FRM4B_HUMAN - dbPTM
FRM4B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FRM4B_HUMAN
UniProt AC Q9Y2L6
Protein Name FERM domain-containing protein 4B
Gene Name FRMD4B {ECO:0000312|HGNC:HGNC:24886}
Organism Homo sapiens (Human).
Sequence Length 1034
Subcellular Localization Cytoplasm, cytoskeleton . Cell junction, tight junction . Cell junction, adherens junction . Colocalized with PARD3 at adherens junction and tight junction.
Protein Description Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization..
Protein Sequence MASVFMCGVEDLLFSGSRFVWNLTVSTLRRWYTERLRACHQVLRTWCGLQDVYQMTEGRHCQVHLLDDRRLELLVQPKLLARELLDLVASHFNLKEKEYFGITFIDDTGQQNWLQLDHRVLDHDLPKKPGPTILHFAVRFYIESISFLKDKTTVELFFLNAKACVHKGQIEVESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTLQEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLETKSQFIMASNGSLISSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQELESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDAMKKLQEIENAINEYRIRCGKKPSQKATVLPEDIIPSESSSLSDTTTYDDPSDAFTFPGQRSSSVPHSPRILPPKSLGIERIHFRKSSINEQFVDTRQSREMLSTHSSPYKTLERRPQGGRSMPTTPVLTRNAYSSSHLEPESSSQHCRQRSGSLESQSHLLSEMDSDKPFFSLSKSQRSSSTEILDDGSSYTSQSSTEYYCVTPVTGPYYTTQTLDTRTRGRRRSKKQNVSTSNSGSMPNLAQKDSLRNGVYSKSQEPPSSSYYIAGYTPYAECDFYYSGGYVYENDTEGQYSVNPSYRSSAHYGYERQRDYSRSFHEDEVDRVPHNPYATLRLPRKAAAKSEHITKNIHKALVAEHLRGWYQRASGQKDQGHSPQTSFDSDRGSQRCLGFAGLQVPCSPSSRASSYSSVSSTNASGNWRTQLTIGLSDYETPAHSSYTSCYGNVYNPLPSPSRQYTEISQLDGTDGNQLEDNLESSEQRLFWHEDSKPGTLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
95AcetylationVASHFNLKEKEYFGI
HHHHCCCCCHHEEEE
68.777667147
146PhosphorylationRFYIESISFLKDKTT
HHHHHHHHCCCCCCE
33.5324719451
263AcetylationGVHYYAVKDKQGLPW
CCEEEEEECCCCCCE
51.5419812241
320PhosphorylationVHDPRRISVSRRTFG
ECCCCCEEEEEECCC
16.5424719451
322PhosphorylationDPRRISVSRRTFGQS
CCCCEEEEEECCCCC
14.8423403867
341PhosphorylationQTWYANSSLIKSIWV
EEEECCCHHHHHHHH
33.6424719451
363PhosphorylationFYLDRKQSKAKIPSA
HHHCHHHHHCCCCCC
37.3024719451
372PhosphorylationAKIPSARSLDEIAMD
CCCCCCCCHHHHCHH
39.6322777824
529PhosphorylationNEPDLCKTVKKKRKQ
CCCCHHHHHHHHHHH
36.2428060719
538PhosphorylationKKKRKQDYTDAMKKL
HHHHHHHHHHHHHHH
12.2029083192
539PhosphorylationKKRKQDYTDAMKKLQ
HHHHHHHHHHHHHHH
26.1029083192
550PhosphorylationKKLQEIENAINEYRI
HHHHHHHHHHHHHHH
52.3518088087
554PhosphorylationEIENAINEYRIRCGK
HHHHHHHHHHHHCCC
30.0318088087
561AcetylationEYRIRCGKKPSQKAT
HHHHHCCCCCCCCCE
66.2020167786
568PhosphorylationKKPSQKATVLPEDII
CCCCCCCEECCHHHC
29.61-
574PhosphorylationATVLPEDIIPSESSS
CEECCHHHCCCCCCC
4.8118088087
577PhosphorylationLPEDIIPSESSSLSD
