FOXK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOXK1_MOUSE
• UniProt AC: P42128
• Protein Name: Forkhead box protein K1
• Gene Name: Foxk1
• Organism: Mus musculus (Mouse).
• Sequence Length: 719
• Subcellular Localization: Nucleus . Cytoplasm . Accumulates in the nucleus upon viral infection.
• Protein Description: Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. [PubMed: 8007964 Important regulatory factor of the myogenic progenitor cell population]
• Protein Sequence: MAEVGEDSGARALLALRSAPCSPVLCAAAAAAAFPATTSPPPPAQPPPGPPALPAEPGPGPVPSTVATATTTAPALVAAAAASVRQSPGPALARLEGREFEFLMRQPSVTIGRNSSQGSVDLSMGLSSFISRRHLQLSFQEPHFYLRCLGKNGVFVDGAFQRRGAPALQLPQQCTFRFPSTAIKIQFTSLYHKEEAPASPLRPLYPQISPLKIHIPEPDLRSLVSPIPSPTGTISVPNSCPASPRGAGSSSYRFVQNVTSDLQLAAEFAAKAASEQQADASGGDSPKDESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASEAKLVEQAFRKRRQRGVSCFRTPFGPLSSRSAPASPTHPGLMSPRSSGLQTPECLSREGSPIPHDPDLGSKLASVPEYRYSQSAPGSPVSAQPVIMAVPPRPSNLVAKPVAYMPASIVTSQQPSGHAIHVVQQAPTVTMVRVVTTSANSANGYILASQGSTGTSHDTAGTAVLDLGNEARGLEEKPTIAFATIPAASRVIQTVASQMAPGVPGHTVTILQPATPVTIGQHHLPVRAVTQNGKHAVPTNSLTGNAYALSSPLQLLAAQASSSTPVVITRVCEVGPEEPAAAVSVAANAAPTPAASTTTSASSSGEPEVKRSRVEEPGGTATTQPTAMAATGPQGPGTGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEVGEDSG ------CCCCCCCHH	21.85	-
87	Phosphorylation	AAASVRQSPGPALAR HHHHHHCCCCCHHHH	22.66	26824392
108	Phosphorylation	EFLMRQPSVTIGRNS EEEECCCCEEECCCC	24.45	29514104
110	Phosphorylation	LMRQPSVTIGRNSSQ EECCCCEEECCCCCC	23.27	28059163
147	Methylation	QEPHFYLRCLGKNGV CCCCEEEEEECCCCE	11.39	24129315
177	Dimethylation	LPQQCTFRFPSTAIK CCCCCEEECCCCEEE	25.14	-
177	Methylation	LPQQCTFRFPSTAIK CCCCCEEECCCCEEE	25.14	-
188	Phosphorylation	TAIKIQFTSLYHKEE CEEEEEEEECCCCCC	11.05	21183079
189	Phosphorylation	AIKIQFTSLYHKEEA EEEEEEEECCCCCCC	28.37	23984901
191	Ubiquitination	KIQFTSLYHKEEAPA EEEEEECCCCCCCCC	15.60	27667366
191	Phosphorylation	KIQFTSLYHKEEAPA EEEEEECCCCCCCCC	15.60	25266776
199	Phosphorylation	HKEEAPASPLRPLYP CCCCCCCCCCCCCCC	24.33	27087446
205	Phosphorylation	ASPLRPLYPQISPLK CCCCCCCCCCCCCCE	8.86	25168779
209	Phosphorylation	RPLYPQISPLKIHIP CCCCCCCCCCEEECC	20.94	25521595
222	Phosphorylation	IPEPDLRSLVSPIPS CCCCCHHHHCCCCCC	40.18	23527152
225	Phosphorylation	PDLRSLVSPIPSPTG CCHHHHCCCCCCCCC	23.54	26824392
229	Phosphorylation	SLVSPIPSPTGTISV HHCCCCCCCCCCEEC	35.49	26824392
231	Phosphorylation	VSPIPSPTGTISVPN CCCCCCCCCCEECCC	51.82	22942356
233	Phosphorylation	PIPSPTGTISVPNSC CCCCCCCCEECCCCC	16.74	22942356
235	Phosphorylation	PSPTGTISVPNSCPA CCCCCCEECCCCCCC	31.21	22942356
239	Phosphorylation	GTISVPNSCPASPRG CCEECCCCCCCCCCC	18.53	21082442
243	Phosphorylation	VPNSCPASPRGAGSS CCCCCCCCCCCCCCC	10.56	23527152
249	Phosphorylation	ASPRGAGSSSYRFVQ CCCCCCCCCCEECCC	18.64	23984901
250	Phosphorylation	SPRGAGSSSYRFVQN CCCCCCCCCEECCCH	30.39	23984901
251	Phosphorylation	PRGAGSSSYRFVQNV CCCCCCCCEECCCHH	23.25	23984901
252	Phosphorylation	RGAGSSSYRFVQNVT CCCCCCCEECCCHHC	15.26	23984901
274	Phosphorylation	EFAAKAASEQQADAS HHHHHHHHHHHHHCC	40.58	26160508
281	Phosphorylation	SEQQADASGGDSPKD HHHHHHCCCCCCCCC	43.80	25521595
285	Phosphorylation	ADASGGDSPKDESKP HHCCCCCCCCCCCCC	36.80	25521595
290	Phosphorylation	GDSPKDESKPPYSYA CCCCCCCCCCCCCHH	61.67	26160508
294	Phosphorylation	KDESKPPYSYAQLIV CCCCCCCCCHHHHHH	23.88	21659605
