FEN1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEN1_DROME
• UniProt AC: Q7K7A9
• Protein Name: Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}
• Gene Name: Fen1 {ECO:0000255|HAMAP-Rule:MF_03140}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 385
• Subcellular Localization: Nucleus, nucleolus . Nucleus, nucleoplasm . Mitochondrion . Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
• Protein Description: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA..
• Protein Sequence: MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVADADSIDLKWVEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGGRGRRPK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of FEN1_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEN1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEN1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEN1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.