FGF23_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGF23_HUMAN
• UniProt AC: Q9GZV9
• Protein Name: Fibroblast growth factor 23
• Gene Name: FGF23
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Secreted . Secretion is dependent on O-glycosylation.
• Protein Description: Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization..
• Protein Sequence: MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	TATARNSYHLQIHKN EECCCCCEEEEEECC	15.31	-
70	Phosphorylation	GAPHQTIYSALMIRS CCCCCCCEEEEEEEC	7.41	-
71	Phosphorylation	APHQTIYSALMIRSE CCCCCCEEEEEEECC	15.86	-
154	Phosphorylation	PGMNPPPYSQFLSRR CCCCCCCHHHHHHHC	22.37	-
155	Phosphorylation	GMNPPPYSQFLSRRN CCCCCCHHHHHHHCC	21.89	-
159	Phosphorylation	PPYSQFLSRRNEIPL CCHHHHHHHCCCCCE	30.40	-
178	O-linked_Glycosylation	TPIPRRHTRSAEDDS CCCCCCCCCCCCCCC	25.22	66730811
178	Phosphorylation	TPIPRRHTRSAEDDS CCCCCCCCCCCCCCC	25.22	-
180	Phosphorylation	IPRRHTRSAEDDSER CCCCCCCCCCCCCCC	36.85	-
207	Phosphorylation	TPAPASCSQELPSAE CCCCCCCCCCCCCCC	24.97	-
212	Phosphorylation	SCSQELPSAEDNSPM CCCCCCCCCCCCCCC	57.84	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
180	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	PSP
180	S	Phosphorylation	Kinase	FAM20C	Q5MJS3	PSP
207	S	Phosphorylation	Kinase	FAM20C	Q5MJS3	PSP
212	S	Phosphorylation	Kinase	FAM20C	Q5MJS3	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGF23_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGF23_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FGFR1_HUMAN	FGFR1	physical	22393163

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 193100: Hypophosphatemic rickets, autosomal dominant (ADHR)
• 211900: Tumoral calcinosis, hyperphosphatemic, familial (HFTC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.