FAAA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAAA_MOUSE
• UniProt AC: P35505
• Protein Name: Fumarylacetoacetase
• Gene Name: Fah
• Organism: Mus musculus (Mouse).
• Sequence Length: 419
• Protein Sequence: MSFIPVAEDSDFPIQNLPYGVFSTQSNPKPRIGVAIGDQILDLSVIKHLFTGPALSKHQHVFDETTLNNFMGLGQAAWKEARASLQNLLSASQARLRDDKELRQRAFTSQASATMHLPATIGDYTDFYSSRQHATNVGIMFRGKENALLPNWLHLPVGYHGRASSIVVSGTPIRRPMGQMRPDNSKPPVYGACRLLDMELEMAFFVGPGNRFGEPIPISKAHEHIFGMVLMNDWSARDIQQWEYVPLGPFLGKSFGTTISPWVVPMDALMPFVVPNPKQDPKPLPYLCHSQPYTFDINLSVSLKGEGMSQAATICRSNFKHMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGSDPESFGSMLELSWKGTKAIDVEQGQTRTFLLDGDEVIITGHCQGDGYRVGFGQCAGKVLPALSPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFIPVAED ------CCCCCCCCC	31.70	22324799
2	Acetylation	------MSFIPVAED ------CCCCCCCCC	31.70	-
10	Phosphorylation	FIPVAEDSDFPIQNL CCCCCCCCCCCCCCC	32.43	22324799
19	Phosphorylation	FPIQNLPYGVFSTQS CCCCCCCCCEEECCC	29.14	23984901
23	Phosphorylation	NLPYGVFSTQSNPKP CCCCCEEECCCCCCC	24.11	23984901
24	Phosphorylation	LPYGVFSTQSNPKPR CCCCEEECCCCCCCC	25.26	23984901
26	Phosphorylation	YGVFSTQSNPKPRIG CCEEECCCCCCCCEE	56.01	23984901
29	Acetylation	FSTQSNPKPRIGVAI EECCCCCCCCEEEEE	51.70	23954790
47	Acetylation	ILDLSVIKHLFTGPA ECCHHHHHHHHHCCC	31.90	23954790
47	Malonylation	ILDLSVIKHLFTGPA ECCHHHHHHHHHCCC	31.90	26073543
51	Phosphorylation	SVIKHLFTGPALSKH HHHHHHHHCCCHHCC	48.92	22817900
56	Phosphorylation	LFTGPALSKHQHVFD HHHCCCHHCCCCCCC	30.14	23984901
57	Acetylation	FTGPALSKHQHVFDE HHCCCHHCCCCCCCH	48.40	23954790
57	Malonylation	FTGPALSKHQHVFDE HHCCCHHCCCCCCCH	48.40	26320211
79	Acetylation	GLGQAAWKEARASLQ HHHHHHHHHHHHHHH	36.45	23954790
84	Phosphorylation	AWKEARASLQNLLSA HHHHHHHHHHHHHHH	25.57	25521595
90	Phosphorylation	ASLQNLLSASQARLR HHHHHHHHHHHHHHC	29.10	22324799
92	Phosphorylation	LQNLLSASQARLRDD HHHHHHHHHHHHCCC	22.46	25521595
100	Ubiquitination	QARLRDDKELRQRAF HHHHCCCHHHHHHHH	64.04	-
100	Malonylation	QARLRDDKELRQRAF HHHHCCCHHHHHHHH	64.04	26320211
100	Acetylation	QARLRDDKELRQRAF HHHHCCCHHHHHHHH	64.04	23201123
108	Phosphorylation	ELRQRAFTSQASATM HHHHHHHHCCCCEEE	20.95	19060867
109	Phosphorylation	LRQRAFTSQASATMH HHHHHHHCCCCEEEE	19.80	23984901
112	Phosphorylation	RAFTSQASATMHLPA HHHHCCCCEEEECCC	19.35	23984901
114	Phosphorylation	FTSQASATMHLPATI HHCCCCEEEECCCCC	11.57	23984901
128	Phosphorylation	IGDYTDFYSSRQHAT CCCCCHHHCCCCCCC	14.46	17242355
144	Ubiquitination	VGIMFRGKENALLPN EEEEECCCCCCCCCC	43.47	-