295	Phosphorylation	DESKPPYSYAQLIVQ CCCCCCCCHHHHHHH	21.55	26160508
296	Phosphorylation	ESKPPYSYAQLIVQA CCCCCCCHHHHHHHH	7.79	26160508
305	Phosphorylation	QLIVQAISSAQDRQL HHHHHHHHCHHHHEE	23.72	23984901
306	Phosphorylation	LIVQAISSAQDRQLT HHHHHHHCHHHHEEE	24.68	23984901
344	Phosphorylation	NSIRHNLSLNRYFIK HHHHHCCEECCEEEE	28.99	19854140
361	Ubiquitination	RSQEEPGKGSFWRID CCCCCCCCCCCEECC	63.20	27667366
361	Acetylation	RSQEEPGKGSFWRID CCCCCCCCCCCEECC	63.20	23806337
363	Phosphorylation	QEEPGKGSFWRIDPA CCCCCCCCCEECCHH	25.73	23684622
374	Ubiquitination	IDPASEAKLVEQAFR CCHHHHHHHHHHHHH	49.35	22790023
389	Phosphorylation	KRRQRGVSCFRTPFG HHHHHCCCCCCCCCC	15.46	29514104
393	Phosphorylation	RGVSCFRTPFGPLSS HCCCCCCCCCCCCCC	11.61	26643407
399	Phosphorylation	RTPFGPLSSRSAPAS CCCCCCCCCCCCCCC	27.17	25266776
400	Phosphorylation	TPFGPLSSRSAPASP CCCCCCCCCCCCCCC	37.63	25266776
402	Phosphorylation	FGPLSSRSAPASPTH CCCCCCCCCCCCCCC	40.32	27087446
406	Phosphorylation	SSRSAPASPTHPGLM CCCCCCCCCCCCCCC	29.31	27087446
408	Phosphorylation	RSAPASPTHPGLMSP CCCCCCCCCCCCCCC	37.90	25521595
414	Phosphorylation	PTHPGLMSPRSSGLQ CCCCCCCCCCCCCCC	23.39	27087446
417	Phosphorylation	PGLMSPRSSGLQTPE CCCCCCCCCCCCCHH	31.94	25619855
418	Phosphorylation	GLMSPRSSGLQTPEC CCCCCCCCCCCCHHH	44.81	21082442
422	Phosphorylation	PRSSGLQTPECLSRE CCCCCCCCHHHHCCC	26.54	25521595
427	Phosphorylation	LQTPECLSREGSPIP CCCHHHHCCCCCCCC	39.69	25521595
431	Phosphorylation	ECLSREGSPIPHDPD HHHCCCCCCCCCCCC	18.20	27087446
441	Phosphorylation	PHDPDLGSKLASVPE CCCCCHHHHHCCCCC	31.62	25619855
445	Phosphorylation	DLGSKLASVPEYRYS CHHHHHCCCCCCCCC	48.95	26643407
449	Phosphorylation	KLASVPEYRYSQSAP HHCCCCCCCCCCCCC	14.58	26643407
451	Phosphorylation	ASVPEYRYSQSAPGS CCCCCCCCCCCCCCC	15.34	26643407
452	Phosphorylation	SVPEYRYSQSAPGSP CCCCCCCCCCCCCCC	14.52	25266776
454	Phosphorylation	PEYRYSQSAPGSPVS CCCCCCCCCCCCCCC	30.41	25266776
458	Phosphorylation	YSQSAPGSPVSAQPV CCCCCCCCCCCCCCE	22.52	25266776
461	Phosphorylation	SAPGSPVSAQPVIMA CCCCCCCCCCCEEEE	25.27	25293948
618	Phosphorylation	NGKHAVPTNSLTGNA CCCCCCCCCCCCCCE	30.73	23984901
620	Phosphorylation	KHAVPTNSLTGNAYA CCCCCCCCCCCCEEH	29.77	23984901
622	Phosphorylation	AVPTNSLTGNAYALS CCCCCCCCCCEEHHC	28.36	23984901
626	Phosphorylation	NSLTGNAYALSSPLQ CCCCCCEEHHCCHHH	16.45	23984901
629	Phosphorylation	TGNAYALSSPLQLLA CCCEEHHCCHHHHHH	23.03	23984901
630	Phosphorylation	GNAYALSSPLQLLAA CCEEHHCCHHHHHHH	30.40	23984901
640	Phosphorylation	QLLAAQASSSTPVVI HHHHHHCCCCCCEEE	16.85	23984901
641	Phosphorylation	LLAAQASSSTPVVIT HHHHHCCCCCCEEEE	41.04	23984901
642	Phosphorylation	LAAQASSSTPVVITR HHHHCCCCCCEEEEE	33.95	23984901
643	Phosphorylation	AAQASSSTPVVITRV HHHCCCCCCEEEEEE	23.27	23984901
663	O-linked_Glycosylation	EEPAAAVSVAANAAP CCCCHHHHHHHCCCC	11.00	22517741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
427	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
431	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOXK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOXK1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FOXK1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199, AND MASSSPECTROMETRY.
PubMed: 19367708

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-199; SER-402; SER-406;SER-414 AND THR-422, AND MASS SPECTROMETRY.
PubMed: 17242355