FFAR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FFAR2_HUMAN
• UniProt AC: O15552
• Protein Name: Free fatty acid receptor 2
• Gene Name: FFAR2
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. [PubMed: 12496283]
• Protein Sequence: MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
151	N-linked_Glycosylation	VIIVQYLNTTEQVRS EEEEECCCCCCHHHC	39.77	UniProtKB CARBOHYD
167	N-linked_Glycosylation	NEITCYENFTDNQLD CEEEEEECCCCCCCC	20.74	UniProtKB CARBOHYD
255	Dimethylation	QRKSPWWRSIAVVFS CCCCCHHHHHHHHHH	17.83	-
256	Phosphorylation	RKSPWWRSIAVVFSS CCCCHHHHHHHHHHH	10.94	-
281	Dimethylation	YFSSSVVRRAFGRGL HCCHHHHHHHHHHCH	23.27	-
286	Dimethylation	VVRRAFGRGLQVLRN HHHHHHHHCHHHHHH	35.87	-
296	Phosphorylation	QVLRNQGSSLLGRRG HHHHHCCCCCCCCCC	14.19	30108239
297	Phosphorylation	VLRNQGSSLLGRRGK HHHHCCCCCCCCCCC	34.14	30108239
324	Phosphorylation	GQGEGMPSSDFTTE- CCCCCCCCCCCCCC-	33.38	30108239
325	Phosphorylation	QGEGMPSSDFTTE-- CCCCCCCCCCCCC--	30.76	30108239
328	Phosphorylation	GMPSSDFTTE----- CCCCCCCCCC-----	34.70	30108239
329	Phosphorylation	MPSSDFTTE------ CCCCCCCCC------	39.43	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FFAR2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FFAR2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FFAR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGF1R_HUMAN	IGF1R	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.