UniProt ID | FES_MOUSE | |
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UniProt AC | P16879 | |
Protein Name | Tyrosine-protein kinase Fes/Fps | |
Gene Name | Fes | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 822 | |
Subcellular Localization |
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane Peripheral membrane protein Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Distributed throughout the cytosol when the kinase is not activated. Assoc |
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Protein Description | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.. | |
Protein Sequence | MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
67 | Phosphorylation | SWSSGPDSPVSQSWA CCCCCCCCCCCHHHH | 30.27 | - | |
161 | Phosphoglycerylation | RKYQEASKDKDRDKA HHHHHHHHCCCHHHH | 75.69 | - | |
261 | Phosphorylation | RIQPEFEYLGFLRQY HHCCHHHHHHHHHHH | 19.90 | - | |
393 | Phosphorylation | SKMEQLGTGEPPAVP HHHHHHCCCCCCCCC | 47.14 | 20531401 | |
408 | Phosphorylation | LLQDDRHSTSSTEQE CCCCCCCCCCCCHHH | 30.77 | 30635358 | |
409 | Phosphorylation | LQDDRHSTSSTEQER CCCCCCCCCCCHHHH | 22.14 | 20531401 | |
410 | Phosphorylation | QDDRHSTSSTEQERE CCCCCCCCCCHHHHC | 37.97 | 30635358 | |
411 | Phosphorylation | DDRHSTSSTEQEREG CCCCCCCCCHHHHCC | 35.73 | 20531401 | |
412 | Phosphorylation | DRHSTSSTEQEREGG CCCCCCCCHHHHCCC | 41.26 | 30635358 | |
421 | Phosphorylation | QEREGGRTPTLEILK HHHCCCCCCCHHHHH | 24.73 | 27180971 | |
423 | Phosphorylation | REGGRTPTLEILKSH HCCCCCCCHHHHHHH | 36.09 | 22942356 | |
432 | Phosphorylation | EILKSHFSGIFRPKF HHHHHHHCCCCCCCC | 26.09 | 24719451 | |
440 | Phosphorylation | GIFRPKFSIPPPLQL CCCCCCCCCCCCCCC | 40.07 | 22345495 | |
456 | Phosphorylation | PEVQKPLYEQLWYHG CCCCHHHHHHHHHCC | 15.34 | 22817900 | |
461 | Phosphorylation | PLYEQLWYHGAIPRA HHHHHHHHCCCCCHH | 10.04 | 22345495 | |
508 | Phosphorylation | PRHFIIQSSDNLYRL CCEEEEECCCCEEEC | 29.29 | 25159016 | |
509 | Phosphorylation | RHFIIQSSDNLYRLE CEEEEECCCCEEECC | 17.72 | 25159016 | |
513 | Phosphorylation | IQSSDNLYRLEGDGF EECCCCEEECCCCCC | 21.29 | 25159016 | |
538 | Phosphorylation | LSSQQPLTKKSGVVL HCCCCCCCCCCCEEE | 43.01 | - | |
700 | Phosphorylation | EKNVLKISDFGMSRE CCCEEEHHHCCCCHH | 25.87 | 25367039 | |
713 | Phosphorylation | REEADGIYAASAGLR HHHHCCEEECCCCCC | 11.14 | 25177544 | |
716 | Phosphorylation | ADGIYAASAGLRQVP HCCEEECCCCCCCCC | 18.07 | 25367039 | |
734 | Phosphorylation | TAPEALNYGRYSSES CCCCHHCCCCCCCHH | 12.11 | 29514104 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
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713 | Y | Phosphorylation | Kinase | FES | P16879 | GPS |
Modified Location | Modified Residue | Modification | Function | Reference | ||
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Oops, there are no descriptions of PTM sites of FES_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
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Oops, there are no SNP-PTM records of FES_MOUSE !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
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Oops, there are no PPI records of FES_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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Phosphorylation | |
Reference | PubMed |
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-713, AND MASSSPECTROMETRY. |