FRPD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRPD2_HUMAN
• UniProt AC: Q68DX3
• Protein Name: FERM and PDZ domain-containing protein 2
• Gene Name: FRMPD2
• Organism: Homo sapiens (Human).
• Sequence Length: 1309
• Subcellular Localization: Cytoplasm . Basolateral cell membrane . Cell junction, tight junction . Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1.
• Protein Description: May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2)..
• Protein Sequence: MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPWSALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQMHVYSLGMTLYWSAGFHVPPHQPLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MQPLTKDAGMSL ---CCCCCCCCCCCH	33.30	20068231
11	Phosphorylation	LTKDAGMSLSSVTLA CCCCCCCCHHHHHHH	24.96	20068231
13	Phosphorylation	KDAGMSLSSVTLASA CCCCCCHHHHHHHHH	18.56	20068231
14	Phosphorylation	DAGMSLSSVTLASAL CCCCCHHHHHHHHHH	25.14	20068231
16	Phosphorylation	GMSLSSVTLASALQV CCCHHHHHHHHHHHH	20.68	20068231
19	Phosphorylation	LSSVTLASALQVRGE HHHHHHHHHHHHCCC	32.40	20068231
200	Phosphorylation	RVVEESSSVQQNRSY HHHHCCCCHHHHHHH	32.97	-
207	Phosphorylation	SVQQNRSYLLRKRLR CHHHHHHHHHHHHHC	13.40	-
217	Phosphorylation	RKRLRGTSSESPAAQ HHHHCCCCCCCCCCC	34.63	23532336
218	Phosphorylation	KRLRGTSSESPAAQA HHHCCCCCCCCCCCC	41.76	23532336
280	Phosphorylation	QQAGRRLSSGSVHSA HHHCCCCCCCCCCCC	30.73	27966365
281	Phosphorylation	QAGRRLSSGSVHSAA HHCCCCCCCCCCCCC	39.41	18077418
283	Phosphorylation	GRRLSSGSVHSAADS CCCCCCCCCCCCCCC	20.71	18077418
286	Phosphorylation	LSSGSVHSAADSSWP CCCCCCCCCCCCCCC	24.01	22210691
290	Phosphorylation	SVHSAADSSWPTTPS CCCCCCCCCCCCCHH	29.58	-
291	Phosphorylation	VHSAADSSWPTTPSQ CCCCCCCCCCCCHHH	37.31	22210691
297	Phosphorylation	SSWPTTPSQRGFLQR CCCCCCHHHCCCCHH	30.34	18077418
336	Ubiquitination	SVVTKKGKSYLALRD CEECCCCCEEEEHHH	44.82	-
417	Phosphorylation	WREQPQKTSMNTFTL HHHCCCCCCCCHHHH	28.14	29978859
418	Phosphorylation	REQPQKTSMNTFTLF HHCCCCCCCCHHHHH	19.64	29978859
421	Phosphorylation	PQKTSMNTFTLFLRI CCCCCCCHHHHHHHH	14.89	29978859
423	Phosphorylation	KTSMNTFTLFLRIKF CCCCCHHHHHHHHHH	17.98	29978859
429	Ubiquitination	FTLFLRIKFFVSHYG HHHHHHHHHHHHHHH	26.73	-
441	Phosphorylation	HYGLLQHSLTRHQFY HHHHHHHHHHHHHHH	20.62	-
575	Phosphorylation	CAKGVIVYEVKNNSR CCCCEEEEEEECCCE	12.13	-
606	Phosphorylation	YQKKFTITSSVTGKK EEEEEEEEECCCCCC	16.34	22210691
607	Phosphorylation	QKKFTITSSVTGKKH EEEEEEEECCCCCCE	20.96	22210691
608	Phosphorylation	KKFTITSSVTGKKHT EEEEEEECCCCCCEE	18.30	22210691
610	Phosphorylation	FTITSSVTGKKHTFV EEEEECCCCCCEEEE	45.27	-
618	Phosphorylation	GKKHTFVTDSAKTSK CCCEEEECCCHHHHH	21.75	28851738
620	Phosphorylation	KHTFVTDSAKTSKYL CEEEECCCHHHHHHH	23.46	28851738
670	Phosphorylation	SPAHQARSKPLIWIQ CHHHHHHCCCEEEEE	41.46	24719451
701	Phosphorylation	AAGGLLSTSMDNFNV HHCCCCCCCCCCCCC	28.21	25954137
702	Phosphorylation	AGGLLSTSMDNFNVD HCCCCCCCCCCCCCC	22.29	25954137
849	Phosphorylation	AVRMIQNSPDNIELI HHHHHHCCCCCEEEE	19.77	29978859
858	Phosphorylation	DNIELIISQSKGVGG CCEEEEEECCCCCCC	22.77	29978859
860	Phosphorylation	IELIISQSKGVGGNN EEEEEECCCCCCCCC	25.29	29978859
934	Phosphorylation	LPLKGAGSSCPPSPP CCCCCCCCCCCCCCC	28.38	-
939	Phosphorylation	AGSSCPPSPPEISAG CCCCCCCCCCCCCCC	37.92	-
1044	Phosphorylation	RSTQQCPSANDSMGD CCCCCCCCCCCCCCC	47.53	23663014
1092	Phosphorylation	NANGLGFSFVQMEKE CCCCCCCEEEEECHH	23.78	28851738
1227	Phosphorylation	GLGLRPESSQKAIRE CCCCCCHHHHHHHHH	40.53	-
1228	Phosphorylation	LGLRPESSQKAIREA CCCCCHHHHHHHHHH	33.76	-
1270	Phosphorylation	HQERDESTLATSLEK HHHCCHHHHHHHHHH	20.54	-
1299	Phosphorylation	LGRYSFSSPLTRLST HCCCCCCCCCHHHCC	23.17	24260401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRPD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRPD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRPD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PKN2_HUMAN	PKN2	physical	26186194
SYSC_HUMAN	SARS	physical	26186194
PKN2_HUMAN	PKN2	physical	28514442
SYSC_HUMAN	SARS	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.