UniProt ID | FRM4B_HUMAN | |
---|---|---|
UniProt AC | Q9Y2L6 | |
Protein Name | FERM domain-containing protein 4B | |
Gene Name | FRMD4B {ECO:0000312|HGNC:HGNC:24886} | |
Organism | Homo sapiens (Human). | |
Sequence Length | 1034 | |
Subcellular Localization | Cytoplasm, cytoskeleton . Cell junction, tight junction . Cell junction, adherens junction . Colocalized with PARD3 at adherens junction and tight junction. | |
Protein Description | Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization.. | |
Protein Sequence | MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRSSSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMPNLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYRSSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLRGWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQRLFWHEDSKPGTLV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
95 | Acetylation | VASHFNLKEKEYFGI HHHHCCCCCHHEEEE | 68.77 | 7667147 | |
146 | Phosphorylation | RFYIESISFLKDKTT HHHHHHHHCCCCCCE | 33.53 | 24719451 | |
263 | Acetylation | GVHYYAVKDKQGLPW CCEEEEEECCCCCCE | 51.54 | 19812241 | |
320 | Phosphorylation | VHDPRRISVSRRTFG ECCCCCEEEEEECCC | 16.54 | 24719451 | |
322 | Phosphorylation | DPRRISVSRRTFGQS CCCCEEEEEECCCCC | 14.84 | 23403867 | |
341 | Phosphorylation | QTWYANSSLIKSIWV EEEECCCHHHHHHHH | 33.64 | 24719451 | |
363 | Phosphorylation | FYLDRKQSKAKIPSA HHHCHHHHHCCCCCC | 37.30 | 24719451 | |
372 | Phosphorylation | AKIPSARSLDEIAMD CCCCCCCCHHHHCHH | 39.63 | 22777824 | |
529 | Phosphorylation | NEPDLCKTVKKKRKQ CCCCHHHHHHHHHHH | 36.24 | 28060719 | |
538 | Phosphorylation | KKKRKQDYTDAMKKL HHHHHHHHHHHHHHH | 12.20 | 29083192 | |
539 | Phosphorylation | KKRKQDYTDAMKKLQ HHHHHHHHHHHHHHH | 26.10 | 29083192 | |
550 | Phosphorylation | KKLQEIENAINEYRI HHHHHHHHHHHHHHH | 52.35 | 18088087 | |
554 | Phosphorylation | EIENAINEYRIRCGK HHHHHHHHHHHHCCC | 30.03 | 18088087 | |
561 | Acetylation | EYRIRCGKKPSQKAT HHHHHCCCCCCCCCE | 66.20 | 20167786 | |
568 | Phosphorylation | KKPSQKATVLPEDII CCCCCCCEECCHHHC | 29.61 | - | |
574 | Phosphorylation | ATVLPEDIIPSESSS CEECCHHHCCCCCCC | 4.81 | 18088087 | |
577 | Phosphorylation | LPEDIIPSESSSLSD CCHHHCCCCCCCCCC | 39.44 | 28270605 | |
579 | Phosphorylation | EDIIPSESSSLSDTT HHHCCCCCCCCCCCC | 29.57 | 28270605 | |
580 | Phosphorylation | DIIPSESSSLSDTTT HHCCCCCCCCCCCCC | 31.11 | 28270605 | |
581 | Phosphorylation | IIPSESSSLSDTTTY HCCCCCCCCCCCCCC | 40.97 | 28270605 | |
583 | Phosphorylation | PSESSSLSDTTTYDD CCCCCCCCCCCCCCC | 34.55 | 28270605 | |
585 | Phosphorylation | ESSSLSDTTTYDDPS CCCCCCCCCCCCCHH | 20.05 | 28270605 | |
586 | Phosphorylation | SSSLSDTTTYDDPSD CCCCCCCCCCCCHHH | 28.48 | 28270605 | |
587 | Phosphorylation | SSLSDTTTYDDPSDA CCCCCCCCCCCHHHC | 27.35 | 28270605 | |
