FES_MOUSE - dbPTM
FES_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FES_MOUSE
UniProt AC P16879
Protein Name Tyrosine-protein kinase Fes/Fps
Gene Name Fes
Organism Mus musculus (Mouse).
Sequence Length 822
Subcellular Localization Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Distributed throughout the cytosol when the kinase is not activated. Assoc
Protein Description Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28..
Protein Sequence MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
67PhosphorylationSWSSGPDSPVSQSWA
CCCCCCCCCCCHHHH		30.27-
161PhosphoglycerylationRKYQEASKDKDRDKA
HHHHHHHHCCCHHHH		75.69-
261PhosphorylationRIQPEFEYLGFLRQY
HHCCHHHHHHHHHHH		19.90-
393PhosphorylationSKMEQLGTGEPPAVP
HHHHHHCCCCCCCCC		47.1420531401
408PhosphorylationLLQDDRHSTSSTEQE
CCCCCCCCCCCCHHH		30.7730635358
409PhosphorylationLQDDRHSTSSTEQER
CCCCCCCCCCCHHHH		22.1420531401
410PhosphorylationQDDRHSTSSTEQERE
CCCCCCCCCCHHHHC		37.9730635358
411PhosphorylationDDRHSTSSTEQEREG
CCCCCCCCCHHHHCC		35.7320531401
412PhosphorylationDRHSTSSTEQEREGG
CCCCCCCCHHHHCCC		41.2630635358
421PhosphorylationQEREGGRTPTLEILK
HHHCCCCCCCHHHHH		24.7327180971
423PhosphorylationREGGRTPTLEILKSH
HCCCCCCCHHHHHHH		36.0922942356
432PhosphorylationEILKSHFSGIFRPKF
HHHHHHHCCCCCCCC		26.0924719451
440PhosphorylationGIFRPKFSIPPPLQL
CCCCCCCCCCCCCCC		40.0722345495
456PhosphorylationPEVQKPLYEQLWYHG
CCCCHHHHHHHHHCC		15.3422817900
461PhosphorylationPLYEQLWYHGAIPRA
HHHHHHHHCCCCCHH		10.0422345495
508PhosphorylationPRHFIIQSSDNLYRL
CCEEEEECCCCEEEC		29.2925159016
509PhosphorylationRHFIIQSSDNLYRLE
CEEEEECCCCEEECC		17.7225159016
513PhosphorylationIQSSDNLYRLEGDGF
EECCCCEEECCCCCC		21.2925159016
538PhosphorylationLSSQQPLTKKSGVVL
HCCCCCCCCCCCEEE		43.01-
700PhosphorylationEKNVLKISDFGMSRE
CCCEEEHHHCCCCHH		25.8725367039
713PhosphorylationREEADGIYAASAGLR
HHHHCCEEECCCCCC		11.1425177544
716PhosphorylationADGIYAASAGLRQVP
HCCEEECCCCCCCCC		18.0725367039
734PhosphorylationTAPEALNYGRYSSES
CCCCHHCCCCCCCHH		12.1129514104
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
713YPhosphorylationKinaseFESP16879
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FES_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FES_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of FES_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FES_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling.";
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.;
J. Immunol. 179:5864-5876(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-713, AND MASSSPECTROMETRY.

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