dbPTM

FRIH_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FRIH_RAT
UniProt AC	P19132
Protein Name	Ferritin heavy chain
Gene Name	Fth1
Organism	Rattus norvegicus (Rat).
Sequence Length	182
Subcellular Localization
Protein Description	Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity)..
Protein Sequence	MTTASPSQVRQNYHQDSEAAINRQINLELYASYVYLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQDIKKPDRDDWESGLNAMRCALHLEKSVNQSLLELHKLATDKNDPHLCDFIETHYLNEQVKSIKELGDHVTNLRKMGAPESGMAEYLFDKHTLGHGDES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTTASPSQ -------CCCCCHHH	7.29	-
2	Acetylation	------MTTASPSQV ------CCCCCHHHH	30.94	-
2	Phosphorylation	------MTTASPSQV ------CCCCCHHHH	30.94	27097102
3	Phosphorylation	-----MTTASPSQVR -----CCCCCHHHHH	24.68	27097102
5	Phosphorylation	---MTTASPSQVRQN ---CCCCCHHHHHHH	24.00	27097102
7	Phosphorylation	-MTTASPSQVRQNYH -CCCCCHHHHHHHHC	38.52	27097102
54	Acetylation	VALKNFAKYFLHQSH HHHHHHHHHHHHCCH	32.19	22902405
110	Phosphorylation	CALHLEKSVNQSLLE HHHHHHHHHHHHHHH	19.54	25575281
114	Phosphorylation	LEKSVNQSLLELHKL HHHHHHHHHHHHHHH	29.71	28689409

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FRIH_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FRIH_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FRIH_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FRIH_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FRIH_RAT

Related Literatures of Post-Translational Modification