FKBP6_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FKBP6_DROME
• UniProt AC: Q9W1I9
• Protein Name: Inactive peptidyl-prolyl cis-trans isomerase shutdown
• Gene Name: shu
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 455
• Subcellular Localization: Cytoplasm . Present in the cytoplasm of germ cells. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in Yb bodies.
• Protein Description: Co-chaperone required during oogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with Hsp83/HSP90 and is required for the biogenesis of all three piRNA major populations..
• Protein Sequence: MEENFEPYTPQLLKNPLSYSDLVKKGVEFEVDNSQQNHARDLGLDSDSDSDYEDALDVDGEELRSPWTYSFDELRALMSEIDENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEVIDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAATAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRACIMMKALRHLTMGNPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFSLKNSKSDVRKTPAQLEKEAKEQDFNDKMEDLIRRFKNTSDQQVSFSRKSYSNAQFDATCKLAKEHNLKLTLSPIQEDVLTLSKPDVKFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEENFEPYTPQLLKN CCCCCCCCCHHHHCC		22668510
18	Phosphorylation	QLLKNPLSYSDLVKK HHHCCCCCHHHHHHC		22817900
46	Phosphorylation	ARDLGLDSDSDSDYE HHHCCCCCCCCCCHH		19429919
48	Phosphorylation	DLGLDSDSDSDYEDA HCCCCCCCCCCHHHH		19429919
50	Phosphorylation	GLDSDSDSDYEDALD CCCCCCCCCHHHHCC		19429919
52	Phosphorylation	DSDSDSDYEDALDVD CCCCCCCHHHHCCCC		19429919
415	Phosphorylation	QVSFSRKSYSNAQFD CEEEECCCCCHHHHH		21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FKBP6_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FKBP6_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FKBP6_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of FKBP6_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.