FANCJ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FANCJ_MOUSE
• UniProt AC: Q5SXJ3
• Protein Name: Fanconi anemia group J protein homolog
• Gene Name: Brip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1174
• Subcellular Localization: Nucleus.
• Protein Description: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (By similarity)..
• Protein Sequence: MSSVLSDYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAWQQSLSEKPVDEGLNKKPEAPPSCSCACHSKNFTYSDTNLDTSPHFNSPSKPSSGRNGVSTPCQDSPEKNTLAAKLSAKKQASIHRDEDDDFQVEKKRIRPLETTQQIRKRHCLEKDVHHVDARLASEKRVKPESPIGKSFSDRKDSFQNVDGLCSRCCCSAKQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHSCVHPEVVGNFNRKEKCMELLDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSKHLVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVNALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSKSRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQIQHHSSFASALESLTEFSRRHQKVTNRSKKDEKCTKDNEPTLEVACLEDSTFTSVSESSHQSPENSTEEAEVCVQELQCPQVATKSPSVASHGVSRRKKSDPGLRGESLQTMKTEKNEISRSSSPTFGKQTEPVNWPIFNSLRRHFNSKVKNCTPVLKSSKNRAPGSSTFNKTALPLTGNCVPSNETADTSLGPCLQSEVIISPVKIEATPATNYSKQVFCCEKDLLPDTELSPGTEEAKCPSSNKAAETEVDDDSECFTPELFDPVDTNEENGELVETDRSSHSSDCFSAEELFETATGFGQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	YSDTNLDTSPHFNSP CCCCCCCCCCCCCCC	47.53	26643407
105	Phosphorylation	SDTNLDTSPHFNSPS CCCCCCCCCCCCCCC	18.95	26643407
110	Phosphorylation	DTSPHFNSPSKPSSG CCCCCCCCCCCCCCC	29.61	25619855
112	Phosphorylation	SPHFNSPSKPSSGRN CCCCCCCCCCCCCCC	57.95	25619855
128	Phosphorylation	VSTPCQDSPEKNTLA CCCCCCCCCCCCCHH	14.74	25266776
133	Phosphorylation	QDSPEKNTLAAKLSA CCCCCCCCHHHHHCH	28.92	24759943
139	Phosphorylation	NTLAAKLSAKKQASI CCHHHHHCHHHHHHC	37.02	25338131
189	Phosphorylation	HVDARLASEKRVKPE HHHHHHHHCCCCCCC	48.52	27149854
197	Phosphorylation	EKRVKPESPIGKSFS CCCCCCCCCCCCCHH	30.28	26824392
209	Phosphorylation	SFSDRKDSFQNVDGL CHHCCCHHCCCCCCH	31.59	27149854
621	Phosphorylation	VLTSGTLSPLKSFSS EEECCCCCCCHHCCC	28.20	21183079
750	Ubiquitination	QVYYDAIKFKGEKDG HHHHHHHHCCCCCCC	42.62	-
755	Ubiquitination	AIKFKGEKDGALLIA HHHCCCCCCCEEEEE	70.86	-
929	Phosphorylation	FTSVSESSHQSPENS EEECCCCCCCCCCCC	22.84	-
932	Phosphorylation	VSESSHQSPENSTEE CCCCCCCCCCCCHHH	28.85	-
956	Phosphorylation	CPQVATKSPSVASHG CCHHHCCCCCHHHCC	20.32	29472430
958	Phosphorylation	QVATKSPSVASHGVS HHHCCCCCHHHCCCC	37.09	29472430
970	Phosphorylation	GVSRRKKSDPGLRGE CCCCCCCCCCCCCCC	52.66	24719451
990	Phosphorylation	KTEKNEISRSSSPTF HHCCCHHCCCCCCCC	21.67	23375375
992	Phosphorylation	EKNEISRSSSPTFGK CCCHHCCCCCCCCCC	28.51	28066266
993	Phosphorylation	KNEISRSSSPTFGKQ CCHHCCCCCCCCCCC	38.95	28066266
994	Phosphorylation	NEISRSSSPTFGKQT CHHCCCCCCCCCCCC	29.25	24453211
996	Phosphorylation	ISRSSSPTFGKQTEP HCCCCCCCCCCCCCC	47.14	28066266
1068	Phosphorylation	SLGPCLQSEVIISPV CCHHHCCCEEEEECE	22.38	26745281
1073	Phosphorylation	LQSEVIISPVKIEAT CCCEEEEECEEEECC	16.71	26745281
1100	Phosphorylation	EKDLLPDTELSPGTE CHHCCCCCCCCCCCC	36.56	25619855
1103	Phosphorylation	LLPDTELSPGTEEAK CCCCCCCCCCCCCCC	18.30	22942356
1106	Phosphorylation	DTELSPGTEEAKCPS CCCCCCCCCCCCCCC	33.75	25619855
1174	Acetylation	TATGFGQK------- HHHCCCCC-------	63.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FANCJ_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FANCJ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FANCJ_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FANCJ_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.