FREM1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FREM1_HUMAN
• UniProt AC: Q5H8C1
• Protein Name: FRAS1-related extracellular matrix protein 1 {ECO:0000305}
• Gene Name: FREM1 {ECO:0000312|HGNC:HGNC:23399}
• Organism: Homo sapiens (Human).
• Sequence Length: 2179
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Localizes at the basement membrane zone of embryonic epidermis and hair follicles..
• Protein Description: Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development..
• Protein Sequence: MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSGDDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDEDTVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLRFDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPRGDQPHSFFPESQLRAKLKCPGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPPSPNIDYISIQLDLTDTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTWKDLSDMQIAYQPPNSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEGQSRAITWEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGVVRYHHDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTEHILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMNCSEGGEVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSKGGQCHPSYSSNQSKHSTWEKGIWHLLPPGSSSSTTSGSFHLERRPLPSSMQLAVIRGDTLRGFDSTDLSQRKLRTRGNGKTVRPSSVYRNGTDIIYNYHGIVSLKLEDDSFPTHKRKAKVSIISQPQKTIKVAELPQADKVESTTDSHFPRQDQLPSFPKNCTLELKGLFHFEEGIQKLYQCNGIAWKAWSPQTKDVEDKSCPAGWHQHSGYCHILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMRWLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPVAFTNGRRGPSQRSKLGKSCVLVQRQGKWQTKDCRRAKPHNYVCSRKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	KGHSAFLSGDDLKFA CCCCEEECCCCCCCC	33.45	-
112	Phosphorylation	KLRLYRFTERDTFIE EEEEEECCCCCCHHH	22.55	24275569
163	Phosphorylation	KNLLRFDYDRMASLE HCCCCCCHHHHHCCE	11.61	-
204 (in isoform 4)	Phosphorylation	-	31.44	29116813
222	Phosphorylation	KLKCPGGSCTPGLKK CCCCCCCCCCCCHHH	22.26	24719451
335	N-linked_Glycosylation	PKPLLVFNITKAPLQ CCCEEEEEECCCCCC	33.27	UniProtKB CARBOHYD
405	Phosphorylation	APMTVHISIRTADTN CCEEEEEEEEECCCC	7.37	24719451
560	N-linked_Glycosylation	SDDYIFFNITKPPQA CCCEEEEEECCCCCC	30.21	UniProtKB CARBOHYD
622	N-linked_Glycosylation	WDSHEPPNLSVPQVA ECCCCCCCCCCCCEE	56.51	UniProtKB CARBOHYD
714	Phosphorylation	PKVVKNPTALELRSF CCCCCCCCHHHHHHH	53.95	25002506
815	Phosphorylation	KLDNIDLSLRELPLH CHHCCCEEECCCCCC	22.95	24719451
950	Phosphorylation	GVTVDQFSQRDVISE CCCHHHCCCHHHHCC	20.76	-
1014	N-linked_Glycosylation	SFPVYDLNITVYPVD ECCEEEEEEEEEECC	25.61	UniProtKB CARBOHYD
1223	Phosphorylation	QKHAPVHSFSMELLK CCCCCCCHHHHHHHH	21.17	-
1306	Phosphorylation	LSAIDEDSPREKIYY HHHCCCCCCHHHEEE	24.65	-
1312	Phosphorylation	DSPREKIYYVFERLP CCCHHHEEEEEECCC	12.49	-
1353	Phosphorylation	VDLNLLRYTHTGAMD HCHHHEEEECCCCCC	11.66	24043423
1354	Phosphorylation	DLNLLRYTHTGAMDS CHHHEEEECCCCCCC	13.41	24043423
1356	Phosphorylation	NLLRYTHTGAMDSQN HHEEEECCCCCCCCC	20.88	24043423
1361	Phosphorylation	THTGAMDSQNQDSFT ECCCCCCCCCCCCEE	20.25	24043423
1366	Phosphorylation	MDSQNQDSFTFYLWD CCCCCCCCEEEEEEC	19.20	24043423
1368	Phosphorylation	SQNQDSFTFYLWDGN CCCCCCEEEEEECCC	18.47	24043423
1370	Phosphorylation	NQDSFTFYLWDGNNR CCCCEEEEEECCCCC	12.11	24043423
1439	Phosphorylation	VITSPPRYGQIEYVH EEECCCCCCCEEEEE	21.11	24043423
1444	Phosphorylation	PRYGQIEYVHYPGVP CCCCCEEEEECCCCC	8.31	24043423
1447	Phosphorylation	GQIEYVHYPGVPITN CCEEEEECCCCCCCC	7.52	24043423
1453	Phosphorylation	HYPGVPITNFSQMDV ECCCCCCCCCHHCCC	24.92	24043423
1456	Phosphorylation	GVPITNFSQMDVVGQ CCCCCCCHHCCCCCC	27.02	24043423
1464	Phosphorylation	QMDVVGQTVCYVHKS HCCCCCCEEEEEECC	13.45	24043423
1467	Phosphorylation	VVGQTVCYVHKSKVT CCCCEEEEEECCEEE	10.97	24043423
1566	N-linked_Glycosylation	GTGLLQHNFTQQDVD CCCCCCCCCCCCCCC	28.80	UniProtKB CARBOHYD
1631	Phosphorylation	DKTAPRITLLHSPSQ CCCCCEEEEECCHHH	25.25	25921289
1635	Phosphorylation	PRITLLHSPSQVGLL CEEEEECCHHHHCCC	26.64	25921289
1768	Phosphorylation	LEIIRRGYSMDSAFV HHHHHCCCCCCCCEE	10.06	-
1769	Phosphorylation	EIIRRGYSMDSAFVG HHHHCCCCCCCCEEC	20.95	29116813
1772	Phosphorylation	RRGYSMDSAFVGIKV HCCCCCCCCEECEEH	18.24	29116813
1783	Phosphorylation	GIKVNQVSAAVGKDF CEEHHEEEECCCCCE	10.76	29116813
1791	Phosphorylation	AAVGKDFTVIPSKLI ECCCCCEEEEEHHHE	27.88	25954137
1795	Phosphorylation	KDFTVIPSKLIQFDP CCEEEEEHHHEECCC	29.04	25954137
1858	Phosphorylation	KGGQCHPSYSSNQSK CCCCCCCCCCCCCCC	17.62	-
1859	Phosphorylation	GGQCHPSYSSNQSKH CCCCCCCCCCCCCCC	22.14	-
1900	Phosphorylation	ERRPLPSSMQLAVIR EECCCCCCCEEEEEE	14.49	-
1910	Phosphorylation	LAVIRGDTLRGFDST EEEEECCCCCCCCCC	22.60	-
1943	Phosphorylation	SSVYRNGTDIIYNYH HHHEECCCEEEEEEC	27.81	-
1954	Phosphorylation	YNYHGIVSLKLEDDS EEECCEEEEEECCCC	20.19	-
1964	Phosphorylation	LEDDSFPTHKRKAKV ECCCCCCCCCCCEEE	37.71	-
1970	Ubiquitination	PTHKRKAKVSIISQP CCCCCCEEEEEECCC	39.28	-
1995	O-linked_Glycosylation	QADKVESTTDSHFPR CCCCCCCCCCCCCCC	22.55	OGP
1996	O-linked_Glycosylation	ADKVESTTDSHFPRQ CCCCCCCCCCCCCCH	44.79	OGP
2142	Phosphorylation	TNGRRGPSQRSKLGK CCCCCCHHHHHHCCC	40.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FREM1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FREM1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FREM1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FREM1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.