FEZ1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEZ1_RAT
• UniProt AC: P97577
• Protein Name: Fasciculation and elongation protein zeta-1
• Gene Name: Fez1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 393
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell membrane. Colocalizes with both, alpha- and gamma-tubulin (By similarity). Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta..
• Protein Description: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules..
• Protein Sequence: MEAPLVSLDEEFEDIRPCCTEDPEEKPQSLYGTSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLRDEEVWDALTDNYIPSLSEDWRDPNIEALNGNSSDTEIHEKEEEDEFIEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEVEVLEEEDGGEISSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVHQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGADRQYLNTVIPYEKKSSPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	SEIISFKSMEDLVNE HHHCCCCCHHHHHHH	25.95	30411139
133	Phosphorylation	IEALNGNSSDTEIHE HHHHCCCCCCCCHHH	30.87	27097102
134	Phosphorylation	EALNGNSSDTEIHEK HHHCCCCCCCCHHHH	53.18	27097102
136	Phosphorylation	LNGNSSDTEIHEKEE HCCCCCCCCHHHHHH	38.49	27097102
299	Phosphorylation	RRKEKGLSLQSSRIE HHHHHCCCCHHHCHH	32.79	27097102
303	Phosphorylation	KGLSLQSSRIEKGNQ HCCCCHHHCHHCCCC	25.07	27097102
317	Phosphorylation	QMPLKRFSMEGISNI CCCCHHHCHHHHHHH	21.69	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEZ1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
26	K	ubiquitylation	Polyubiquitin linkage seems to be mainly through Lys-26 (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEZ1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of FEZ1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.