| UniProt ID | FBW10_HUMAN | |
|---|---|---|
| UniProt AC | Q5XX13 | |
| Protein Name | F-box/WD repeat-containing protein 10 | |
| Gene Name | FBXW10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1052 | |
| Subcellular Localization | ||
| Protein Description | Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1.. | |
| Protein Sequence | MENLESRLKNAPYFRCEKGTDSIPLCRKCETCVLAWKIFSTKEWFCRINDISQRRFLVGILKQLNSLYLLHYFQNILQTTQGKDFIYNRSRINLSKKEGKVVKSSLNQMLDKTVEQKMKEILYWFANSTQWTKANYTLLLLQMCNPKLLLTAANVIRVLFLREENNISGLNQDITDVCFSPEKDHSSKSATSQVYWTAKTQHTSLPLSKAPENEHLLGAASNPEEPWRNSLRCISEMNRLFSGKGDITKPGYDPCNLLVDLDDIRDLSSGFSKYRDFIRYLPIHLSKYILRMLDRHTLNKCASVSQHWAAMAQQVKMDLSAHGFIQNQITFLQGSYTRGIDPNYANKVSIPVPKMVDDGKSMRVKHPKWKLRTKNEYNLWTAYQNEETQQVLIEERNVFCGTYNVRILSDTWDQNRVIHYSGGDLIAVSSNRKIHLLDIIQVKAIPVEFRGHAGSVRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTITCMDLCKNRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILATRINDTYIVSSCERGLVKVWHIAMAQLVKTLSGHEGAVKCLFFDQWHLLSGSTDGLVMAWSMVGKYERCLMAFKHPKEVLDVSLLFLRVISACADGKIRIYNFLNGNCMKVLKANGRGDPVLSFFIQGNRMVVNTESNVLMFQFEHIKWQYAVEKTKQKKNKEKEEEKEENSLMEILSKCNIQVHSPRESVSSKQTVIQELLPGKPPKSRVLLKPAKFSSAVLIEELQSQGKSKSPRRDADDVEKAQKQGQLETPGKLPSHPKKKSWKIPMSPDQFLLTVSALQHAHNSGEFAYPCRPQTEITDVWGPSISYPRKVLNFKGKSIQRAVDRLRLSNPPIDVKRTSIPLEIQKLQPNLKISLHSPRVQSTIPQPMIIRSRFSGSLKGGDQVTSSIERAVCSTGPLTSMQVIKPNRMLAPQVGTATLSLKKERPRIYTALDPFRVNTEFVLLTVKEEKEHQEAKMKEYQARESTGVVDPGKVSKAAWIRKIKGLPIDNFTKQGKTAAPELGQNVFI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | SRLKNAPYFRCEKGT HHHHCCCCCCCCCCC | 10.97 | - | |
| 235 | Phosphorylation | RNSLRCISEMNRLFS HHHHHHHHHHHHHHC | 34.12 | 28258704 | |
| 242 | Phosphorylation | SEMNRLFSGKGDITK HHHHHHHCCCCCCCC | 44.16 | - | |
| 268 | Phosphorylation | LDDIRDLSSGFSKYR HHHHHHHHCCCHHHH | 32.48 | - | |
| 269 | Phosphorylation | DDIRDLSSGFSKYRD HHHHHHHCCCHHHHH | 51.67 | 19276368 | |
| 286 (in isoform 2) | Phosphorylation | - | 14.84 | - | |
| 303 | Phosphorylation | HTLNKCASVSQHWAA HHHHHHHHHHHHHHH | 31.60 | 22210691 | |
| 349 | Phosphorylation | PNYANKVSIPVPKMV CCCCCCCCCCCCCCC | 23.84 | 24719451 | |
| 476 | Phosphorylation | LSGSYDLSIRYWDLK EEEEEEEEEEEEECC | 11.34 | 24719451 | |
| 545 | Phosphorylation | LATRINDTYIVSSCE EEEEECCEEEECCCC | 15.62 | 26852163 | |
| 546 | Phosphorylation | ATRINDTYIVSSCER EEEECCEEEECCCCC | 11.37 | 26852163 | |
| 549 | Phosphorylation | INDTYIVSSCERGLV ECCEEEECCCCCCHH | 21.51 | 26852163 | |
| 550 | Phosphorylation | NDTYIVSSCERGLVK CCEEEECCCCCCHHH | 14.76 | 26852163 | |
| 605 | Phosphorylation | AWSMVGKYERCLMAF HHHHHCHHHHHHHHC | 11.59 | - | |
| 711 | O-linked_Glycosylation | EEEKEENSLMEILSK HHHHHHHHHHHHHHH | 32.16 | 30379171 | |
| 711 | Phosphorylation | EEEKEENSLMEILSK HHHHHHHHHHHHHHH | 32.16 | 30622161 | |
| 717 | Phosphorylation | NSLMEILSKCNIQVH HHHHHHHHHCCCEEC | 40.60 | 30622161 | |
| 758 | Phosphorylation | LLKPAKFSSAVLIEE EECCCCCCHHHHHHH | 19.38 | 30622161 | |
| 759 | Phosphorylation | LKPAKFSSAVLIEEL ECCCCCCHHHHHHHH | 26.06 | 30622161 | |
| 793 | Phosphorylation | QKQGQLETPGKLPSH HHHCCCCCCCCCCCC | 46.03 | 28152594 | |
| 799 | Phosphorylation | ETPGKLPSHPKKKSW CCCCCCCCCCCCCCC | 63.96 | 28152594 | |
| 960 | Phosphorylation | MLAPQVGTATLSLKK CCCCCCCEEEEEECC | 20.01 | - | |
| 964 | Phosphorylation | QVGTATLSLKKERPR CCCEEEEEECCCCCC | 33.51 | - | |
| 973 | Phosphorylation | KKERPRIYTALDPFR CCCCCCEEEECCCCC | 6.29 | 22115753 | |
| 974 | Phosphorylation | KERPRIYTALDPFRV CCCCCEEEECCCCCC | 20.55 | 22115753 | |
| 989 | Phosphorylation | NTEFVLLTVKEEKEH CCCEEEEEECHHHHH | 25.93 | 22115753 | |
| 1004 | Phosphorylation | QEAKMKEYQARESTG HHHHHHHHHHHHCCC | 11.27 | - | |
| 1036 | Phosphorylation | GLPIDNFTKQGKTAA CCCCCCCCCCCCCCC | 28.81 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FBW10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FBW10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FBW10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of FBW10_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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