dbPTM

FCERB_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FCERB_RAT
UniProt AC	P13386
Protein Name	High affinity immunoglobulin epsilon receptor subunit beta
Gene Name	Ms4a2
Organism	Rattus norvegicus (Rat).
Sequence Length	243
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy..
Protein Sequence	MDTENKSRADLALPNPQESPSAPDIELLEASPPAKALPEKPASPPPQQTWQSFLKKELEFLGVTQVLVGLICLCFGTVVCSTLQTSDFDDEVLLLYRAGYPFWGAVLFVLSGFLSIMSERKNTLYLVRGSLGANIVSSIAAGLGIAILILNLSNNSAYMNYCKDITEDDGCFVTSFITELVLMLLFLTILAFCSAVLLIIYRIGQEFERSKVPDDRLYEELHVYSPIYSALEDTREASAPVVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
218	Phosphorylation	KVPDDRLYEELHVYS CCCCCHHHHHHHHHC	14.30	22817900
224	Phosphorylation	LYEELHVYSPIYSAL HHHHHHHHCHHHHHH	9.66	22817900
225	Phosphorylation	YEELHVYSPIYSALE HHHHHHHCHHHHHHH	12.06	-
228	Phosphorylation	LHVYSPIYSALEDTR HHHHCHHHHHHHHHH	7.41	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FCERB_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FCERB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FCERB_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
LYN_RAT	Lyn	physical	19356729
AKT1_RAT	Akt1	physical	19356729

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FCERB_RAT

Related Literatures of Post-Translational Modification