	Q5EG47	GPS
48	S	Phosphorylation	Kinase	AKT1	P31750	PSP
105	S	Phosphorylation	Kinase	AKT1	P31749	PSP
307	S	Phosphorylation	Kinase	PRKAA1	Q5EG47	GPS
307	S	Phosphorylation	Kinase	AKT1	P31750	PSP
318	S	Phosphorylation	Kinase	AKT1	P31749	PSP
318	S	Phosphorylation	Kinase	AKT1	P31750	Uniprot
318	S	Phosphorylation	Kinase	AKT2	Q60823	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
318	S	Phosphorylation		20513353
Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FYV1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FYV1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FYV1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, AND MASSSPECTROMETRY.	17242355 [Abstract]

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