FIS1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FIS1_RAT
• UniProt AC: P84817
• Protein Name: Mitochondrial fission 1 protein
• Gene Name: Fis1 {ECO:0000250|UniProtKB:Q9Y3D6}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 152
• Subcellular Localization: Mitochondrion outer membrane ; Single-pass membrane protein . Peroxisome membrane ; Single-pass membrane protein .
• Protein Description: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission (By similarity)..
• Protein Sequence: MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAVLNEL -------CHHHHHHC	7.23	-
10	Phosphorylation	AVLNELVSVEDLKNF HHHHHCCCHHHHHHH	32.20	-
29	Phosphorylation	QSEQAAGSVSKSTQF HHHHCCCCCCCCHHH	20.63	27097102
31	Phosphorylation	EQAAGSVSKSTQFEY HHCCCCCCCCHHHHH	23.68	28432305
46	Acetylation	AWCLVRSKYNDDIRR EHHHHHHHCCCHHHH	37.19	22902405
89	Acetylation	YRLKEYEKALKYVRG HHHHHHHHHHHHHHH	59.11	22902405
92	Acetylation	KEYEKALKYVRGLLQ HHHHHHHHHHHHHHC	46.70	22902405
108	Acetylation	EPQNNQAKELERLID CCCCHHHHHHHHHHH	53.74	22902405
108	Ubiquitination	EPQNNQAKELERLID CCCCHHHHHHHHHHH	53.74	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FIS1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FIS1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FIS1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of FIS1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.