FCER2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FCER2_HUMAN
• UniProt AC: P06734
• Protein Name: Low affinity immunoglobulin epsilon Fc receptor
• Gene Name: FCER2
• Organism: Homo sapiens (Human).
• Sequence Length: 321
• Subcellular Localization: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Also exists as a soluble excreted form, sCD23.
• Protein Description: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen)..
• Protein Sequence: MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEEGQYSEIEELPR -CCCCCCHHHHHCCH	24.98	30108239
17	S-palmitoylation	EELPRRRCCRRGTQI HHCCHHCCCHHCCHH	1.69	22615937
18	S-palmitoylation	ELPRRRCCRRGTQIV HCCHHCCCHHCCHHH	2.93	22615937
63	N-linked_Glycosylation	LEERAARNVSQVSKN HHHHHHHHHHHHHHH	32.82	UniProtKB CARBOHYD
85	Phosphorylation	QMAQKSQSTQISQEL HHHHHHHHHHHHHHH	29.39	27251275
86	Phosphorylation	MAQKSQSTQISQELE HHHHHHHHHHHHHHH	23.45	27251275
89	Phosphorylation	KSQSTQISQELEELR HHHHHHHHHHHHHHH	14.05	27251275
155	O-linked_Glycosylation	LRMELQVSSGFVCNT HHHEEECCCCCCCCC	16.28	OGP
254	Phosphorylation	PGEPTSRSQGEDCVM CCCCCCCCCCCCCEE	42.16	-
265	Phosphorylation	DCVMMRGSGRWNDAF CCEEECCCCCCCCHH	18.15	-
314	Phosphorylation	DPDGRLPTPSAPLHS CCCCCCCCCCCCCCC	34.17	-
314	O-linked_Glycosylation	DPDGRLPTPSAPLHS CCCCCCCCCCCCCCC	34.17	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FCER2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FCER2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FCER2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATF7_HUMAN	ATF7	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.