588 | Phosphorylation | SLSDTTTYDDPSDAF CCCCCCCCCCHHHCC | 19.09 | 28270605 | |
592 | Phosphorylation | TTTYDDPSDAFTFPG CCCCCCHHHCCCCCC | 48.87 | 28270605 | |
596 | Phosphorylation | DDPSDAFTFPGQRSS CCHHHCCCCCCCCCC | 30.55 | 28270605 | |
602 | Phosphorylation | FTFPGQRSSSVPHSP CCCCCCCCCCCCCCC | 21.05 | 23403867 | |
603 | Phosphorylation | TFPGQRSSSVPHSPR CCCCCCCCCCCCCCC | 37.23 | 23403867 | |
604 | Phosphorylation | FPGQRSSSVPHSPRI CCCCCCCCCCCCCCC | 40.70 | 23403867 | |
608 | Phosphorylation | RSSSVPHSPRILPPK CCCCCCCCCCCCCCH | 15.14 | 28348404 | |
612 | Phosphorylation | VPHSPRILPPKSLGI CCCCCCCCCCHHHCC | 6.66 | 18088087 | |
627 | Phosphorylation | ERIHFRKSSINEQFV EEEEEECCHHHHHHC | 31.99 | 29255136 | |
628 | Phosphorylation | RIHFRKSSINEQFVD EEEEECCHHHHHHCC | 32.25 | 23401153 | |
636 | Phosphorylation | INEQFVDTRQSREML HHHHHCCHHHHHHHH | 25.88 | 23403867 | |
639 | Phosphorylation | QFVDTRQSREMLSTH HHCCHHHHHHHHHHC | 27.24 | 23403867 | |
644 | Phosphorylation | RQSREMLSTHSSPYK HHHHHHHHHCCCCCC | 23.82 | 23403867 | |
645 | Phosphorylation | QSREMLSTHSSPYKT HHHHHHHHCCCCCCC | 23.09 | 23403867 | |
647 | Phosphorylation | REMLSTHSSPYKTLE HHHHHHCCCCCCCCC | 32.85 | 23403867 | |
648 | Phosphorylation | EMLSTHSSPYKTLER HHHHHCCCCCCCCCC | 25.33 | 23403867 | |
650 | Phosphorylation | LSTHSSPYKTLERRP HHHCCCCCCCCCCCC | 20.67 | 23403867 | |
652 | Phosphorylation | THSSPYKTLERRPQG HCCCCCCCCCCCCCC | 28.18 | 22210691 | |
656 | Methylation | PYKTLERRPQGGRSM CCCCCCCCCCCCCCC | 20.65 | - | |
662 | Phosphorylation | RRPQGGRSMPTTPVL CCCCCCCCCCCCCEE | 32.18 | 22617229 | |
665 | Phosphorylation | QGGRSMPTTPVLTRN CCCCCCCCCCEECCC | 34.78 | 23403867 | |
666 | Phosphorylation | GGRSMPTTPVLTRNA CCCCCCCCCEECCCC | 12.91 | 22617229 | |
670 | Phosphorylation | MPTTPVLTRNAYSSS CCCCCEECCCCCCCC | 23.31 | 23403867 | |
671 | Methylation | PTTPVLTRNAYSSSH CCCCEECCCCCCCCC | 22.94 | - | |
674 | Phosphorylation | PVLTRNAYSSSHLEP CEECCCCCCCCCCCC | 16.79 | 23403867 | |
675 | Phosphorylation | VLTRNAYSSSHLEPE EECCCCCCCCCCCCC | 23.97 | 27794612 | |
676 | Phosphorylation | LTRNAYSSSHLEPES ECCCCCCCCCCCCCC | 14.76 | 23403867 | |
677 | Phosphorylation | TRNAYSSSHLEPESS CCCCCCCCCCCCCCC | 26.59 | 23403867 | |
683 | Phosphorylation | SSHLEPESSSQHCRQ CCCCCCCCCHHHHHH | 46.11 | 23403867 | |
684 | Phosphorylation | SHLEPESSSQHCRQR CCCCCCCCHHHHHHH | 32.15 | 23403867 | |
692 | Phosphorylation | SQHCRQRSGSLESQS HHHHHHHHCCHHHHH | 25.13 | 22617229 | |
694 | Phosphorylation | HCRQRSGSLESQSHL HHHHHHCCHHHHHHH | 30.15 | 22499768 | |
697 | Phosphorylation | QRSGSLESQSHLLSE HHHCCHHHHHHHHHH | 42.13 | 28450419 | |
699 | Phosphorylation | SGSLESQSHLLSEMD HCCHHHHHHHHHHCC | 25.94 | 28450419 | |
