dbPTM

FBXL8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FBXL8_MOUSE
UniProt AC	Q8CIG9
Protein Name	F-box/LRR-repeat protein 8
Gene Name	Fbxl8
Organism	Mus musculus (Mouse).
Sequence Length	374
Subcellular Localization
Protein Description	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence	MGELVDNLPEEVLALIFRDLPLRDLAVATRVCRAWAAAAANSTVWSDKSISCDCELEDLLPPYLSSCLDHIHNLRLEYEPSKKPSRGTATELLTALASRAPRLRGLRLECRGEKPLFDAGQDILGAVHAVCGAAHQLRHLDLRHLPYTLDDTLVLKAAAGCPELRSLFLDNHALVNSVQPTSVLKLLEACPHLRALGLHLASMSRAALELLAAPHRSPFALLALRCACPEDARASPLPDEAWATLSCRHPGLEVELELEPVLPDEAVTRILQPAVPVAVLRLNLSGDTVGPVRFATRHYAETLRALEVRASASPELHTALEELAARCAGLREIHCFCVVRPSVLDAFRAHCPRLRSYTLKLKREPHPWRPTLVR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
147	Phosphorylation	LDLRHLPYTLDDTLV CCCCCCCCCCCHHHH	26.71	28507225
152	Phosphorylation	LPYTLDDTLVLKAAA CCCCCCHHHHHHHHC	20.59	28507225

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FBXL8_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FBXL8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FBXL8_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FBXL8_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FBXL8_MOUSE

Related Literatures of Post-Translational Modification