FOXP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXP2_MOUSE
• UniProt AC: P58463
• Protein Name: Forkhead box protein P2
• Gene Name: Foxp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 714
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels..
• Protein Sequence: MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSEKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSTTSKASPPITHHSIVNGQSSVLNARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	Phosphorylation	LLLQQQTSGLKSPKS HHHHHHHHCCCCCCC	37.48	24759943
75	Phosphorylation	QQTSGLKSPKSSEKQ HHHHCCCCCCCCCCC	42.47	24759943
307	Phosphorylation	SSTTSKASPPITHHS CCCCCCCCCCCEEEE	34.64	27841257
406	Phosphorylation	ERLQAMMTHLHMRPS HHHHHHHHHHHCCCC	14.27	26824392
590	Phosphorylation	RSQKITGSPTLVKNI HHCCCCCCCCCCCCC	13.18	24759943
592	Phosphorylation	QKITGSPTLVKNIPT CCCCCCCCCCCCCCC	45.97	26060331
673	Sumoylation	HIHSIHVKEEPVIAE CEEEEEECCCCEEEC	42.04	-
687	Phosphorylation	EDEDCPMSLVTTANH CCCCCCCEEEECCCC	12.58	-
710	Phosphorylation	EIEEEPLSEDLE--- HHCCCCCCCCCC---	39.52	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOXP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P66B_HUMAN	GATAD2B	physical	20185820

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.