FOG2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOG2_MOUSE
• UniProt AC: Q8CCH7
• Protein Name: Zinc finger protein ZFPM2
• Gene Name: Zfpm2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1151
• Subcellular Localization: Nucleus .
• Protein Description: Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2..
• Protein Sequence: MSRRKQSKPRQIKRPLEDAIDDEEEECPVEEAEVISKGDFPLEGSFPAGFEPENLSCEDVEFFCNKGDDEGIQEPAESDGDSHSDKPGQPGVETDDWDGPGELEVFQRDGERKIQSRQQLPVGTTWGPFAGKMDLNNNSLKTKAQVPMVLTAGPKWLLDVTWQGVEDSKNNCIVYSKGGQLWCTTTKAISEGEELVAFVVDFDSRLQAASHMTLTEGMYPARLLDSIQLLPQQAAMASILPTAIVNKDIFPCKSCGIWYRSERNLQAHLMYYCSGRQREAAPVSEENEDNSHQVSSLCPFPQCTKSFSNARALEMHLNSHSGVKMEEFLPPGASLKCTVCSYTADSVINFHQHLFSHLTQAAFRCNHCHFGFQTQRELLQHQELHVPSGKLPRESDMEHSPSGTEDSLQPATDLLARSDLSQSQKAMPTKDASSDTELDKCEKKTQLFLTNQRPEIQPAANKQNFSYTKIKSEPSSPRLASSPVQPNIGPSFPVGPFLSQFAFPQDITMVPQASEILAKMSELVHRRLRHGSSSYPPVIYSPLMPKGATCFECNITFNNLDNYLVHKKHYCSSRWQQMAKSPEFPSVSEKMPEAVSPNTGQTSINLLNPAAHSSDPENPLLQTSCINSSTVLDLIGPNGKGHEKDFSTQVKKLPTSNSSDDKINGKPVDVKNPSGPLVDGESDPNKTTCEACNITFSRHETYMVHKQYYCATRHDPPLKRSASNKVPAMQRTMRTRKRRKMYEMCLPEQEQRPPLVQQRFLDVANLSNPCSSTQEPTEGLGECYHPRCDIFPGIVSKHLETSLAMNKCVPVPKCDTTHSNVSCLEMDVPIDLSKKCLSQSERTTASPKRLLDYHECTVCKISFNKVENYLAHKQNFCPVTAHQRNDLGQLDGKVFPNPESERSSPEVSFERNMIKCEKNGNPKQPSPNGNLFSSHLATLQGLKVFSEAAQLIATKEENKHLFLPQCLYPGAIKKTKGADQLSPYYGIKPSDYIASSLVIHNTDVEQSTNTENESPKGQASSNGCAVPKKDSLPLLPKNRGMVIVNGGLKQDERPTANPQQENISQNTQHEDGHKSPSWISENPLAANENVSPGIPCAEEQLSSIAKGVNGASQAPSSGKYCRLCDIQFNNLSNFITHKKFYCSSHAAEHVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	GIQEPAESDGDSHSD CCCCCCCCCCCCCCC	49.34	29550500
82	Phosphorylation	PAESDGDSHSDKPGQ CCCCCCCCCCCCCCC	30.35	29550500
84	Phosphorylation	ESDGDSHSDKPGQPG CCCCCCCCCCCCCCC	51.81	29550500
324	Ubiquitination	LNSHSGVKMEEFLPP HHCCCCCCHHHCCCC	44.08	-
395	Phosphorylation	SGKLPRESDMEHSPS CCCCCCHHCCCCCCC	43.46	28973931
400	Phosphorylation	RESDMEHSPSGTEDS CHHCCCCCCCCCCCC	13.88	24453211
402	Phosphorylation	SDMEHSPSGTEDSLQ HCCCCCCCCCCCCCC	62.45	29550500
404	Phosphorylation	MEHSPSGTEDSLQPA CCCCCCCCCCCCCHH	40.74	29550500
407	Phosphorylation	SPSGTEDSLQPATDL CCCCCCCCCCHHHHH	23.75	25168779
433	Phosphorylation	AMPTKDASSDTELDK CCCCCCCCCCCCHHH	38.59	24453211
434	Phosphorylation	MPTKDASSDTELDKC CCCCCCCCCCCHHHH	50.72	25521595
436	Phosphorylation	TKDASSDTELDKCEK CCCCCCCCCHHHHHH	40.16	23737553
471	Ubiquitination	NFSYTKIKSEPSSPR CCCEEEECCCCCCCC	50.77	-
472	Phosphorylation	FSYTKIKSEPSSPRL CCEEEECCCCCCCCC	59.21	21659605
475	Phosphorylation	TKIKSEPSSPRLASS EEECCCCCCCCCCCC	49.26	25263469
476	Phosphorylation	KIKSEPSSPRLASSP EECCCCCCCCCCCCC	25.42	29514104
482	Phosphorylation	SSPRLASSPVQPNIG CCCCCCCCCCCCCCC	24.39	23649490
532	Phosphorylation	HRRLRHGSSSYPPVI HHHHHHCCCCCCCEE	15.24	29514104
534	Phosphorylation	RLRHGSSSYPPVIYS HHHHCCCCCCCEEEC	43.27	25338131
541	Phosphorylation	SYPPVIYSPLMPKGA CCCCEEECCCCCCCC	10.63	29514104
581	Phosphorylation	RWQQMAKSPEFPSVS HHHHHHHCCCCCCHH	21.81	21659605
723	Phosphorylation	PPLKRSASNKVPAMQ CCCCCCCCCCCHHHH	38.13	27149854
833	Phosphorylation	MDVPIDLSKKCLSQS EECCCCCCHHHCCHH	26.73	-
838	Phosphorylation	DLSKKCLSQSERTTA CCCHHHCCHHHCCCC	40.92	23737553
840	Phosphorylation	SKKCLSQSERTTASP CHHHCCHHHCCCCCC	26.18	23737553
846	Phosphorylation	QSERTTASPKRLLDY HHHCCCCCCHHHHHH	28.94	27149854
900	Phosphorylation	KVFPNPESERSSPEV EECCCCCCCCCCCCC	39.30	21659605
903	Phosphorylation	PNPESERSSPEVSFE CCCCCCCCCCCCCHH	46.31	21659605
904	Phosphorylation	NPESERSSPEVSFER CCCCCCCCCCCCHHH	31.16	21659605
908	Phosphorylation	ERSSPEVSFERNMIK CCCCCCCCHHHCCEE	21.52	29550500
915	Ubiquitination	SFERNMIKCEKNGNP CHHHCCEEEECCCCC	26.10	-
926	Phosphorylation	NGNPKQPSPNGNLFS CCCCCCCCCCCCCCH	28.62	25168779
955	Ubiquitination	AAQLIATKEENKHLF HHHHHCCHHHCCCCC	54.75	-
982	Phosphorylation	TKGADQLSPYYGIKP CCCCCCCCCCCCCCH	12.77	25338131
1014	Phosphorylation	STNTENESPKGQASS CCCCCCCCCCCCCCC	43.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOG2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOG2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOG2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FOG2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.