CCHHHCCCCCCCCCC
39.4428270605
579PhosphorylationEDIIPSESSSLSDTT
HHHCCCCCCCCCCCC
29.5728270605
580PhosphorylationDIIPSESSSLSDTTT
HHCCCCCCCCCCCCC
31.1128270605
581PhosphorylationIIPSESSSLSDTTTY
HCCCCCCCCCCCCCC
40.9728270605
583PhosphorylationPSESSSLSDTTTYDD
CCCCCCCCCCCCCCC
34.5528270605
585PhosphorylationESSSLSDTTTYDDPS
CCCCCCCCCCCCCHH
20.0528270605
586PhosphorylationSSSLSDTTTYDDPSD
CCCCCCCCCCCCHHH
28.4828270605
587PhosphorylationSSLSDTTTYDDPSDA
CCCCCCCCCCCHHHC
27.3528270605
588PhosphorylationSLSDTTTYDDPSDAF
CCCCCCCCCCHHHCC
19.0928270605
592PhosphorylationTTTYDDPSDAFTFPG
CCCCCCHHHCCCCCC
48.8728270605
596PhosphorylationDDPSDAFTFPGQRSS
CCHHHCCCCCCCCCC
30.5528270605
602PhosphorylationFTFPGQRSSSVPHSP
CCCCCCCCCCCCCCC
21.0523403867
603PhosphorylationTFPGQRSSSVPHSPR
CCCCCCCCCCCCCCC
37.2323403867
604PhosphorylationFPGQRSSSVPHSPRI
CCCCCCCCCCCCCCC
40.7023403867
608PhosphorylationRSSSVPHSPRILPPK
CCCCCCCCCCCCCCH
15.1428348404
612PhosphorylationVPHSPRILPPKSLGI
CCCCCCCCCCHHHCC
6.6618088087
627PhosphorylationERIHFRKSSINEQFV
EEEEEECCHHHHHHC
31.9929255136
628PhosphorylationRIHFRKSSINEQFVD
EEEEECCHHHHHHCC
32.2523401153
636PhosphorylationINEQFVDTRQSREML
HHHHHCCHHHHHHHH
25.8823403867
639PhosphorylationQFVDTRQSREMLSTH
HHCCHHHHHHHHHHC
27.2423403867
644PhosphorylationRQSREMLSTHSSPYK
HHHHHHHHHCCCCCC
23.8223403867
645PhosphorylationQSREMLSTHSSPYKT
HHHHHHHHCCCCCCC
23.0923403867
647PhosphorylationREMLSTHSSPYKTLE
HHHHHHCCCCCCCCC
32.8523403867
648PhosphorylationEMLSTHSSPYKTLER
HHHHHCCCCCCCCCC
25.3323403867
650PhosphorylationLSTHSSPYKTLERRP
HHHCCCCCCCCCCCC
20.6723403867
652PhosphorylationTHSSPYKTLERRPQG
HCCCCCCCCCCCCCC
28.1822210691
656MethylationPYKTLERRPQGGRSM
CCCCCCCCCCCCCCC
20.65-
662PhosphorylationRRPQGGRSMPTTPVL
CCCCCCCCCCCCCEE
32.1822617229
665PhosphorylationQGGRSMPTTPVLTRN
CCCCCCCCCCEECCC
34.7823403867
666PhosphorylationGGRSMPTTPVLTRNA
CCCCCCCCCEECCCC
12.9122617229
670PhosphorylationMPTTPVLTRNAYSSS
CCCCCEECCCCCCCC
23.3123403867
671MethylationPTTPVLTRNAYSSSH
CCCCEECCCCCCCCC
22.94-
674PhosphorylationPVLTRNAYSSSHLEP
CEECCCCCCCCCCCC
16.7923403867
675PhosphorylationVLTRNAYSSSHLEPE
EECCCCCCCCCCCCC
23.9727794612
676PhosphorylationLTRNAYSSSHLEPES
ECCCCCCCCCCCCCC
14.7623403867
677PhosphorylationTRNAYSSSHLEPESS
CCCCCCCCCCCCCCC
26.5923403867
683PhosphorylationSSHLEPESSSQHCRQ
CCCCCCCCCHHHHHH
46.1123403867
684PhosphorylationSHLEPESSSQHCRQR
CCCCCCCCHHHHHHH
32.1523403867
692PhosphorylationSQHCRQRSGSLESQS
HHHHHHHHCCHHHHH
25.1322617229
694PhosphorylationHCRQRSGSLESQSHL
HHHHHHCCHHHHHHH
30.1522499768
