FOSB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOSB_MOUSE
• UniProt AC: P13346
• Protein Name: Protein fosB
• Gene Name: Fosb
• Organism: Mus musculus (Mouse).
• Sequence Length: 338
• Subcellular Localization: Nucleus.
• Protein Description: FosB interacts with Jun proteins enhancing their DNA binding activity..
• Protein Sequence: MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGLSAYSTGGASGSGGPSTSTTTSGPVSARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGAQRTSGSEQPSDPLNSPSLLAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	SAESQYLSSVDSFGS CHHHHHHHCCCCCCC	24.31	22817900
149	Phosphorylation	PRRPREETLTPEEEE CCCCCHHCCCHHHHH	31.04	-
180	Phosphorylation	RNRRRELTDRLQAET HHHHHHHHHHHHHHH	17.83	-
332	Phosphorylation	QPSDPLNSPSLLAL- CCCCCCCCCHHHCC-	24.45	26745281
334	Phosphorylation	SDPLNSPSLLAL--- CCCCCCCHHHCC---	35.52	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
27	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
27	S	Phosphorylation	Kinase	CAMK2A	P11798	PSP
149	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP
149	T	Phosphorylation	Kinase	CAMK2A	P11798	PSP
180	T	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOSB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOSB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTA1_MOUSE	Mta1	physical	21258411
HDAC2_MOUSE	Hdac2	physical	21258411

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.