| UniProt ID | FUT4_HUMAN | |
|---|---|---|
| UniProt AC | P22083 | |
| Protein Name | Alpha-(1,3)-fucosyltransferase 4 | |
| Gene Name | FUT4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 530 | |
| Subcellular Localization |
Golgi apparatus, Golgi stack membrane Single-pass type II membrane protein. Membrane-bound form in trans cisternae of Golgi. |
|
| Protein Description | May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.. | |
| Protein Sequence | MRRLWGAARKPSGAGWEKEWAEAPQEAPGAWSGRLGPGRSGRKGRAVPGWASWPAHLALAARPARHLGGAGQGPRPLHSGTAPFHSRASGERQRRLEPQLQHESRCRSSTPADAWRAEAALPVRAMGAPWGSPTAAAGGRRGWRRGRGLPWTVCVLAAAGLTCTALITYACWGQLPPLPWASPTPSRPVGVLLWWEPFGGRDSAPRPPPDCRLRFNISGCRLLTDRASYGEAQAVLFHHRDLVKGPPDWPPPWGIQAHTAEEVDLRVLDYEEAAAAAEALATSSPRPPGQRWVWMNFESPSHSPGLRSLASNLFNWTLSYRADSDVFVPYGYLYPRSHPGDPPSGLAPPLSRKQGLVAWVVSHWDERQARVRYYHQLSQHVTVDVFGRGGPGQPVPEIGLLHTVARYKFYLAFENSQHLDYITEKLWRNALLAGAVPVVLGPDRANYERFVPRGAFIHVDDFPSASSLASYLLFLDRNPAVYRRYFHWRRSYAVHITSFWDEPWCRVCQAVQRAGDRPKSIRNLASWFER | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 75 | Methylation | GGAGQGPRPLHSGTA CCCCCCCCCCCCCCC | 53.92 | - | |
| 79 | Phosphorylation | QGPRPLHSGTAPFHS CCCCCCCCCCCCCCC | 45.59 | - | |
| 87 | Methylation | GTAPFHSRASGERQR CCCCCCCCCCCHHHH | 24.97 | - | |
| 132 | Phosphorylation | AMGAPWGSPTAAAGG CCCCCCCCCCHHHCC | 18.40 | 28555341 | |
| 216 | N-linked_Glycosylation | PDCRLRFNISGCRLL CCCEEEEEEECCEEE | 22.53 | UniProtKB CARBOHYD | |
| 221 | Methylation | RFNISGCRLLTDRAS EEEEECCEEEECCCC | 35.94 | - | |
| 226 | Methylation | GCRLLTDRASYGEAQ CCEEEECCCCHHHHC | 21.87 | - | |
| 228 | Phosphorylation | RLLTDRASYGEAQAV EEEECCCCHHHHCCE | 34.27 | - | |
| 229 | Phosphorylation | LLTDRASYGEAQAVL EEECCCCHHHHCCEE | 20.28 | - | |
| 240 | Methylation | QAVLFHHRDLVKGPP CCEEEECHHHCCCCC | 30.32 | - | |
| 315 | N-linked_Glycosylation | SLASNLFNWTLSYRA HHHHHHHCEECEEEC | 33.71 | UniProtKB CARBOHYD | |
| 410 | Phosphorylation | TVARYKFYLAFENSQ HHHHHHHHHHCCCCC | 7.93 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FUT4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FUT4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FUT4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FUT4_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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