FGD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FGD2_HUMAN
• UniProt AC: Q7Z6J4
• Protein Name: FYVE, RhoGEF and PH domain-containing protein 2
• Gene Name: FGD2
• Organism: Homo sapiens (Human).
• Sequence Length: 655
• Subcellular Localization: Cytoplasm, cytoskeleton . Cytoplasm. Nucleus. Early endosome. Early endosome membrane. Cell projection, ruffle membrane. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides..
• Protein Description: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity)..
• Protein Sequence: MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKGASEEKLASV ---CCCCCHHHHHHH	55.76	-
11	Phosphorylation	ASEEKLASVSNLVTV CCHHHHHHHHHHHHH	36.19	28857561
22	Phosphorylation	LVTVFENSRTPEAAP HHHHHCCCCCCCCCC	30.27	28348404
24	Phosphorylation	TVFENSRTPEAAPRG HHHCCCCCCCCCCCC	25.87	28348404
40 (in isoform 5)	Phosphorylation	-	17.52	30631047
48	Phosphorylation	PECRPPESPGPREKT CCCCCCCCCCCCCCC	40.71	30108239
67	Phosphorylation	AVGSEPRTVSRRYLN HCCCCCHHHHHHHHH	33.28	-
69	Phosphorylation	GSEPRTVSRRYLNSL CCCCHHHHHHHHHHH	15.49	-
72	Phosphorylation	PRTVSRRYLNSLKNK CHHHHHHHHHHHHHH	14.77	25003641
75	Phosphorylation	VSRRYLNSLKNKLSS HHHHHHHHHHHHCCH	37.82	25003641
81	Phosphorylation	NSLKNKLSSEAWRKS HHHHHHCCHHHHHHH	27.95	30108239
82	Phosphorylation	SLKNKLSSEAWRKSC HHHHHCCHHHHHHHC	41.59	30108239
230	Phosphorylation	VLTRIQSSEASGSLT HHHHHHCCCCCCCEE	22.32	-
235	Phosphorylation	QSSEASGSLTLQHHM HCCCCCCCEEEEECC	18.71	28857561
237	Phosphorylation	SEASGSLTLQHHMLE CCCCCCEEEEECCCC	26.52	28857561
304	Phosphorylation	LQDLWEVYQRLGLED HHHHHHHHHHHCCCC	4.03	-
350	Phosphorylation	LFNNMLLYCVPRVIQ HHHCHHHHHHHHHHH	6.35	21945579
395	Phosphorylation	LVSGKQRTLELQARS ECCCCCCEEEHHHHC	23.30	-
549	Phosphorylation	PDQSLMCSFLQLIGD CCHHHHHHHHHHHHH	18.28	-
561	Phosphorylation	IGDKWGKSGPRGWCV HHHCCCCCCCCCEEE	50.52	-
654	Phosphorylation	WPNDGDLSD------ CCCCCCCCC------	46.12	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FGD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FGD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FGD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TM239_HUMAN	TMEM239	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.