FCGR2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCGR2_RAT
• UniProt AC: Q63203
• Protein Name: Low affinity immunoglobulin gamma Fc region receptor II
• Gene Name: Fcgr2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 285
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens..
• Protein Sequence: MDSNRTVVHVLSRTLYHMLLWTAVLNLVAESHAGLPKAVVKLEPPWIQVLKEDTVTLMCEGTHNTKNCSTQWFHNGSSIWHQAQANYTFKATVNDSGEYRCRMEETGISEPIHLGVISDWLLLQTSQLVFEEGETITLRCHSWKNKQLTKVLLFQNGKPVRYYHQSSNFSIPKANHSHSGNYYCKAYLGRTMHVSKPVTITVQEPKSSSSLPVLTIVAAVAGIAVAAIVIILVSLVYLKKKQVPDTPSGLEEAEKNEVENTITYSLLKHPEAPDEESDHDYQNHI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	N-linked_Glycosylation	EGTHNTKNCSTQWFH CCCCCCCCCCEEEEE	23.96	-
75	N-linked_Glycosylation	CSTQWFHNGSSIWHQ CCEEEEECCCCHHEE	42.44	-
86	N-linked_Glycosylation	IWHQAQANYTFKATV HHEEEEEEEEEEEEE	25.05	-
94	N-linked_Glycosylation	YTFKATVNDSGEYRC EEEEEEECCCCCEEE	33.12	-
168	N-linked_Glycosylation	RYYHQSSNFSIPKAN EEEEECCCCCCCCCC	39.67	-
175	N-linked_Glycosylation	NFSIPKANHSHSGNY CCCCCCCCCCCCCCE	43.23	-
246	Phosphorylation	KKKQVPDTPSGLEEA HHCCCCCCCCCCHHH	17.18	30181290
248	Phosphorylation	KQVPDTPSGLEEAEK CCCCCCCCCCHHHHH	59.09	22673903
261	Phosphorylation	EKNEVENTITYSLLK HHHHCCCHHHHHHHC	10.94	23984901
263	Phosphorylation	NEVENTITYSLLKHP HHCCCHHHHHHHCCC	12.67	23984901
264	Phosphorylation	EVENTITYSLLKHPE HCCCHHHHHHHCCCC	8.09	30181290
265	Phosphorylation	VENTITYSLLKHPEA CCCHHHHHHHCCCCC	20.69	23984901
277	Phosphorylation	PEAPDEESDHDYQNH CCCCCCCCCCCCCCC	37.89	29779826
281	Phosphorylation	DEESDHDYQNHI--- CCCCCCCCCCCC---	14.06	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
264	Y	Phosphorylation	Kinase	SRC-TYPE TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCGR2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCGR2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of FCGR2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.