FAF1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAF1_RAT
• UniProt AC: Q924K2
• Protein Name: FAS-associated factor 1
• Gene Name: Faf1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 649
• Subcellular Localization: Nucleus .
• Protein Description: Ubiquitin-binding protein. Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation. Potentiates but cannot initiate FAS-induced apoptosis..
• Protein Sequence: MASNMDREMILADFQACTGIENIDEAITLLEQNNWDLVAAINGVIPQENGILQSDFGGETMPGPTFDPASPPAPAPAPSSSAFRPVMPSRQIVERQPRMLDFRVEYRDRNVDVVLEDSCTVGEIKQILENELQIPVPKMLLKGWKTGDVEDSTVLKSLHLPKNNSLYVLTPDLPPPSSSSHAGALQESLNQNFMLIITHREVQREYNLNFSGSSTVQEVKRNVYDLTSIPVRHQLWEGWPASATDDSMCLAESGLSYPCHRLTVGRRTSPVQTREQSEEQSTVVHMVSDSDGDDFEDASEFGVVDGEVFGMASSTMRKSPMMPENAENEGDALLQFTAEFSSRYGDCHPVFFIGSLEAAFQEAFYVKARDRKLLAIYLHHDESVLTNVFCSQMLCAESIVSYLSQNFITWAWDLTKDANRARFLTMCNRHFGSVIAQTIRTQKTDQFPLFLIIMGKRSSNEVLNVIQGNTTVDELMMRLMAAMEIFSAQQQEDIKDEDEREARENVKREQDEAYRLSLEADRAKREAHEREMAEQFRLEQIRKEQEEEREAIRLSLEQALPPEPEEENAEPVSKLRIRTPSGEFLERRFLASNKLQIVFDFVASKGFPWDEFKLLSTFPRRDVTQLDPNKSLLEVNLFPQETLFLLAKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Ubiquitination	VEDSTVLKSLHLPKN CCCCCHHEEEECCCC	46.78	-
268	Phosphorylation	RLTVGRRTSPVQTRE ECCCCCCCCCCCCHH	35.70	22673903
269	Phosphorylation	LTVGRRTSPVQTREQ CCCCCCCCCCCCHHC	22.66	23298284
273	Phosphorylation	RRTSPVQTREQSEEQ CCCCCCCCHHCCCCC	36.09	22673903
319	Phosphorylation	ASSTMRKSPMMPENA CCCCCCCCCCCCCCC	13.99	29779826
573	Phosphorylation	EENAEPVSKLRIRTP CCCCCCCCCCEEECC	36.37	25575281
579	Phosphorylation	VSKLRIRTPSGEFLE CCCCEEECCCHHHHH	21.31	28432305
581	Phosphorylation	KLRIRTPSGEFLERR CCEEECCCHHHHHHH	50.79	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAF1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAF1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRPV1_RAT	Trpv1	physical	16510717

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.