703 | Phosphorylation | ESQSHLLSEMDSDKP HHHHHHHHHCCCCCC | 36.92 | 29978859 | |
707 | Phosphorylation | HLLSEMDSDKPFFSL HHHHHCCCCCCCCCC | 46.34 | 28060719 | |
720 | Phosphorylation | SLSKSQRSSSTEILD CCCCCCCCCCCEECC | 22.47 | 27251275 | |
721 | Phosphorylation | LSKSQRSSSTEILDD CCCCCCCCCCEECCC | 43.39 | 27251275 | |
722 | Phosphorylation | SKSQRSSSTEILDDG CCCCCCCCCEECCCC | 31.16 | 27251275 | |
723 | Phosphorylation | KSQRSSSTEILDDGS CCCCCCCCEECCCCC | 29.06 | 27251275 | |
772 | Phosphorylation | RSKKQNVSTSNSGSM CCCCCCCCCCCCCCC | 33.40 | 23403867 | |
773 | Phosphorylation | SKKQNVSTSNSGSMP CCCCCCCCCCCCCCC | 27.87 | 23403867 | |
774 | Phosphorylation | KKQNVSTSNSGSMPN CCCCCCCCCCCCCCC | 22.84 | 23403867 | |
776 | Phosphorylation | QNVSTSNSGSMPNLA CCCCCCCCCCCCCHH | 31.82 | 23403867 | |
778 | Phosphorylation | VSTSNSGSMPNLAQK CCCCCCCCCCCHHHH | 30.78 | 25159151 | |
856 | Phosphorylation | RQRDYSRSFHEDEVD HHCCCCCCCCHHHCC | 25.64 | 28060719 | |
861 | Phosphorylation | SRSFHEDEVDRVPHN CCCCCHHHCCCCCCC | 43.25 | 18088087 | |
870 | Phosphorylation | DRVPHNPYATLRLPR CCCCCCCCCCCCCCH | 19.96 | 28060719 | |
872 | Phosphorylation | VPHNPYATLRLPRKA CCCCCCCCCCCCHHH | 13.43 | 28060719 | |
882 | Sumoylation | LPRKAAAKSEHITKN CCHHHHHCCHHHHHH | 52.21 | 28112733 | |
915 | Phosphorylation | GQKDQGHSPQTSFDS CCCCCCCCCCCCCCC | 26.06 | 25159151 | |
918 | Phosphorylation | DQGHSPQTSFDSDRG CCCCCCCCCCCCCCC | 34.44 | 28060719 | |
919 | Phosphorylation | QGHSPQTSFDSDRGS CCCCCCCCCCCCCCC | 23.08 | 28060719 | |
922 | Phosphorylation | SPQTSFDSDRGSQRC CCCCCCCCCCCCCCC | 27.48 | 28060719 | |
926 | Phosphorylation | SFDSDRGSQRCLGFA CCCCCCCCCCCCEEE | 18.49 | 28060719 | |
940 | Phosphorylation | AGLQVPCSPSSRASS ECEEEECCCCCCCCC | 23.03 | 29978859 | |
942 | Phosphorylation | LQVPCSPSSRASSYS EEEECCCCCCCCCCC | 19.03 | 29978859 | |
943 | Phosphorylation | QVPCSPSSRASSYSS EEECCCCCCCCCCCC | 34.94 | 29978859 | |
948 | Phosphorylation | PSSRASSYSSVSSTN CCCCCCCCCCCCCCC | 11.50 | 27642862 | |
973 | Phosphorylation | IGLSDYETPAHSSYT EECCCCCCCCCCCCC | 21.39 | - | |
987 | Phosphorylation | TSCYGNVYNPLPSPS CCCCCCCCCCCCCCC | 18.31 | 27080861 | |
992 | Phosphorylation | NVYNPLPSPSRQYTE CCCCCCCCCCCCCEE | 43.10 | 27080861 | |
994 | Phosphorylation | YNPLPSPSRQYTEIS CCCCCCCCCCCEEEE | 36.03 | 27080861 | |
1029 | Sumoylation | LFWHEDSKPGTLV-- HHEECCCCCCCCC-- | 60.84 | 28112733 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FRM4B_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FRM4B_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FRM4B_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
Oops, there are no PPI records of FRM4B_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604; SER-608; SER-628;SER-662; THR-666 AND SER-915, AND MASS SPECTROMETRY. |