FTCD_MOUSE - dbPTM
FTCD_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FTCD_MOUSE
UniProt AC Q91XD4
Protein Name Formimidoyltransferase-cyclodeaminase
Gene Name Ftcd
Organism Mus musculus (Mouse).
Sequence Length 541
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus. More abundantly located around the mother centriole..
Protein Description Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity).; Binds and promotes bundling of vimentin filaments originating from the Golgi..
Protein Sequence MSQLVECVPNFSEGNNQEVIDAISRAISQTPGCVLLDVDAGPSTNRTVYTFVGQPECVVEGALHAARTASQLIDMSKHKGEHPRMGALDVCPFIPVRGVSMEECVLCAKAFGQRLAEELNVPVYLYGEAAQTPSRQTLPAIRAGEYEALPEKLKQAEWVPDFGPSSFVPSWGATVTGARKFLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLEEKNLAQVSTNLLDFEVTALHTVFEEARREAQELNLPVVGSQLVGLVPLKALLDAAAFYCDKEKLFVLEEEHRIRLVVNRLGLDSLAPFDPKERIIEYLVPDSGPEQSLLDTSLRGFVREVGARSAAPGGGSVAAAVAALGAALASMVGQMTYGRRQFDHLDSTMRRLIPPFHAASAQLTSLVDADARAFAACLEAIKLPKNTPEERDRRACALQEGLRQAVAVPLKLAETVSQLWPALQELAHCGNLSCLSDLQVAAKALETGVFGAYFNVLINLKDMTDDVFKEKTHHRISSLLQEAKTQAALVLGSLEARKE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSQLVECVP
------CCCCHHCCC		32.0230352176
57S-palmitoylationTFVGQPECVVEGALH
EECCCCHHHHHHHHH		5.4528526873
57S-nitrosylationTFVGQPECVVEGALH
EECCCCHHHHHHHHH		5.4522178444
76PhosphorylationASQLIDMSKHKGEHP
HHHHHHHHHCCCCCC		28.06-
77AcetylationSQLIDMSKHKGEHPR
HHHHHHHHCCCCCCC		42.5723954790
77UbiquitinationSQLIDMSKHKGEHPR
HHHHHHHHCCCCCCC		42.5722790023
91S-palmitoylationRMGALDVCPFIPVRG
CCCCCCCCCCCCCCC		1.9728526873
109UbiquitinationEECVLCAKAFGQRLA
HHHHHHHHHHHHHHH		43.1622790023
132PhosphorylationLYGEAAQTPSRQTLP
EECCCCCCCCCCCCC		20.6430352176
152UbiquitinationEYEALPEKLKQAEWV
CCCCCCHHHHCCCCC		60.0722790023
218UbiquitinationDQPGRLKKVQGIGWY
CCCCCCCCCEECCEE		44.3622790023
286S-palmitoylationLDAAAFYCDKEKLFV
HHHHHHHCCHHHEEE		4.9428526873
288UbiquitinationAAAFYCDKEKLFVLE
HHHHHCCHHHEEEEE		53.8622790023
290AcetylationAFYCDKEKLFVLEEE
HHHCCHHHEEEEEHH		53.6323201123
290UbiquitinationAFYCDKEKLFVLEEE
HHHCCHHHEEEEEHH		53.6322790023
318SuccinylationSLAPFDPKERIIEYL
CCCCCCCHHHHHHHC		62.5623954790
318UbiquitinationSLAPFDPKERIIEYL
CCCCCCCHHHHHHHC		62.56-
334PhosphorylationPDSGPEQSLLDTSLR
CCCCCCCCHHHHHHH		29.2729472430
338PhosphorylationPEQSLLDTSLRGFVR
CCCCHHHHHHHHHHH		29.6321743459
339PhosphorylationEQSLLDTSLRGFVRE
CCCHHHHHHHHHHHH		18.7521743459
419S-palmitoylationDARAFAACLEAIKLP
HHHHHHHHHHHHCCC		2.9428526873
424UbiquitinationAACLEAIKLPKNTPE
HHHHHHHCCCCCCHH		66.83-
424MalonylationAACLEAIKLPKNTPE
HHHHHHHCCCCCCHH		66.8326320211
427MalonylationLEAIKLPKNTPEERD
HHHHCCCCCCHHHHH		81.5226320211
427AcetylationLEAIKLPKNTPEERD
HHHHCCCCCCHHHHH		81.5223954790
438S-nitrosylationEERDRRACALQEGLR
HHHHHHHHHHHHHHH		3.5422178444
438S-palmitoylationEERDRRACALQEGLR
HHHHHHHHHHHHHHH		3.5428526873
511AcetylationDMTDDVFKEKTHHRI
HCCCHHHHHHHHHHH		59.1423954790
513UbiquitinationTDDVFKEKTHHRISS
CCHHHHHHHHHHHHH		54.4722790023
519PhosphorylationEKTHHRISSLLQEAK
HHHHHHHHHHHHHHH		18.1922324799
520PhosphorylationKTHHRISSLLQEAKT
HHHHHHHHHHHHHHH		30.6322324799
526AcetylationSSLLQEAKTQAALVL
HHHHHHHHHHHHHHH		40.1823954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FTCD_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FTCD_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FTCD_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FTCD_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FTCD_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-519, AND MASSSPECTROMETRY.

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