FBX41_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX41_HUMAN
• UniProt AC: Q8TF61
• Protein Name: F-box only protein 41
• Gene Name: FBXO41
• Organism: Homo sapiens (Human).
• Sequence Length: 875
• Protein Description: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
• Protein Sequence: MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	GEHKRFRSLSSLRAH CCCHHHHCHHHHHHH	29.86	22167270
23	Phosphorylation	HKRFRSLSSLRAHLE CHHHHCHHHHHHHHH	28.68	22167270
24	Phosphorylation	KRFRSLSSLRAHLEY HHHHCHHHHHHHHHH	27.45	22167270
37	Phosphorylation	EYSHTYETLYILSKT HHHCHHHHEEEEECC	17.91	-
39	Phosphorylation	SHTYETLYILSKTNS HCHHHHEEEEECCCC	13.77	17081983
212	Ubiquitination	LKIRALEKLEVDRRL HHHHHHHHHHHHHHH	51.28	29967540
229	Ubiquitination	LSEEVEQKIAGQVGR HCHHHHHHHHHHHHH	22.48	30230243
244	Ubiquitination	LQAELERKAAELETA HHHHHHHHHHHHHHH	42.44	29967540
287	Ubiquitination	VELLASLKQDLVHKE HHHHHHHHHHHHHHH	38.99	30230243
293	Ubiquitination	LKQDLVHKEQELSRK HHHHHHHHHHHHHHH	54.32	29967540
312	Ubiquitination	VQIDQFLKETAAREA HHHHHHHHHHHHHHH	55.07	29967540
360	Methylation	TPSASLGRGGGGGGA CCCCCCCCCCCCCCC	45.97	-
372	Methylation	GGAGPNARGPGRMRE CCCCCCCCCCCCCCC	59.48	-
389	Phosphorylation	VGPAVPNTYAVSRHG CCCCCCCCEEECCCC	13.54	29978859
390	Phosphorylation	GPAVPNTYAVSRHGS CCCCCCCEEECCCCC	16.20	29978859
393	Phosphorylation	VPNTYAVSRHGSSPS CCCCEEECCCCCCCC	15.47	29978859
478	Phosphorylation	QRRPRRHSTEGEEGD HHCCCCCCCCCCCCC	26.75	23401153
479	Phosphorylation	RRPRRHSTEGEEGDV HCCCCCCCCCCCCCH	41.71	29255136
487	Phosphorylation	EGEEGDVSDVGSRTT CCCCCCHHHCCCCCC	31.17	23927012
530	Methylation	RPEGGSGRGRRAERV CCCCCCCCCCCCCCC	36.82	-
538	Phosphorylation	GRRAERVSPSRSNEV CCCCCCCCCCCCCCC	24.31	30576142
540	Phosphorylation	RAERVSPSRSNEVIS CCCCCCCCCCCCCCC	40.61	28102081
542	Phosphorylation	ERVSPSRSNEVISPE CCCCCCCCCCCCCHH	41.50	-
547	Phosphorylation	SRSNEVISPEILKMR CCCCCCCCHHHHHHH	22.96	24076635
632	Phosphorylation	RQRGKKESKEEYARS HHCCCHHHHHHHHHH	55.00	-
636	Phosphorylation	KKESKEEYARSTRGC CHHHHHHHHHHHHHH	14.38	-
650	Phosphorylation	CLEAGLESLLKAAGG HHHHHHHHHHHHCCC	44.00	24719451
762	Phosphorylation	CGVQGLASLARNCMR HHHHHHHHHHHHCCC	27.83	-
817	Phosphorylation	KALLHFNSICRNLKS HHHHHHHHHHHCHHH	23.32	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX41_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX41_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX41_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of FBX41_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.