697PhosphorylationQRSGSLESQSHLLSE
HHHCCHHHHHHHHHH
42.1328450419
699PhosphorylationSGSLESQSHLLSEMD
HCCHHHHHHHHHHCC
25.9428450419
703PhosphorylationESQSHLLSEMDSDKP
HHHHHHHHHCCCCCC
36.9229978859
707PhosphorylationHLLSEMDSDKPFFSL
HHHHHCCCCCCCCCC
46.3428060719
720PhosphorylationSLSKSQRSSSTEILD
CCCCCCCCCCCEECC
22.4727251275
721PhosphorylationLSKSQRSSSTEILDD
CCCCCCCCCCEECCC
43.3927251275
722PhosphorylationSKSQRSSSTEILDDG
CCCCCCCCCEECCCC
31.1627251275
723PhosphorylationKSQRSSSTEILDDGS
CCCCCCCCEECCCCC
29.0627251275
772PhosphorylationRSKKQNVSTSNSGSM
CCCCCCCCCCCCCCC
33.4023403867
773PhosphorylationSKKQNVSTSNSGSMP
CCCCCCCCCCCCCCC
27.8723403867
774PhosphorylationKKQNVSTSNSGSMPN
CCCCCCCCCCCCCCC
22.8423403867
776PhosphorylationQNVSTSNSGSMPNLA
CCCCCCCCCCCCCHH
31.8223403867
778PhosphorylationVSTSNSGSMPNLAQK
CCCCCCCCCCCHHHH
30.7825159151
856PhosphorylationRQRDYSRSFHEDEVD
HHCCCCCCCCHHHCC
25.6428060719
861PhosphorylationSRSFHEDEVDRVPHN
CCCCCHHHCCCCCCC
43.2518088087
870PhosphorylationDRVPHNPYATLRLPR
CCCCCCCCCCCCCCH
19.9628060719
872PhosphorylationVPHNPYATLRLPRKA
CCCCCCCCCCCCHHH
13.4328060719
882SumoylationLPRKAAAKSEHITKN
CCHHHHHCCHHHHHH
52.2128112733
915PhosphorylationGQKDQGHSPQTSFDS
CCCCCCCCCCCCCCC
26.0625159151
918PhosphorylationDQGHSPQTSFDSDRG
CCCCCCCCCCCCCCC
34.4428060719
919PhosphorylationQGHSPQTSFDSDRGS
CCCCCCCCCCCCCCC
23.0828060719
922PhosphorylationSPQTSFDSDRGSQRC
CCCCCCCCCCCCCCC
27.4828060719
926PhosphorylationSFDSDRGSQRCLGFA
CCCCCCCCCCCCEEE
18.4928060719
940PhosphorylationAGLQVPCSPSSRASS
ECEEEECCCCCCCCC
23.0329978859
942PhosphorylationLQVPCSPSSRASSYS
EEEECCCCCCCCCCC
19.0329978859
943PhosphorylationQVPCSPSSRASSYSS
EEECCCCCCCCCCCC
34.9429978859
948PhosphorylationPSSRASSYSSVSSTN
CCCCCCCCCCCCCCC
11.5027642862
973PhosphorylationIGLSDYETPAHSSYT
EECCCCCCCCCCCCC
21.39-
987PhosphorylationTSCYGNVYNPLPSPS
CCCCCCCCCCCCCCC
18.3127080861
992PhosphorylationNVYNPLPSPSRQYTE
CCCCCCCCCCCCCEE
43.1027080861
994PhosphorylationYNPLPSPSRQYTEIS
CCCCCCCCCCCEEEE
36.0327080861
1029SumoylationLFWHEDSKPGTLV--
HHEECCCCCCCCC--
60.8428112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FRM4B_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FRM4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FRM4B_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FRM4B_HUMAN !!

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FRM4B_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604; SER-608; SER-628;SER-662; THR-666 AND SER-915, AND MASS SPECTROMETRY.

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