FBXL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBXL2_MOUSE
• UniProt AC: Q8BH16
• Protein Name: F-box/LRR-repeat protein 2 {ECO:0000305}
• Gene Name: Fbxl2 {ECO:0000312|MGI:MGI:1919429}
• Organism: Mus musculus (Mouse).
• Sequence Length: 423
• Subcellular Localization: Membrane ; Lipid-anchor .
• Protein Description: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant. [PubMed: 21343341]
• Protein Sequence: MVFSNSDDGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNHCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMDLEECVLITDSTLVQLSIHCPKLQALSLSHCELITDEGILHLSSSTCGHERLRVLELDNCLLVTDASLEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPPAVAGSGHRLCRCCVIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
84	Phosphorylation	GGFLRKLSLRGCIGV CHHHHHCCCCCCCCC	21.03	22942356
404	Phosphorylation	HAYFAPVTPPPAVAG EEEECCCCCCCCCCC	29.08	28418008
420	Geranylgeranylation	GHRLCRCCVIL---- CCEEEEEEEEC----	0.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBXL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBXL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBXL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCND3_MOUSE	Ccnd3	physical	22020328
CCND3_MOUSE	Ccnd3	physical	22024926
TCPA_MOUSE	Tcp1	physical	21343341

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.