dbPTM

FBX34_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FBX34_MOUSE
UniProt AC	Q80XI1
Protein Name	F-box only protein 34
Gene Name	Fbxo34
Organism	Mus musculus (Mouse).
Sequence Length	695
Subcellular Localization
Protein Description	Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex..
Protein Sequence	MHLKLYWKLQKKERPLEVSRDTLRTPMSHGKANGDVKARASYMKPTVLPSASLVKASSRKPFGILSPNVLCSMSGKSPVENSLNVKAKKNVLSAAVHQSEEGLPGTWAIVKPGNTKEKIAFFAAHQYSNRIGSMKIKSSWDIDGRATKRRKKSGDLKKAKLQLEMMREINSQCYQSEPFVCGVEHCSVHYMSDSGDGVCAARPLSVIQMVAFLEQKATALLASCTKNCTNSPAIVKISGQSRGIPPAPEPFSAPETCEEPKEQENPETGRSQGEPVRVLDMVARLESECLKHQGQREPGSLSRNNSFRRNVGRVLLTNGSQASDKSEEGSADTADPQENPLQPVSVGEEPSVTEHHSVGEQAWDGTSQSCPSLPATVSFHMDSTDLEPGQQTAMKSCSRDDVEMVEEFDELPTDAVRRIRRELVTVTKHSPEQRQDPLCISITVCTVEKDRPAALDSLEEPLPGMLFFLSSGQDQQAHPQLREHPAPEASEASQPQDAAEGSSAGEEKDASVEPLLPAASPGGSTSQVLEAATCKKQVSQDFLETRFKIQQLLEPQQYMACLPHHIIVKIFRLLPTLSLAILKCTCRYFKSIIEYYNIRPADSRWVRDPRYREDPCKQCKKKYVKGDVSLCRWHPKPYCQALPYGPGYWMCCHQSQKGFPGCKLGLHDNHWLPACHSFNRAIHKKTRGSETEEEY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	RASYMKPTVLPSASL CHHHCCCCCCCCHHH	29.20	28059163
50	Phosphorylation	MKPTVLPSASLVKAS CCCCCCCCHHHEECC	26.74	28059163
52	Phosphorylation	PTVLPSASLVKASSR CCCCCCHHHEECCCC	37.72	28059163
57	Phosphorylation	SASLVKASSRKPFGI CHHHEECCCCCCCCC	25.59	28059163
152	Acetylation	RATKRRKKSGDLKKA CHHCCHHCCCCHHHH	58.84	15611835
226	Ubiquitination	ALLASCTKNCTNSPA HHHHHHCCCCCCCCE	55.11	-
241	Phosphorylation	IVKISGQSRGIPPAP EEEECCCCCCCCCCC	35.68	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FBX34_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FBX34_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FBX34_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FBX34_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FBX34_MOUSE

Related Literatures of Post-Translational Modification