144	Malonylation	VGIMFRGKENALLPN EEEEECCCCCCCCCC	43.47	26073543
164	Phosphorylation	VGYHGRASSIVVSGT CCCCCCCCEEEEECC	21.16	29472430
165	Phosphorylation	GYHGRASSIVVSGTP CCCCCCCEEEEECCC	20.58	29472430
169	Phosphorylation	RASSIVVSGTPIRRP CCCEEEEECCCCCCC	26.51	29472430
186	Malonylation	QMRPDNSKPPVYGAC CCCCCCCCCCCCCHH	60.64	26320211
186	Ubiquitination	QMRPDNSKPPVYGAC CCCCCCCCCCCCCHH	60.64	-
219	Phosphorylation	FGEPIPISKAHEHIF CCCCEECHHHHHHHH	20.59	22324799
220	Acetylation	GEPIPISKAHEHIFG CCCEECHHHHHHHHE	55.25	23954790
244	Phosphorylation	RDIQQWEYVPLGPFL CCHHCCEEEECHHCC	12.38	17242355
254	Phosphorylation	LGPFLGKSFGTTISP CHHCCCCCCCCCCCC	27.40	23984901
257	Phosphorylation	FLGKSFGTTISPWVV CCCCCCCCCCCCCEE	20.95	23984901
258	Phosphorylation	LGKSFGTTISPWVVP CCCCCCCCCCCCEEE	21.60	23984901
260	Phosphorylation	KSFGTTISPWVVPMD CCCCCCCCCCEEEHH	15.60	23984901
278	Succinylation	PFVVPNPKQDPKPLP CEECCCCCCCCCCCC	74.17	23954790
278	Malonylation	PFVVPNPKQDPKPLP CEECCCCCCCCCCCC	74.17	26073543
282	Malonylation	PNPKQDPKPLPYLCH CCCCCCCCCCCCEEC	68.43	26073543
309	Phosphorylation	SLKGEGMSQAATICR EECCCCCCHHHHHHH	27.76	29472430
313	Phosphorylation	EGMSQAATICRSNFK CCCCHHHHHHHHHHH	24.51	25521595
315	S-nitrosylation	MSQAATICRSNFKHM CCHHHHHHHHHHHHH	3.20	22178444
315	S-palmitoylation	MSQAATICRSNFKHM CCHHHHHHHHHHHHH	3.20	28526873
315	S-nitrosocysteine	MSQAATICRSNFKHM CCHHHHHHHHHHHHH	3.20	-
317	Phosphorylation	QAATICRSNFKHMYW HHHHHHHHHHHHHHH	42.05	22324799
371	Acetylation	ELSWKGTKAIDVEQG EEEECCCEEEEECCC	52.60	23954790
371	Ubiquitination	ELSWKGTKAIDVEQG EEEECCCEEEEECCC	52.60	27667366
371	Malonylation	ELSWKGTKAIDVEQG EEEECCCEEEEECCC	52.60	26320211
380	Phosphorylation	IDVEQGQTRTFLLDG EEECCCCEEEEEECC	38.20	20469934
396	S-palmitoylation	EVIITGHCQGDGYRV EEEEEEECCCCCEEE	5.24	26165157
396	S-nitrosylation	EVIITGHCQGDGYRV EEEEEEECCCCCEEE	5.24	22178444
408	S-nitrosylation	YRVGFGQCAGKVLPA EEEECCCCCCEECCC	5.73	22178444
408	S-palmitoylation	YRVGFGQCAGKVLPA EEEECCCCCCEECCC	5.73	28526873
411	Acetylation	GFGQCAGKVLPALSP ECCCCCCEECCCCCC	23.29	22733758
417	Phosphorylation	GKVLPALSPA----- CEECCCCCCC-----	22.38	27180971

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAAA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAAA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAAA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FAAA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.