FEM1B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FEM1B_MOUSE
• UniProt AC: Q9Z2G0
• Protein Name: Protein fem-1 homolog B
• Gene Name: Fem1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 627
• Subcellular Localization: Cytoplasm . Nucleus. Associated with chromatin..
• Protein Description: Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity)..
• Protein Sequence: MEGLAGYVYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLEHYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLDIVKYLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHIDIVKELIKWRAAIVVNGHGMTPLKVAAESCKADVVELLLSHADCDRRSRIEALELLGASFANDRENYDIMKTYHYLYLAMLERFQDGDNILEKEVLPPIHAYGNRTECRNPQELEAIRQDRDALHMEGLIVRERILGADNIDVSHPIIYRGAVYADNMEFEQCIKLWLHALHLRQKGNRNTHKDLLRFAQVFSQMIHLNEAVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHSAMDNYECNLYTFLYLVCISTKTQCSEEDQCRINKQIYNLIHLDPRTREGFSLLHLAVNSNTPVDDFHTNDVCSFPNALVTKLLLDCGAEVNAVDNEGNSALHIIVQYNRPISDFLTLHSIIISLVEAGAHTDMTNKQNKTPLDKSTTGVSEILLKTQMKMSLKCLAARAVRANDINYQDQIPRTLEEFVGFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
469	Ubiquitination	EDQCRINKQIYNLIH HHHHHHHHHHHHHHC	35.38	-
594	Ubiquitination	ILLKTQMKMSLKCLA HHHHHHHHHHHHHHH	18.60	27667366
598	Ubiquitination	TQMKMSLKCLAARAV HHHHHHHHHHHHHHH	21.64	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FEM1B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FEM1B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FEM1B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEM1B_HUMAN	FEM1B	physical	10542291
NKX31_MOUSE	Nkx3-1	physical	18816836

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.