FLCN_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLCN_RAT
• UniProt AC: Q76JQ2
• Protein Name: Folliculin
• Gene Name: Flcn
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 579
• Subcellular Localization: Cytoplasm . Nucleus . Mainly localized in the nucleus. Colocalizes with FNIP1 and FNIP2 in the cytoplasm.
• Protein Description: May be a tumor suppressor. [PubMed: 14769940 May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity]
• Protein Sequence: MNAIVALCHFCELHGPRTLFCTEVLHAPLPQGAGSGDSPGQVEQAEEEEGGIQMSSRVRAHSPAEGASTDSSSPGPKKSDMCEGCRSLAVGHPGYISHDKETSIKYVSHQHPNHPQLFSIVRQACVRSLSCEVCPGREGPIFFGDEQHGFVFSHTFFIKDSLARGFQRWYSIIAIMMDRIYLINSWPFLLGKIRGIISELQGKALKVFEAEQFGCPQRAQRMNTAFTPFLHQRNGNAARSLTSLTSDDNLWACLHTSFAWLLKACGSRLTEKLLEGAPTEDTLVQMEKLADLEEESESWDNSEAEEEEKAPATAEGAEGRELASCPTESSFLSACGSWQPPKLSVFKSLRHMRQVLGAPSFRMLAWHVLMGNQVIWKSRDVNLVHSAFEVLRTMLPVGCVRIIPYSSQYEEAYRCNFLGLSPPVPIPAHVLASEFVVVVEVHTATRSNPHPAGCEDDQSLSKYEFVVTSGSPVAADRVGPTILNKMEAALTNQNLSVDVVDQCLVCLKEEWMNKVKVLFKFTKVDSRPKEDTQKLLSVLGASEEDNVKLLKFWMTGLSKTYKSHLMSTVRSPTAAESRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	SSRVRAHSPAEGAST CCCEEECCCCCCCCC	25.48	28689409
68	Phosphorylation	HSPAEGASTDSSSPG CCCCCCCCCCCCCCC	43.53	27097102
69	Phosphorylation	SPAEGASTDSSSPGP CCCCCCCCCCCCCCC	39.09	27097102
71	Phosphorylation	AEGASTDSSSPGPKK CCCCCCCCCCCCCCH	32.57	27097102
72	Phosphorylation	EGASTDSSSPGPKKS CCCCCCCCCCCCCHH	43.28	27097102
73	Phosphorylation	GASTDSSSPGPKKSD CCCCCCCCCCCCHHH	37.52	21738781
296	Phosphorylation	LADLEEESESWDNSE HHCHHHHHHCCCCHH	39.96	25575281
298	Phosphorylation	DLEEESESWDNSEAE CHHHHHHCCCCHHHH	49.35	29779826
302	Phosphorylation	ESESWDNSEAEEEEK HHHCCCCHHHHHHHH	35.39	19695222
313	Phosphorylation	EEEKAPATAEGAEGR HHHHCCCCCCCCCCC	24.96	25575281
406	Phosphorylation	CVRIIPYSSQYEEAY CEEEEECCCCCCHHH	12.95	-
537	Phosphorylation	EDTQKLLSVLGASEE HHHHHHHHHHCCCCH	26.23	-
542	Phosphorylation	LLSVLGASEEDNVKL HHHHHCCCCHHHHHH	39.46	-
563	Phosphorylation	GLSKTYKSHLMSTVR CCCHHHHHHHHHHCC	16.07	28432305
567	Phosphorylation	TYKSHLMSTVRSPTA HHHHHHHHHCCCCCH	30.06	28432305
568	Phosphorylation	YKSHLMSTVRSPTAA HHHHHHHHCCCCCHH	13.13	28432305
571	Phosphorylation	HLMSTVRSPTAAESR HHHHHCCCCCHHHHC	23.43	28432305
573	Phosphorylation	MSTVRSPTAAESRN- HHHCCCCCHHHHCC-	39.48	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLCN_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLCN_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLCN_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AAPK1_RAT	Prkaa1	physical	19914239

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.