FRITZ_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FRITZ_HUMAN
• UniProt AC: O95876
• Protein Name: WD repeat-containing and planar cell polarity effector protein fritz homolog
• Gene Name: WDPCP
• Organism: Homo sapiens (Human).
• Sequence Length: 746
• Subcellular Localization: Cell membrane . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, cilium basal body .
• Protein Description: Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity)..
• Protein Sequence: MRREFCWDAYSKAAGSRASSPLPRQDRDSFCHQMSFCLTELHLWSLKNTLHIADRDIGIYQYYDKKDPPATEHGNLEKKQKLAESRDYPWTLKNRRPEKLRDSLKELEELMQNSRCVLSKWKNKYVCQLLFGSGVLVSLSLSGPQLEKVVIDRSLVGKLISDTISDALLTDSFIILSFLAQNKLCFIQFTKKMESSDVNKRLEKLSALDYKIFYYEIPGPINKTTERHLAINCVHDRVVCWWPLVNDDAWPWAPISSEKDRANLLLLGYAQGRLEVLSSVRTEWDPLDVRFGTKQPYQVFTVEHSVSVDKEPMADSCIYECIRNKIQCVSVTRIPLKSKAISCCRNVTEDKLILGCEDSSLILYETHRRVTLLAQTELLPSLISCHPSGAILLVGSNQGELQIFDMALSPINIQLLAEDRLPRETLQFSKLFDASSSLVQMQWIAPQVVSQKGEGSDIYDLLFLRFERGPLGVLLFKLGVFTRGQLGLIDIIFQYIHCDEIYEAINILSSMNWDTLGHQCFISMSAIVNHLLRQKLTPEREAQLETSLGTFYAPTRPLLDSTILEYRDQISKYARRFFHHLLRYQRFEKAFLLAVDVGARDLFMDIHYLALDKGELALAEVARKRASDIDAESITSGVELLGPLDRGDMLNEAFIGLSLAPQGEDSFPDNLPPSCPTHRHILQQRILNGSSNRQIIDRRNELEKDICSGFLMTNTCNAEDGELREDGREQEIRDGGSLKMIHFGLV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	FCWDAYSKAAGSRAS HHHHHHHHHCCCCCC	29.58	-
19	Phosphorylation	KAAGSRASSPLPRQD HHCCCCCCCCCCCCC	31.23	27251275
20	Phosphorylation	AAGSRASSPLPRQDR HCCCCCCCCCCCCCH	29.48	24719451
85	Phosphorylation	KKQKLAESRDYPWTL HHHHHHHHCCCCCHH	25.50	25463755
88	Phosphorylation	KLAESRDYPWTLKNR HHHHHCCCCCHHCCC	10.27	26074081
91	Phosphorylation	ESRDYPWTLKNRRPE HHCCCCCHHCCCCHH	24.29	26074081
196	Phosphorylation	FTKKMESSDVNKRLE CCCCCCCCHHHHHHH	32.07	-
210	Phosphorylation	EKLSALDYKIFYYEI HHHHHCCEEEEEEEC	13.56	-
278	Phosphorylation	QGRLEVLSSVRTEWD HHHHHHHHHCCCCCC	31.78	24719451
279	Phosphorylation	GRLEVLSSVRTEWDP HHHHHHHHCCCCCCC	16.09	26852163
325	Ubiquitination	IYECIRNKIQCVSVT HHHHHHHCCCEEEEE	25.06	-
608 (in isoform 2)	Phosphorylation	-	8.26	22210691
611 (in isoform 2)	Phosphorylation	-	6.89	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FRITZ_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FRITZ_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FRITZ_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FRITZ_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.