FGF5_HUMAN - dbPTM
FGF5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FGF5_HUMAN
UniProt AC P12034
Protein Name Fibroblast growth factor 5
Gene Name FGF5
Organism Homo sapiens (Human).
Sequence Length 268
Subcellular Localization Secreted .
Protein Description Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)..
Protein Sequence MSLSFLLLLFFSHLILSAWAHGEKRLAPKGQPGPAATDRNPRGSSSRQSSSSAMSSSSASSSPAASLGSQGSGLEQSSFQWSPSGRRTGSLYCRVGIGFHLQIYPDGKVNGSHEANMLSVLEIFAVSQGIVGIRGVFSNKFLAMSKKGKLHASAKFTDDCKFRERFQENSYNTYASAIHRTEKTGREWYVALNKRGKAKRGCSPRVKPQHISTHFLPRFKQSEQPELSFTVTVPEKKKPPSPIKPKIPLSAPRKNTNSVKYRLKFRFG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
92PhosphorylationGRRTGSLYCRVGIGF
CCCCCCEEEEEEEEE
4.66-
104PhosphorylationIGFHLQIYPDGKVNG
EEEEEEECCCCCCCC
5.15-
110N-linked_GlycosylationIYPDGKVNGSHEANM
ECCCCCCCCCCHHHH
50.14UniProtKB CARBOHYD
110N-linked_GlycosylationIYPDGKVNGSHEANM
ECCCCCCCCCCHHHH
50.142005884
250PhosphorylationIKPKIPLSAPRKNTN
CCCCCCCCCCCCCCC
30.7624719451
261PhosphorylationKNTNSVKYRLKFRFG
CCCCCCEEEEEEECC
21.0130631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FGF5_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FGF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FGF5_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
EGF_HUMANEGFphysical
25241761
MK01_HUMANMAPK1physical
25241761
FGFR4_HUMANFGFR4physical
25241761

Drug and Disease Associations
Kegg Disease
OMIM Disease
190330Trichomegaly (TCMGLY)
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FGF5_HUMAN

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Related Literatures of Post-Translational Modification

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